Detailed information of TA system TA022775

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YoeB-YefM
• Location: 39939..40527
• Replicon: chromosome
• Accession: NC_010546
• Organism: Cyanothece sp. ATCC 51142

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B1WYH2
• Locus tag: CCE_RS00245
• Protein ID: WP_009543148.1
• Coordinates: 40216..40527 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1WYH1
• Locus tag: CCE_RS00240
• Protein ID: WP_009543149.1
• Coordinates: 39939..40235 (+)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCE_RS00210	35752..36318	-	567	WP_009543155.1	HAD family hydrolase	-
CCE_RS00215	36330..36920	-	591	WP_009543154.1	D-sedoheptulose 7-phosphate isomerase	-
CCE_RS00220	36942..37868	-	927	WP_009543153.1	NAD-dependent epimerase/dehydratase family protein	-
CCE_RS25690	38731..38732	-	2	WP_156922830.1	IS630 family transposase	-
CCE_RS25090	39503..39580	+	78	WP_012361266.1	pentapeptide repeat-containing protein	-
CCE_RS00235	39608..39841	+	234	WP_009543150.1	hypothetical protein	-
CCE_RS00240	39939..40235	+	297	WP_009543149.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
CCE_RS00245	40216..40527	+	312	WP_009543148.1	Txe/YoeB family addiction module toxin	Toxin
CCE_RS25095	40552..41226	+	675	Protein_48	Uma2 family endonuclease	-
CCE_RS00255	41733..42119	+	387	WP_009543146.1	DUF1499 domain-containing protein	-
CCE_RS00260	42170..43123	+	954	WP_009543145.1	alpha/beta hydrolase	-
CCE_RS00270	43329..44159	+	831	WP_009543144.1	prolipoprotein diacylglyceryl transferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (23-102)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (6-73)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12473.51 Da
• Isoelectric Point: 10.4442

>T22775 WP_009543148.1 NC_010546:40216-40527 [Crocosphaera subtropica ATCC 51142]
MNKKKNKQKNEKKSPIVKQIPGFSQQFKEDLKWWFKTDPKKASRILDLVTEVMKDPFQGIGKPEPLKYMDSNIWSRRIDL
EHRLIYRVSQTQLDFLSCRFHYE

Nucleotide

• Length: 312 bp

>T22775 NC_010546:40216-40527 [Crocosphaera subtropica ATCC 51142]
TTGAACAAGAAGAAGAATAAGCAAAAAAATGAAAAAAAATCACCTATTGTTAAACAAATTCCTGGTTTTAGTCAGCAATT
TAAAGAAGATTTAAAATGGTGGTTCAAAACTGATCCTAAAAAAGCTTCAAGGATTTTAGATTTAGTGACAGAAGTTATGA
AAGATCCATTTCAAGGAATAGGAAAACCAGAACCTTTAAAATATATGGATAGCAATATTTGGTCAAGACGCATTGATTTA
GAACATCGTTTAATTTATCGAGTTAGTCAAACTCAACTTGATTTTCTTTCTTGTCGTTTTCATTATGAGTAA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 11206.56 Da
• Isoelectric Point: 4.2057

>AT22775 WP_009543149.1 NC_010546:39939-40235 [Crocosphaera subtropica ATCC 51142]
MFSYEITSPTEARNSLFQLLEKVAKDHQVCIINRNDGENVALISESDLRSLVETVYLLRNPANARRLFDAIDESITGKIQ
PQTLEELKQELGIEQEEE

Nucleotide

• Length: 297 bp

>AT22775 NC_010546:39939-40235 [Crocosphaera subtropica ATCC 51142]
ATGTTTAGTTATGAAATAACATCACCCACTGAAGCAAGAAATAGTTTATTTCAGTTATTGGAAAAAGTGGCAAAAGATCA
TCAGGTATGTATCATCAATCGTAATGATGGAGAAAATGTCGCTTTAATTTCTGAATCTGACTTAAGAAGTTTAGTAGAAA
CAGTTTATTTATTGCGAAACCCTGCCAATGCACGTCGATTATTTGATGCCATAGACGAATCTATCACGGGAAAAATACAA
CCTCAAACTCTTGAAGAATTAAAACAGGAATTAGGAATTGAACAAGAAGAAGAATAA

Structures

Toxin

• AlphaFold DB: B1WYH2

Antitoxin

• AlphaFold DB: B1WYH1