Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TscAT/- |
| Location | 1123014..1123552 | Replicon | chromosome |
| Accession | NZ_CP089161 | ||
| Organism | Staphylococcus aureus strain UNC_SaCF13 | ||
Toxin (Protein)
| Gene name | TscT | Uniprot ID | - |
| Locus tag | LTK21_RS05415 | Protein ID | WP_000383747.1 |
| Coordinates | 1123226..1123552 (+) | Length | 109 a.a. |
Antitoxin (Protein)
| Gene name | TscA | Uniprot ID | A0A0H3JSN0 |
| Locus tag | LTK21_RS05410 | Protein ID | WP_001058495.1 |
| Coordinates | 1123014..1123223 (+) | Length | 70 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LTK21_RS05370 (LTK21_05370) | 1118045..1118548 | + | 504 | WP_000934799.1 | single-stranded DNA-binding protein | - |
| LTK21_RS05375 (LTK21_05375) | 1118600..1118842 | + | 243 | WP_000897044.1 | 30S ribosomal protein S18 | - |
| LTK21_RS05380 (LTK21_05380) | 1119081..1119980 | - | 900 | WP_001797289.1 | Abi family protein | - |
| LTK21_RS05385 (LTK21_05385) | 1119982..1121196 | - | 1215 | WP_191682956.1 | site-specific integrase | - |
| LTK21_RS05390 (LTK21_05390) | 1121495..1122229 | - | 735 | WP_000142630.1 | helix-turn-helix transcriptional regulator | - |
| LTK21_RS05395 (LTK21_05395) | 1122378..1122590 | + | 213 | WP_001063624.1 | helix-turn-helix transcriptional regulator | - |
| LTK21_RS05400 (LTK21_05400) | 1122591..1122863 | + | 273 | WP_001138298.1 | helix-turn-helix domain-containing protein | - |
| LTK21_RS05405 (LTK21_05405) | 1122875..1123021 | + | 147 | WP_000784887.1 | hypothetical protein | - |
| LTK21_RS05410 (LTK21_05410) | 1123014..1123223 | + | 210 | WP_001058495.1 | hypothetical protein | Antitoxin |
| LTK21_RS05415 (LTK21_05415) | 1123226..1123552 | + | 327 | WP_000383747.1 | DUF1474 family protein | Toxin |
| LTK21_RS05420 (LTK21_05420) | 1123617..1124486 | + | 870 | WP_191682955.1 | primase alpha helix C-terminal domain-containing protein | - |
| LTK21_RS05425 (LTK21_05425) | 1124500..1126209 | + | 1710 | WP_191682954.1 | DUF927 domain-containing protein | - |
| LTK21_RS05430 (LTK21_05430) | 1126519..1126899 | + | 381 | WP_000356942.1 | hypothetical protein | - |
| LTK21_RS05435 (LTK21_05435) | 1126896..1127537 | + | 642 | WP_191682953.1 | pathogenicity island protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 1118045..1138933 | 20888 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 109 a.a. Molecular weight: 12985.33 Da Isoelectric Point: 4.3050
>T227765 WP_000383747.1 NZ_CP089161:1123226-1123552 [Staphylococcus aureus]
MDWEIKSLFSDLKLLKDSFEDLKDSKGWHFDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSENFGEESDDAKNSIKVAE
MDWEIKSLFSDLKLLKDSFEDLKDSKGWHFDELYPYEPNHVLNKDELIGEGFSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFYEIEKASSENFGEESDDAKNSIKVAE
Download Length: 327 bp
>T227765 NZ_CP123036:340532-341059 [Escherichia coli]
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA
ATGGATGATCTGACGATAGAGATTCTGACCGATGATGCAGATTATGATCTACAGCGATTCGACTGCGGCGAGGAAGCGTT
AAATCTCTTTCTGACGACACATCTCGTTCGTCAACATCGCAACAAAATTCTGCGAGCGTATATCCTTTGTCGCAACACTC
CAGAACGTCAGGTGCTGGGATATTACACATTATGCGGCAGTTGTTTTGAACGAGCCGCATTGCCCTCGAAATCGAAACAG
AAAAAAATTCCCTACAAAAATATTCCCAGCGTTACTCTTGGGCGTCTGGCAATTGATCGTTCATTACAGGGGCAGGGATG
GGGAGCAACACTGGTTGCTCATGCCATGAAAGTCGTCTGGTCAGCCTCTTTAGCGGTAGGTATTCACGGTCTTTTTGTCG
AGGCGCTGAATAAAAAAGCCCATACGTTTTATCAATCGCTGGGCTTTATCCCGTTGGTCGGAGAAAACGAAAATGCGTTA
TTTTTCCCAACCAAATCCATCGAACTGCTTTTCACACAGAGCGATTAA
Antitoxin
Download Length: 70 a.a. Molecular weight: 8206.22 Da Isoelectric Point: 4.3718
>AT227765 WP_001058495.1 NZ_CP089161:1123014-1123223 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVVNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE
MNNEQKEVIEHVVYQLELSVVNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE
Download Length: 210 bp
>AT227765 NZ_CP123036:340259-340525 [Escherichia coli]
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCTGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA
ATGTCTGCTGTTAAAAAGCAGCGTATCGATCTGCGTTTAACTGACGATGACAAAAGTATGATTGAGGAAGCGGCAGCGAT
ATCTAATCAGTCCGTCAGCCAATTTATGTTGAACAGCGCTTCGCAGCGGGCTGCGGAAGTGATTGAACAGCATCGGCGGG
TGATCCTCAATGAGGAATCCTGGACGCGGGTGATGGATGCGCTGAGTAATCCACCGTCACCTGGTGAAAAGCTAAAACGT
GCGGCAAAACGTCTTCAGGGAATGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|