227759

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 11833..12362 Replicon chromosome
Accession NZ_CP089161
Organism Staphylococcus aureus strain UNC_SaCF13

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag LTK21_RS00055 Protein ID WP_000621175.1
Coordinates 11833..12195 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID T1YCG8
Locus tag LTK21_RS00060 Protein ID WP_000948331.1
Coordinates 12192..12362 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTK21_RS00035 (LTK21_00035) 8811..9581 - 771 WP_001041111.1 RNA polymerase sigma factor SigB -
LTK21_RS00040 (LTK21_00040) 9556..10035 - 480 WP_001190829.1 anti-sigma B factor RsbW -
LTK21_RS00045 (LTK21_00045) 10037..10363 - 327 WP_001052491.1 anti-sigma factor antagonist -
LTK21_RS00050 (LTK21_00050) 10482..11483 - 1002 WP_000390829.1 PP2C family protein-serine/threonine phosphatase -
LTK21_RS00055 (LTK21_00055) 11833..12195 - 363 WP_000621175.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
LTK21_RS00060 (LTK21_00060) 12192..12362 - 171 WP_000948331.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
LTK21_RS00065 (LTK21_00065) 12447..13595 - 1149 WP_001281154.1 alanine racemase -
LTK21_RS00070 (LTK21_00070) 13661..14020 - 360 WP_000581197.1 holo-ACP synthase -
LTK21_RS00075 (LTK21_00075) 14024..14515 - 492 WP_001205912.1 PH domain-containing protein -
LTK21_RS00080 (LTK21_00080) 14502..16085 - 1584 WP_191682995.1 PH domain-containing protein -
LTK21_RS00085 (LTK21_00085) 16078..16557 - 480 WP_001287087.1 hypothetical protein -
LTK21_RS00090 (LTK21_00090) 16765..17325 - 561 WP_001092411.1 K(+)-transporting ATPase subunit C -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-110)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13441.69 Da        Isoelectric Point: 10.1654

>T227759 WP_000621175.1 NZ_CP089161:c12195-11833 [Staphylococcus aureus]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Download         Length: 363 bp

>T227759 NZ_CP123031:c44467-44333 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6251.78 Da        Isoelectric Point: 3.8305

>AT227759 WP_000948331.1 NZ_CP089161:c12362-12192 [Staphylococcus aureus]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Download         Length: 171 bp

>AT227759 NZ_CP123031:44512-44572 [Escherichia coli]
TAAAGTGCATCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VRZ1

References