Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 685248..685762 Replicon chromosome
Accession NZ_CP089156
Organism Staphylococcus aureus strain UNC_SaCF35

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag LTK19_RS03805 Protein ID WP_000581791.1
Coordinates 685248..685457 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag LTK19_RS03810 Protein ID WP_000138934.1
Coordinates 685469..685762 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTK19_RS03785 (LTK19_03785) 681137..682207 - 1071 WP_000159639.1 D-alanine--D-alanine ligase -
LTK19_RS03790 (LTK19_03790) 682525..683727 + 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
LTK19_RS03795 (LTK19_03795) 683888..684571 - 684 Protein_715 transposase -
LTK19_RS03800 (LTK19_03800) 684983..685120 - 138 WP_000828354.1 Lmo0850 family protein -
LTK19_RS03805 (LTK19_03805) 685248..685457 - 210 WP_000581791.1 heavy metal-associated domain-containing protein Toxin
LTK19_RS03810 (LTK19_03810) 685469..685762 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
LTK19_RS03815 (LTK19_03815) 685928..687412 + 1485 WP_000571560.1 cardiolipin synthase -
LTK19_RS03820 (LTK19_03820) 687440..688087 + 648 WP_001187612.1 HD domain-containing protein -
LTK19_RS03825 (LTK19_03825) 688244..688543 + 300 WP_001793952.1 hypothetical protein -
LTK19_RS03830 (LTK19_03830) 688700..689572 - 873 WP_000725802.1 membrane protein insertase YidC -
LTK19_RS03835 (LTK19_03835) 689658..690299 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T227723 WP_000581791.1 NZ_CP089156:c685457-685248 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T227723 NZ_CP123024:1344785-1345183 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTTATTGAAGGTTTCGTATCTCGTTTGGTAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGACTGGAGCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT227723 WP_000138934.1 NZ_CP089156:c685762-685469 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT227723 NZ_CP123024:1344558-1344785 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAAGACGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References