Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 4851406..4852076 Replicon chromosome
Accession NC_010524
Organism Leptothrix cholodnii SP-6

Toxin (Protein)


Gene name vapC Uniprot ID B1Y0A6
Locus tag LCHO_RS21570 Protein ID WP_012349326.1
Coordinates 4851406..4851825 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B1Y0A7
Locus tag LCHO_RS21575 Protein ID WP_012349327.1
Coordinates 4851822..4852076 (-) Length 85 a.a.

Genomic Context

LCHO_RS21560LCHO_RS21565LCHO_RS21580LCHO_RS21585LCHO_RS21555LCHO_RS21570LCHO_RS21575LCHO_RS21590LCHO_RS21595
Location: 4848598..4849770 (1173 bp)
Type: Others
Protein ID: WP_043706142.1
Location: 4849893..4851338 (1446 bp)
Type: Others
Protein ID: WP_012349325.1
Location: 4852240..4852899 (660 bp)
Type: Others
Protein ID: WP_012349328.1
Location: 4852915..4853565 (651 bp)
Type: Others
Protein ID: WP_012349329.1
Location: 4846854..4848425 (1572 bp)
Type: Others
Protein ID: WP_043704577.1
Location: 4851406..4851825 (420 bp)
Type: Toxin
Protein ID: WP_012349326.1
Location: 4851822..4852076 (255 bp)
Type: Antitoxin
Protein ID: WP_012349327.1
Location: 4853580..4854950 (1371 bp)
Type: Others
Protein ID: WP_012349330.1
Location: 4854954..4856756 (1803 bp)
Type: Others
Protein ID: WP_012349331.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LCHO_RS215554846854..4848425-1572WP_043704577.1cache domain-containing protein-
LCHO_RS215604848598..4849770+1173WP_043706142.1MFS transporter-
LCHO_RS215654849893..4851338+1446WP_012349325.1RES family NAD+ phosphorylase-
LCHO_RS215704851406..4851825-420WP_012349326.1type II toxin-antitoxin system VapC family toxinToxin
LCHO_RS215754851822..4852076-255WP_012349327.1Arc family DNA-binding proteinAntitoxin
LCHO_RS215804852240..4852899+660WP_012349328.1LysE family transporter-
LCHO_RS215854852915..4853565+651WP_012349329.1FMN-binding negative transcriptional regulator-
LCHO_RS215904853580..4854950-1371WP_012349330.1sigma-54 dependent transcriptional regulator-
LCHO_RS215954854954..4856756-1803WP_012349331.1sensor histidine kinase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 14668.14 Da        Isoelectric Point: 7.9697

>T22774 WP_012349326.1 NC_010524:c4851825-4851406 [Leptothrix cholodnii SP-6]
MILLDTNVVSEPLRRAPDARVIAWIDAQPLETLYLSAITVAELRAGVALLPAGKRRTGLLDNLEKRVLPLFAGRVLPFDV
ACTQAYAVLMAKARAAGLAIATADGYIAAIAAANRFAVATRDTGPFEAAGADVINPWLA

Download         Length: 420 bp

>T22774 NC_010524:c4851825-4851406 [Leptothrix cholodnii SP-6]
ATGATCCTGCTCGACACCAACGTGGTGTCGGAGCCCCTGCGCCGCGCACCCGACGCCCGCGTGATCGCGTGGATCGACGC
CCAGCCGCTCGAAACGCTGTACCTGTCCGCCATCACCGTGGCCGAGCTGCGCGCGGGCGTGGCACTGCTGCCCGCTGGCA
AGCGCCGCACAGGTTTGCTGGACAACCTGGAGAAACGGGTGCTGCCGCTGTTTGCTGGCCGCGTGCTGCCCTTTGACGTG
GCTTGCACCCAGGCCTATGCGGTCTTGATGGCCAAGGCGCGGGCCGCAGGGCTTGCCATTGCGACTGCCGATGGCTACAT
CGCGGCTATCGCCGCTGCCAACCGCTTTGCGGTGGCCACCCGCGACACCGGCCCCTTCGAGGCGGCTGGTGCGGATGTGA
TCAATCCGTGGCTGGCGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9371.66 Da        Isoelectric Point: 6.7270

>AT22774 WP_012349327.1 NC_010524:c4852076-4851822 [Leptothrix cholodnii SP-6]
MAMLTVRNLPDEVHRALRVRAAQHGHSMESEVREILESAVSPQGRVKLGTLLADMGRQARLSDEEFAVFEQARDKAAARP
VSFE

Download         Length: 255 bp

>AT22774 NC_010524:c4852076-4851822 [Leptothrix cholodnii SP-6]
ATGGCCATGCTGACAGTTCGCAACCTGCCCGACGAAGTGCATCGCGCCCTGCGTGTGCGTGCCGCCCAGCACGGTCACAG
CATGGAATCCGAGGTGCGCGAGATCCTGGAGTCCGCGGTCAGCCCGCAAGGTCGGGTCAAGCTGGGCACGCTGCTGGCCG
ACATGGGCCGGCAGGCCAGACTGAGCGATGAAGAGTTTGCCGTCTTCGAGCAGGCGCGCGACAAGGCCGCCGCCCGCCCG
GTGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBB1Y0A6

Antitoxin

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Source
ID
Structure
AlphaFold DBB1Y0A7

References