Detailed information of TA system TA022776

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 583877..584509
• Replicon: chromosome
• Accession: NC_010546
• Organism: Cyanothece sp. ATCC 51142

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CCE_RS02790
• Protein ID: WP_009546661.1
• Coordinates: 584114..584509 (+)
• Length: 132 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A1KYF6
• Locus tag: CCE_RS02785
• Protein ID: WP_009546660.1
• Coordinates: 583877..584113 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCE_RS02765	580287..580541	+	255	WP_009546656.1	ferrous iron transport protein A	-
CCE_RS02770	580665..581477	+	813	WP_009546657.1	sulfite exporter TauE/SafE family protein	-
CCE_RS02775	581507..583462	+	1956	WP_009546658.1	molybdate ABC transporter permease subunit	-
CCE_RS02780	583482..583778	+	297	WP_009546659.1	ferredoxin III, nif-specific	-
CCE_RS02785	583877..584113	+	237	WP_009546660.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
CCE_RS02790	584114..584509	+	396	WP_009546661.1	type II toxin-antitoxin system VapC family toxin	Toxin
CCE_RS02795	584633..584869	+	237	WP_009546662.1	hypothetical protein	-
CCE_RS02800	584871..585257	+	387	WP_009546663.1	type II toxin-antitoxin system VapC family toxin	-
CCE_RS02805	585406..585882	+	477	WP_009546664.1	hypothetical protein	-
CCE_RS25190	585925..586167	+	243	WP_198019424.1	DUF433 domain-containing protein	-
CCE_RS02810	586330..586581	+	252	WP_009546665.1	hypothetical protein	-
CCE_RS02815	586645..587304	+	660	WP_009546666.1	ComF family protein	-
CCE_RS02820	587396..588235	+	840	WP_009546667.1	tetratricopeptide repeat protein	-
CCE_RS02825	588326..588661	-	336	WP_009546668.1	c-type cytochrome	-
CCE_RS02830	588900..589259	+	360	WP_009546669.1	plastocyanin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Antitoxin

• SpoVT-AbrB domain (9-46)

Sequences

Toxin

Protein

• Length: 132 a.a.
• Molecular weight: 15422.86 Da
• Isoelectric Point: 7.8018

>T22776 WP_009546661.1 NC_010546:584114-584509 [Crocosphaera subtropica ATCC 51142]
MYMLDTNICIYIIKKRPSTVLTRFQTISSENLYISVMTVAELQYGVDKSNAKRKNQEILDDFISRLQVLPWEETAVQYYS
KIRNYLEAKGTFIGNMDMLIAAHCQSKNYILVTNNIREFERIPDLKVENWI

Nucleotide

• Length: 396 bp

>T22776 NC_010546:584114-584509 [Crocosphaera subtropica ATCC 51142]
ATGTATATGTTAGATACGAATATTTGTATCTATATCATTAAAAAGCGTCCATCTACAGTATTAACTCGTTTTCAAACTAT
TTCATCTGAAAACTTGTATATTTCTGTGATGACTGTAGCTGAATTACAATACGGTGTAGATAAATCGAATGCTAAAAGGA
AGAATCAAGAGATTTTAGATGATTTTATCTCACGCTTACAAGTTTTACCTTGGGAAGAAACAGCAGTACAATACTATAGC
AAAATTCGTAATTATTTAGAAGCAAAAGGGACTTTTATTGGTAATATGGATATGTTGATTGCAGCACATTGTCAAAGTAA
AAACTATATCTTAGTTACTAATAATATTCGAGAATTTGAAAGAATTCCTGATCTAAAAGTAGAAAACTGGATTTAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 9347.74 Da
• Isoelectric Point: 8.6188

>AT22776 WP_009546660.1 NC_010546:583877-584113 [Crocosphaera subtropica ATCC 51142]
MKQKTAKLFMNGRSQAVRLPQEFRFEGKEVYIHRVGNKVILSPKPTTWEDFFEKTPLPSEDFMEQRIDFPPQTREELF

Nucleotide

• Length: 237 bp

>AT22776 NC_010546:583877-584113 [Crocosphaera subtropica ATCC 51142]
ATGAAACAAAAAACAGCTAAACTCTTTATGAATGGCCGTAGTCAAGCTGTGCGGTTGCCTCAAGAATTTCGATTTGAAGG
GAAAGAAGTTTATATTCATAGAGTAGGAAATAAAGTGATCTTATCTCCTAAACCGACTACCTGGGAAGACTTTTTTGAGA
AAACCCCTTTACCCTCAGAAGATTTTATGGAACAAAGAATTGATTTCCCTCCTCAAACTAGAGAGGAACTATTCTAA

Structures

Antitoxin

• AlphaFold DB: A1KYF6