227728

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 2189830..2190307 Replicon chromosome
Accession NZ_CP089156
Organism Staphylococcus aureus strain UNC_SaCF35

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag LTK19_RS11080 Protein ID WP_000052076.1
Coordinates 2189830..2190018 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag LTK19_RS11085 Protein ID WP_001059690.1
Coordinates 2190047..2190307 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTK19_RS11050 (LTK19_11050) 2185783..2186340 + 558 WP_232043938.1 hypothetical protein -
LTK19_RS11055 (LTK19_11055) 2186681..2187367 + 687 WP_001574556.1 thermonuclease family protein -
LTK19_RS11060 (LTK19_11060) 2187724..2187924 + 201 WP_001059082.1 cold-shock protein -
LTK19_RS11065 (LTK19_11065) 2188421..2188639 - 219 WP_000005879.1 hypothetical protein -
LTK19_RS11070 (LTK19_11070) 2188701..2188985 - 285 WP_001004401.1 hypothetical protein -
LTK19_RS11075 (LTK19_11075) 2189073..2189642 - 570 WP_001106663.1 lipoprotein N-acylation protein LnsA -
LTK19_RS11080 (LTK19_11080) 2189830..2190018 - 189 WP_000052076.1 hypothetical protein Toxin
LTK19_RS11085 (LTK19_11085) 2190047..2190307 - 261 WP_001059690.1 hypothetical protein Antitoxin
LTK19_RS11090 (LTK19_11090) 2190648..2190851 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
LTK19_RS11095 (LTK19_11095) 2190848..2191084 - 237 WP_000368687.1 hypothetical protein -
LTK19_RS11100 (LTK19_11100) 2191309..2191890 + 582 WP_001140696.1 histidine phosphatase family protein -
LTK19_RS11105 (LTK19_11105) 2191963..2192580 - 618 WP_000255545.1 LysE/ArgO family amino acid transporter -
LTK19_RS11110 (LTK19_11110) 2192736..2193230 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
LTK19_RS11115 (LTK19_11115) 2193629..2194051 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
LTK19_RS11120 (LTK19_11120) 2194199..2194915 + 717 WP_000150036.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-69)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T227728 WP_000052076.1 NZ_CP089156:c2190018-2189830 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T227728 NZ_CP123024:2427608-2428930 [Escherichia coli]
ATGCCTAAACTTGTCACTTGGATGAACAACCAGCGGGTAGGCGAGTTAACGAAGTTAGCCAACGGCGCGCACACCTTTAA
GTATGCACCGGAGTGGTTAGCCAGCCGTTATGCCAGACCGTTGTCACTTTCGCTGCCATTGCAGAGGGGGAATATCACCT
CAGATGCCGTATTTAACTTCTTCGATAACCTGTTACCCGATAGCCCGATTGTACGTGACCGGATCGTTAAACGTTATCAT
GCTAAATCCAGACAACCGTTTGATTTATTGTCAGAAATAGGGCGAGACAGCGTTGGTGCCGTAACGTTATTACCCGAAAA
TGAAACCATAACGCGCCCGATAATGGCATGGGAAAAGCTTACTGAAGCCAGGCTTGAAGAAGTATTAACGGCTTATAAAG
CAGATATCCCTCTGGGCATGATTAGAGAAGAAAATGACTTTCGCATCTCGGTTGCTGGCGCGCAGGAGAAGACAGCGCTG
CTTAGAATAGGCAATGACTGGTGCATTCCGAAAGGAATAACGCCGACGACGCACATCATTAAATTACCGATTGGCGAAAT
CAGGCAGCCCAATGCGACGCTCGATCTCAGCCAAAGCGTTGATAATGAGTATTACTGTCTGCTGCTGGCGAAAGAACTTG
GGTTGAATGTTCCGGACGCAGAAATCATTAAAGCGGGAAGGGTGCGCGCGTTAGCGGTCGAACGTTTTGACAGGCGTTGG
AATACTGAGCGAACGGTTTTACTTCGCTTGCCACAGGAGGATATGTGTCAGACATTCGGTTTACCTTCATCTGTGAAATA
TGAATCAGATGGAGGCCCAGGCATCGCGCGGATCATGGCGTTTTTGATGGGGTCCAGCGAGGCGCTTCGCGATCGTTATG
ATTTTATGAAATTCCAGGTCTTCCAGTGGTTGATTGGCGCAACGGATGGCCATGCAAAAAACTTCTCCGTATTTATTCAG
GCTGGCGGCAGTTATCGACTCACGCCATTTTACGACATCATTTCAGCATTTCCGGTCCTTGGCGGTACGGGAATACACAT
CAGCGATCTCAAACTGGCAATGGGGCTTAACGCATCCAAAGGCAAAAAAACGGCAATCGATAAAATTTATCCGCGACATT
TTTTGGCGACAGCAAAGGTGCTGAGATTCCCGGAAGTGCAGATGCATGAAATCCTAAGTGACTTTGCCAGAATGATTCCG
GCAGCACTGGATAACGTGAAGACTTCATTACCGACAGATTTTCCGGAGAACGTGGTGACGGCAGTTGAAACCAATGTGTT
GAGGTTGCATGGACGGTTAAGCCGAGAATACGGTAGTAAGTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT227728 WP_001059690.1 NZ_CP089156:c2190307-2190047 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT227728 NZ_CP123024:2427342-2427608 [Escherichia coli]
ATGATGAGCTTTCAGAAGATCTATAGCCCAACGCAATTAGCGAATGCAATGAAACTGGTTCGCCAGCAAAATGGCTGGAC
GCAGAGCGAGCTGGCGAAAAAAATTGGCATTAAGCAGGCGACAATTTCCAATTTCGAAAACAACCCTGACAATACCACGC
TCACGACATTTTTTAAGATTTTACAGTCGCTTGAACTCTCAATGACACTATGCGACACGAAAAATGCCTCGCCAGAATCA
ACAGAACAGCAAGATCTGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References