Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3253395..3254052 Replicon chromosome
Accession NC_010524
Organism Leptothrix cholodnii SP-6

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LCHO_RS14765 Protein ID WP_012347970.1
Coordinates 3253395..3253805 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B1XYH2
Locus tag LCHO_RS14770 Protein ID WP_012347971.1
Coordinates 3253819..3254052 (-) Length 78 a.a.

Genomic Context

LCHO_RS14745LCHO_RS14755LCHO_RS14760LCHO_RS14775LCHO_RS14785LCHO_RS14790LCHO_RS14750LCHO_RS14765LCHO_RS14770LCHO_RS23425LCHO_RS22820LCHO_RS14780
Location: 3249435..3249737 (303 bp)
Type: Others
Protein ID: WP_012347965.1
Location: 3251121..3252008 (888 bp)
Type: Others
Protein ID: WP_012347968.1
Location: 3252040..3253377 (1338 bp)
Type: Others
Protein ID: WP_012347969.1
Location: 3254045..3254323 (279 bp)
Type: Others
Protein ID: WP_043704348.1
Location: 3257259..3257849 (591 bp)
Type: Others
Protein ID: WP_012347975.1
Location: 3257925..3258560 (636 bp)
Type: Others
Protein ID: WP_012347976.1
Location: 3249754..3250878 (1125 bp)
Type: Others
Protein ID: WP_012347966.1
Location: 3253395..3253805 (411 bp)
Type: Toxin
Protein ID: WP_012347970.1
Location: 3253819..3254052 (234 bp)
Type: Antitoxin
Protein ID: WP_012347971.1
Location: 3254528..3255202 (675 bp)
Type: Others
Protein ID: WP_012347972.1
Location: 3255202..3256251 (1050 bp)
Type: Others
Protein ID: WP_012347973.1
Location: 3256555..3257034 (480 bp)
Type: Others
Protein ID: WP_012347974.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LCHO_RS147453249435..3249737+303WP_012347965.1N-acetyltransferase-
LCHO_RS147503249754..3250878-1125WP_012347966.1trypsin-like peptidase domain-containing protein-
LCHO_RS147553251121..3252008+888WP_012347968.1EamA family transporter RarD-
LCHO_RS147603252040..3253377+1338WP_012347969.1ABC transporter substrate-binding protein-
LCHO_RS147653253395..3253805-411WP_012347970.1type II toxin-antitoxin system VapC family toxinToxin
LCHO_RS147703253819..3254052-234WP_012347971.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
LCHO_RS147753254045..3254323+279WP_043704348.1hypothetical protein-
LCHO_RS234253254528..3255202-675WP_012347972.1hypothetical protein-
LCHO_RS228203255202..3256251-1050WP_012347973.1DUF262 domain-containing protein-
LCHO_RS147803256555..3257034-480WP_012347974.1VOC family protein-
LCHO_RS147853257259..3257849+591WP_012347975.1CBS domain-containing protein-
LCHO_RS147903257925..3258560+636WP_012347976.1glutathione S-transferase family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 14847.14 Da        Isoelectric Point: 6.8809

>T22773 WP_012347970.1 NC_010524:c3253805-3253395 [Leptothrix cholodnii SP-6]
MLKYLLDTNIVIYVIKRRPIEVMGVFNENAGRMAISAITLSELYHGAEKSAKVAQNLAVVEEFSSLLEVLPYTAKAASHY
GAIRTALEKAGQPIGLNDLHIAAHARSEGLTLVTNNLGEFERVPGLLVENWVGSRT

Download         Length: 411 bp

>T22773 NC_010524:c3253805-3253395 [Leptothrix cholodnii SP-6]
ATGCTCAAGTACCTGCTCGATACCAACATCGTCATCTACGTCATCAAGCGTCGGCCGATCGAGGTGATGGGTGTCTTCAA
CGAAAACGCCGGCCGCATGGCCATCTCGGCCATCACCCTGAGCGAGCTCTACCACGGGGCCGAGAAGAGCGCCAAGGTCG
CGCAGAACCTGGCGGTGGTGGAAGAGTTCTCCAGCCTGCTCGAAGTGCTGCCCTACACCGCGAAGGCCGCGTCCCACTAC
GGCGCCATCCGCACGGCGCTGGAGAAGGCAGGGCAACCCATCGGGCTGAACGACCTGCACATCGCGGCCCATGCCCGCAG
CGAGGGGCTCACCCTGGTCACCAACAACCTCGGTGAGTTCGAGCGGGTGCCCGGCTTGCTGGTGGAGAACTGGGTCGGCA
GCCGGACCTGA

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8589.67 Da        Isoelectric Point: 9.0010

>AT22773 WP_012347971.1 NC_010524:c3254052-3253819 [Leptothrix cholodnii SP-6]
MSITSVFTNNRSQAVRLPADLRLPEGVKKVQVRARGLDRIISPVGHTWDSFFLGGPQASEDFMAERASQQQADREAF

Download         Length: 234 bp

>AT22773 NC_010524:c3254052-3253819 [Leptothrix cholodnii SP-6]
ATGAGCATCACATCGGTCTTCACGAACAACCGATCGCAGGCCGTGCGCCTGCCGGCGGATTTGCGACTGCCGGAAGGCGT
CAAGAAGGTGCAGGTGCGCGCCCGCGGCCTGGACCGCATCATCTCGCCGGTGGGTCACACCTGGGACTCGTTCTTCCTGG
GCGGACCGCAGGCCTCCGAGGACTTCATGGCCGAGCGGGCCTCGCAGCAGCAAGCCGACCGCGAGGCCTTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBB1XYH2

References