227733

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 797061..797575 Replicon chromosome
Accession NZ_CP089157
Organism Staphylococcus aureus strain UNC_SaCF30

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag LTK17_RS03960 Protein ID WP_000581791.1
Coordinates 797061..797270 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag LTK17_RS03965 Protein ID WP_000138934.1
Coordinates 797282..797575 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTK17_RS03940 (LTK17_03940) 792950..794020 - 1071 WP_000159639.1 D-alanine--D-alanine ligase -
LTK17_RS03945 (LTK17_03945) 794338..795540 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
LTK17_RS03950 (LTK17_03950) 795701..796384 - 684 Protein_744 transposase -
LTK17_RS03955 (LTK17_03955) 796796..796933 - 138 WP_000828354.1 Lmo0850 family protein -
LTK17_RS03960 (LTK17_03960) 797061..797270 - 210 WP_000581791.1 heavy metal-associated domain-containing protein Toxin
LTK17_RS03965 (LTK17_03965) 797282..797575 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
LTK17_RS03970 (LTK17_03970) 797741..799225 + 1485 WP_000571560.1 cardiolipin synthase -
LTK17_RS03975 (LTK17_03975) 799253..799900 + 648 WP_001187612.1 HD domain-containing protein -
LTK17_RS03980 (LTK17_03980) 800057..800356 + 300 WP_001793952.1 hypothetical protein -
LTK17_RS03985 (LTK17_03985) 800513..801385 - 873 WP_000725802.1 membrane protein insertase YidC -
LTK17_RS03990 (LTK17_03990) 801471..802112 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T227733 WP_000581791.1 NZ_CP089157:c797270-797061 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T227733 NZ_CP123024:3595647-3595865 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTTTGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT227733 WP_000138934.1 NZ_CP089157:c797575-797282 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT227733 NZ_CP123024:3595247-3595621 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References