Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 677323..677906 Replicon chromosome
Accession NC_010524
Organism Leptothrix cholodnii SP-6

Toxin (Protein)


Gene name vapC Uniprot ID B1XZQ9
Locus tag LCHO_RS03165 Protein ID WP_012345667.1
Coordinates 677323..677703 (-) Length 127 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B1XZR0
Locus tag LCHO_RS03170 Protein ID WP_012345668.1
Coordinates 677700..677906 (-) Length 69 a.a.

Genomic Context

LCHO_RS03140LCHO_RS03145LCHO_RS22530LCHO_RS03150LCHO_RS03160LCHO_RS23260LCHO_RS03155LCHO_RS03165LCHO_RS03170
Location: 672652..673578 (927 bp)
Type: Others
Protein ID: WP_012345661.1
Location: 673587..673814 (228 bp)
Type: Others
Protein ID: WP_012345662.1
Location: 673811..674074 (264 bp)
Type: Others
Protein ID: WP_012345663.1
Location: 674216..675340 (1125 bp)
Type: Others
Protein ID: WP_012345664.1
Location: 676061..677287 (1227 bp)
Type: Others
Protein ID: WP_012345666.1
Location: 678225..682472 (4248 bp)
Type: Others
Protein ID: WP_012345669.1
Location: 675375..675965 (591 bp)
Type: Others
Protein ID: WP_012345665.1
Location: 677323..677703 (381 bp)
Type: Toxin
Protein ID: WP_012345667.1
Location: 677700..677906 (207 bp)
Type: Antitoxin
Protein ID: WP_012345668.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LCHO_RS03140672652..673578+927WP_012345661.1GDP-L-fucose synthase-
LCHO_RS03145673587..673814+228WP_012345662.1hypothetical protein-
LCHO_RS22530673811..674074+264WP_012345663.1PIN domain-containing protein-
LCHO_RS03150674216..675340+1125WP_012345664.1GDP-mannose 4,6-dehydratase-
LCHO_RS03155675375..675965-591WP_012345665.1Uma2 family endonuclease-
LCHO_RS03160676061..677287+1227WP_012345666.1glycosyltransferase family 4 protein-
LCHO_RS03165677323..677703-381WP_012345667.1type II toxin-antitoxin system VapC family toxinToxin
LCHO_RS03170677700..677906-207WP_012345668.1type II toxin-antitoxin system VapB family antitoxinAntitoxin
LCHO_RS23260678225..682472+4248WP_012345669.1Na-Ca exchanger/integrin-beta4-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-114)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-43)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 13924.23 Da        Isoelectric Point: 5.1780

>T22772 WP_012345667.1 NC_010524:c677703-677323 [Leptothrix cholodnii SP-6]
MNVLVDTSVWVGHFKQRNERLVALLEAGLVVCHPYVVVEIACGTPPGWQSIIEMLAELESVPVAAPDELRALIERRALFG
RGCGFVDVSLLASALLKDQTRIWTLDKRLEAVAAELDRAYRPALQS

Download         Length: 381 bp

>T22772 NC_010524:c677703-677323 [Leptothrix cholodnii SP-6]
ATGAACGTGCTCGTCGACACCTCCGTATGGGTCGGGCACTTCAAGCAGCGCAACGAGCGGCTCGTGGCGCTGCTTGAAGC
AGGCCTGGTCGTGTGCCACCCGTACGTCGTGGTGGAAATCGCTTGCGGGACACCCCCTGGCTGGCAATCCATCATCGAGA
TGCTGGCTGAGCTTGAAAGCGTGCCGGTCGCGGCGCCCGACGAACTGCGGGCCCTGATTGAGCGCCGAGCGCTCTTCGGC
CGCGGGTGTGGTTTCGTCGACGTCAGCCTGCTGGCCTCCGCACTGCTCAAGGACCAGACCCGGATCTGGACCTTGGACAA
ACGGCTTGAGGCGGTGGCCGCCGAGTTGGATCGGGCCTACCGTCCAGCGCTGCAGTCCTGA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7424.52 Da        Isoelectric Point: 6.2525

>AT22772 WP_012345668.1 NC_010524:c677906-677700 [Leptothrix cholodnii SP-6]
MRTTLTIDDELFAKAVSLAAPGIEKSELLKECVKAFIQQQTARRLAALGGQAPDIDLAPRRRDETPTS

Download         Length: 207 bp

>AT22772 NC_010524:c677906-677700 [Leptothrix cholodnii SP-6]
ATGCGGACCACACTCACGATTGATGACGAACTCTTTGCCAAGGCTGTTTCGCTGGCAGCGCCCGGGATCGAGAAGTCCGA
GTTGCTGAAGGAGTGCGTCAAGGCCTTCATCCAGCAGCAGACCGCTCGGCGCCTGGCAGCCCTGGGTGGCCAGGCCCCGG
ACATCGACCTTGCTCCGCGCCGGCGCGACGAAACACCGACCTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBB1XZQ9

Antitoxin

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Source
ID
Structure
AlphaFold DBB1XZR0

References