Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 89112..89626 Replicon chromosome
Accession NZ_CP089162
Organism Staphylococcus aureus strain UNC_SaCF11

Toxin (Protein)


Gene name TsdT Uniprot ID T1YA99
Locus tag LTK16_RS00455 Protein ID WP_000581792.1
Coordinates 89417..89626 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID W8UW13
Locus tag LTK16_RS00450 Protein ID WP_000138932.1
Coordinates 89112..89405 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTK16_RS00430 (84375) 84375..85016 + 642 WP_000483153.1 thiamine phosphate synthase -
LTK16_RS00435 (85102) 85102..85974 + 873 WP_000725802.1 membrane protein insertase YidC -
LTK16_RS00440 (86787) 86787..87434 - 648 WP_001187629.1 HD domain-containing protein -
LTK16_RS00445 (87462) 87462..88946 - 1485 WP_000571549.1 cardiolipin synthase -
LTK16_RS00450 (89112) 89112..89405 + 294 WP_000138932.1 copper-sensing transcriptional repressor CsoR Antitoxin
LTK16_RS00455 (89417) 89417..89626 + 210 WP_000581792.1 heavy metal-associated domain-containing protein Toxin
LTK16_RS00460 (89754) 89754..89891 + 138 WP_000828354.1 Lmo0850 family protein -
LTK16_RS00465 (90155) 90155..91357 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
LTK16_RS00470 (91675) 91675..92745 + 1071 WP_000159631.1 D-alanine--D-alanine ligase -
LTK16_RS00475 (92760) 92760..94118 + 1359 WP_000611462.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7843.77 Da        Isoelectric Point: 4.1008

>T227775 WP_000581792.1 NZ_CP089162:89417-89626 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T227775 NZ_CP123036:2100975-2101078 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11197.82 Da        Isoelectric Point: 6.2243

>AT227775 WP_000138932.1 NZ_CP089162:89112-89405 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT227775 NZ_CP123036:c2101116-2100845 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6FF1

Antitoxin

Source ID Structure
AlphaFold DB W8UW13

References