227764

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 406799..407322 Replicon chromosome
Accession NZ_CP089161
Organism Staphylococcus aureus strain UNC_SaCF13

Toxin (Protein)


Gene name relE Uniprot ID A0A3A5LQI3
Locus tag LTK21_RS02090 Protein ID WP_000074049.1
Coordinates 406799..407065 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID W8TQT5
Locus tag LTK21_RS02095 Protein ID WP_000587616.1
Coordinates 407065..407322 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTK21_RS02070 (LTK21_02070) 402106..403293 - 1188 WP_000026189.1 MFS transporter -
LTK21_RS02075 (LTK21_02075) 403689..404465 - 777 WP_000072149.1 iron export ABC transporter permease subunit FetB -
LTK21_RS02080 (LTK21_02080) 404458..405120 - 663 WP_000923526.1 ATP-binding cassette domain-containing protein -
LTK21_RS02085 (LTK21_02085) 405368..406444 - 1077 WP_001076673.1 M42 family metallopeptidase -
LTK21_RS02090 (LTK21_02090) 406799..407065 - 267 WP_000074049.1 Txe/YoeB family addiction module toxin Toxin
LTK21_RS02095 (LTK21_02095) 407065..407322 - 258 WP_000587616.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LTK21_RS02100 (LTK21_02100) 407681..408136 + 456 WP_000732076.1 DUF1307 domain-containing protein -
LTK21_RS02105 (LTK21_02105) 408304..409881 - 1578 WP_000143494.1 FMN-binding glutamate synthase family protein -
LTK21_RS02110 (LTK21_02110) 410076..410822 + 747 WP_214308004.1 CPBP family lipoprotein N-acylation protein LnsB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(4-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-68)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10676.24 Da        Isoelectric Point: 10.1597

>T227764 WP_000074049.1 NZ_CP089161:c407065-406799 [Staphylococcus aureus]
MSNYTVKIKNSAKSDLRKIKHSYLKKSFLEIVETLKNDPYKITQSFEKLEPKYLERYSRRINHQHRVVYTVDDRNKEVLI
LSAWSHYD

Download         Length: 267 bp

>T227764 NZ_CP123036:318968-319198 [Escherichia coli]
CTGGATCAGCTATTTAAATCACCTTTACCTCAAGGAATCAAATGGACTGATATAGAATCTCTGGTTAAAGCGTTAGGCGG
AGAAATTAAGGAAGGTAGGGGGTCGCGCTGTAAGTTCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGT
CGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTGCGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9774.73 Da        Isoelectric Point: 4.1353

>AT227764 WP_000587616.1 NZ_CP089161:c407322-407065 [Staphylococcus aureus]
MIITSPTEARKDFYQLLKNVNNNHEPIYISGNNAENNAVIIGLEDWKSIQETIYLESTGTMDKVREREKDNSGTTNIDDI
DWDNL

Download         Length: 258 bp

>AT227764 NZ_CP123036:319195-319554 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AACTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACGTTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3A5LQI3

Antitoxin

Source ID Structure
AlphaFold DB W8TQT5

References