Detailed information of TA system TA022778

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-YefM
• Location: 4393549..4394006
• Replicon: chromosome
• Accession: NC_010546
• Organism: Cyanothece sp. ATCC 51142

Toxin (Protein)

• Gene name: relB
• Uniprot ID: B1WSN0
• Locus tag: CCE_RS20080
• Protein ID: WP_009543670.1
• Coordinates: 4393549..4393803 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1WSN1
• Locus tag: CCE_RS20085
• Protein ID: WP_009543669.1
• Coordinates: 4393800..4394006 (-)
• Length: 69 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCE_RS20060	4389031..4389444	-	414	WP_009543674.1	hypothetical protein	-
CCE_RS20065	4389480..4392203	-	2724	WP_009543673.1	valine--tRNA ligase	-
CCE_RS20070	4392394..4392855	+	462	WP_009543672.1	DUF29 domain-containing protein	-
CCE_RS20075	4392961..4393500	+	540	WP_009543671.1	hypothetical protein	-
CCE_RS20080	4393549..4393803	-	255	WP_009543670.1	Txe/YoeB family addiction module toxin	Toxin
CCE_RS20085	4393800..4394006	-	207	WP_009543669.1	prevent-host-death protein	Antitoxin
CCE_RS20090	4394045..4394302	-	258	WP_009543668.1	Txe/YoeB family addiction module toxin	-
CCE_RS20095	4394283..4394492	-	210	WP_009543667.1	prevent-host-death protein	-
CCE_RS20100	4394648..4395694	+	1047	WP_009543666.1	dipeptide epimerase	-
CCE_RS20105	4395738..4396538	+	801	WP_009543665.1	Mut7-C ubiquitin/RNAse domain-containing protein	-
CCE_RS20110	4396695..4397582	-	888	WP_009543664.1	phosphatidate cytidylyltransferase	-
CCE_RS20115	4397726..4398316	-	591	WP_009543663.1	precorrin-6Y C5,15-methyltransferase subunit CbiT	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10403.83 Da
• Isoelectric Point: 7.1621

>T22778 WP_009543670.1 NC_010546:c4393803-4393549 [Crocosphaera subtropica ATCC 51142]
MILKWSEQGWEDYLYWQQTDKKIIKRINKLIEDIKRDPFDGLGNPEPLKYNWSGFWSRRIDQEHRLVYAVENNEILIAQC
RYHY

Nucleotide

• Length: 255 bp

>T22778 NC_010546:c4393803-4393549 [Crocosphaera subtropica ATCC 51142]
ATGATTTTAAAATGGTCAGAACAAGGTTGGGAAGATTATTTATATTGGCAACAAACCGATAAAAAAATAATCAAACGTAT
CAATAAATTAATTGAAGACATTAAACGTGATCCTTTTGATGGACTGGGGAACCCTGAACCGTTAAAATATAATTGGTCTG
GGTTTTGGTCACGTCGTATTGATCAAGAACATCGTTTAGTTTATGCTGTAGAAAATAATGAAATTCTGATCGCTCAATGT
CGATATCATTATTGA

Antitoxin

Protein

• Length: 69 a.a.
• Molecular weight: 7828.79 Da
• Isoelectric Point: 4.1658

>AT22778 WP_009543669.1 NC_010546:c4394006-4393800 [Crocosphaera subtropica ATCC 51142]
MNLTDIQYVSNEQGQTVAVIVPIEIWREIESEKETAYLLKSPKNAERLNTAIQELRNGQGIERDLIEE

Nucleotide

• Length: 207 bp

>AT22778 NC_010546:c4394006-4393800 [Crocosphaera subtropica ATCC 51142]
ATGAACTTAACCGATATTCAGTATGTATCAAACGAACAAGGACAAACCGTTGCGGTTATTGTTCCTATTGAAATATGGCG
TGAGATAGAATCAGAAAAAGAAACCGCTTATTTATTAAAAAGTCCGAAAAATGCAGAAAGATTAAACACAGCAATACAAG
AACTAAGAAATGGACAAGGAATAGAAAGAGACTTAATTGAAGAATGA

Structures

Toxin

• AlphaFold DB: B1WSN0

Antitoxin

• AlphaFold DB: B1WSN1