Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | TsaAT/- |
| Location | 2256186..2256663 | Replicon | chromosome |
| Accession | NZ_CP089157 | ||
| Organism | Staphylococcus aureus strain UNC_SaCF30 | ||
Toxin (Protein)
| Gene name | TsaT | Uniprot ID | T1Y7S2 |
| Locus tag | LTK17_RS10970 | Protein ID | WP_000052076.1 |
| Coordinates | 2256186..2256374 (-) | Length | 63 a.a. |
Antitoxin (Protein)
| Gene name | TsaA | Uniprot ID | T1Y6P8 |
| Locus tag | LTK17_RS10975 | Protein ID | WP_001059690.1 |
| Coordinates | 2256403..2256663 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LTK17_RS10940 (LTK17_10940) | 2252139..2252696 | + | 558 | WP_000824491.1 | hypothetical protein | - |
| LTK17_RS10945 (LTK17_10945) | 2253037..2253723 | + | 687 | WP_001574556.1 | thermonuclease family protein | - |
| LTK17_RS10950 (LTK17_10950) | 2254080..2254280 | + | 201 | WP_001059082.1 | cold-shock protein | - |
| LTK17_RS10955 (LTK17_10955) | 2254777..2254995 | - | 219 | WP_000005879.1 | hypothetical protein | - |
| LTK17_RS10960 (LTK17_10960) | 2255057..2255341 | - | 285 | WP_001004401.1 | hypothetical protein | - |
| LTK17_RS10965 (LTK17_10965) | 2255429..2255998 | - | 570 | WP_001106663.1 | lipoprotein N-acylation protein LnsA | - |
| LTK17_RS10970 (LTK17_10970) | 2256186..2256374 | - | 189 | WP_000052076.1 | hypothetical protein | Toxin |
| LTK17_RS10975 (LTK17_10975) | 2256403..2256663 | - | 261 | WP_001059690.1 | hypothetical protein | Antitoxin |
| LTK17_RS10980 (LTK17_10980) | 2257004..2257207 | + | 204 | WP_000145163.1 | sterile alpha motif-like domain-containing protein | - |
| LTK17_RS10985 (LTK17_10985) | 2257204..2257440 | - | 237 | WP_000368687.1 | hypothetical protein | - |
| LTK17_RS10990 (LTK17_10990) | 2257665..2258246 | + | 582 | WP_001140696.1 | histidine phosphatase family protein | - |
| LTK17_RS10995 (LTK17_10995) | 2258319..2258936 | - | 618 | WP_000255545.1 | LysE/ArgO family amino acid transporter | - |
| LTK17_RS11000 (LTK17_11000) | 2259092..2259586 | - | 495 | WP_000569884.1 | GNAT family N-acetyltransferase | - |
| LTK17_RS11005 (LTK17_11005) | 2259985..2260407 | - | 423 | WP_000974455.1 | organic hydroperoxide resistance protein | - |
| LTK17_RS11010 (LTK17_11010) | 2260555..2261271 | + | 717 | WP_000150036.1 | type I 3-dehydroquinate dehydratase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | ant(9)-Ia / erm(A) / blaZ | vWbp / vWbp | 2225350..2367744 | 142394 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 63 a.a. Molecular weight: 7142.82 Da Isoelectric Point: 9.9971
>T227738 WP_000052076.1 NZ_CP089157:c2256374-2256186 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL
Download Length: 189 bp
>T227738 NZ_CP123025:98519-98899 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTAGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGCAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTAGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG
Antitoxin
Download Length: 87 a.a. Molecular weight: 9940.09 Da Isoelectric Point: 4.0624
>AT227738 WP_001059690.1 NZ_CP089157:c2256663-2256403 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG
Download Length: 261 bp
>AT227738 NZ_CP123025:98298-98519 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VP18 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0VN56 |