Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 1600364..1600841 | Replicon | chromosome |
| Accession | NZ_CP089161 | ||
| Organism | Staphylococcus aureus strain UNC_SaCF13 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | T1Y7S2 |
| Locus tag | LTK21_RS07830 | Protein ID | WP_000052076.1 |
| Coordinates | 1600364..1600552 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | T1Y6P8 |
| Locus tag | LTK21_RS07835 | Protein ID | WP_001059690.1 |
| Coordinates | 1600581..1600841 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LTK21_RS07800 (LTK21_07800) | 1596358..1596879 | + | 522 | WP_000824482.1 | hypothetical protein | - |
| LTK21_RS07805 (LTK21_07805) | 1597220..1597906 | + | 687 | WP_000141557.1 | thermonuclease family protein | - |
| LTK21_RS07810 (LTK21_07810) | 1598263..1598463 | + | 201 | WP_001059082.1 | cold-shock protein | - |
| LTK21_RS07815 (LTK21_07815) | 1598955..1599173 | - | 219 | WP_000005886.1 | hypothetical protein | - |
| LTK21_RS07820 (LTK21_07820) | 1599235..1599519 | - | 285 | WP_001004399.1 | hypothetical protein | - |
| LTK21_RS07825 (LTK21_07825) | 1599607..1600176 | - | 570 | WP_001106654.1 | lipoprotein N-acylation protein LnsA | - |
| LTK21_RS07830 (LTK21_07830) | 1600364..1600552 | - | 189 | WP_000052076.1 | hypothetical protein | Toxin |
| LTK21_RS07835 (LTK21_07835) | 1600581..1600841 | - | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
| LTK21_RS07840 (LTK21_07840) | 1601182..1601385 | + | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
| LTK21_RS07845 (LTK21_07845) | 1601382..1601618 | - | 237 | WP_000349581.1 | hypothetical protein | - |
| LTK21_RS07850 (LTK21_07850) | 1601843..1602424 | + | 582 | WP_001140693.1 | histidine phosphatase family protein | - |
| LTK21_RS07855 (LTK21_07855) | 1602497..1603114 | - | 618 | WP_000255551.1 | LysE/ArgO family amino acid transporter | - |
| LTK21_RS07860 (LTK21_07860) | 1603269..1603763 | - | 495 | WP_000569884.1 | GNAT family N-acetyltransferase | - |
| LTK21_RS07865 (LTK21_07865) | 1604162..1604584 | - | 423 | WP_000974460.1 | organic hydroperoxide resistance protein | - |
| LTK21_RS07870 (LTK21_07870) | 1604732..1605448 | + | 717 | WP_000150011.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | tsst-1 / sec / sell / vWbp | 1566623..1601618 | 34995 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T227767 WP_000052076.1 NZ_CP089161:c1600552-1600364 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T227767 NZ_CP123036:769597-769893 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATACCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATACCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT227767 WP_001059690.1 NZ_CP089161:c1600841-1600581 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT227767 NZ_CP123036:769895-770290 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VP18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VN56 |