Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TscAT/- |
| Location | 1572687..1573216 | Replicon | chromosome |
| Accession | NZ_CP089161 | ||
| Organism | Staphylococcus aureus strain UNC_SaCF13 | ||
Toxin (Protein)
| Gene name | TscT | Uniprot ID | K7ZRX6 |
| Locus tag | LTK21_RS07675 | Protein ID | WP_001103939.1 |
| Coordinates | 1572899..1573216 (+) | Length | 106 a.a. |
Antitoxin (Protein)
| Gene name | TscA | Uniprot ID | X5IY59 |
| Locus tag | LTK21_RS07670 | Protein ID | WP_001058494.1 |
| Coordinates | 1572687..1572896 (+) | Length | 70 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LTK21_RS07635 (LTK21_07635) | 1569017..1569481 | + | 465 | WP_001085183.1 | SsrA-binding protein SmpB | - |
| LTK21_RS07645 (LTK21_07645) | 1570044..1571150 | - | 1107 | WP_000149511.1 | tyrosine-type recombinase/integrase | - |
| LTK21_RS07650 (LTK21_07650) | 1571140..1571943 | - | 804 | WP_000358990.1 | helix-turn-helix transcriptional regulator | - |
| LTK21_RS07655 (LTK21_07655) | 1572079..1572282 | + | 204 | WP_001045296.1 | transcriptional regulator | - |
| LTK21_RS07660 (LTK21_07660) | 1572318..1572536 | + | 219 | WP_000163544.1 | helix-turn-helix transcriptional regulator | - |
| LTK21_RS07665 (LTK21_07665) | 1572548..1572694 | + | 147 | WP_000784885.1 | hypothetical protein | - |
| LTK21_RS07670 (LTK21_07670) | 1572687..1572896 | + | 210 | WP_001058494.1 | hypothetical protein | Antitoxin |
| LTK21_RS07675 (LTK21_07675) | 1572899..1573216 | + | 318 | WP_001103939.1 | DUF1474 family protein | Toxin |
| LTK21_RS07680 (LTK21_07680) | 1573280..1574149 | + | 870 | WP_001002717.1 | primase alpha helix C-terminal domain-containing protein | - |
| LTK21_RS07685 (LTK21_07685) | 1574166..1575623 | + | 1458 | WP_000390453.1 | virulence-associated E family protein | - |
| LTK21_RS07690 (LTK21_07690) | 1575924..1576286 | + | 363 | WP_001039170.1 | hypothetical protein | - |
| LTK21_RS07695 (LTK21_07695) | 1576288..1576572 | + | 285 | WP_000998185.1 | hypothetical protein | - |
| LTK21_RS07700 (LTK21_07700) | 1576569..1577210 | + | 642 | WP_001019808.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | tsst-1 / sec / sell / vWbp | 1566623..1601618 | 34995 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 106 a.a. Molecular weight: 12547.17 Da Isoelectric Point: 5.0161
>T227766 WP_001103939.1 NZ_CP089161:1572899-1573216 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFGELIQKF
HEIEKASSENFGEVSDDAQKLKITE
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLHVYLKEFGELIQKF
HEIEKASSENFGEVSDDAQKLKITE
Download Length: 318 bp
>T227766 NZ_CP123036:c656635-656171 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGATGCTTTAGTTGC
CGAAGTCGAGGCATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCTGCCACAAAGTTATTGGCGGTGGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGCTATCGTCTCTTCTTTCGTTACAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACGCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGTAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAAGCCTCACCCAAGAGACAGAAGAAAACCATTGA
Antitoxin
Download Length: 70 a.a. Molecular weight: 8268.31 Da Isoelectric Point: 4.3718
>AT227766 WP_001058494.1 NZ_CP089161:1572687-1572896 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNSIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNSIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE
Download Length: 210 bp
>AT227766 NZ_CP123036:c656970-656635 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTCTTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|