Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 1359783..1360260 Replicon chromosome
Accession NZ_CP089154
Organism Staphylococcus aureus strain UNC_SaCF36

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag LTK15_RS06965 Protein ID WP_000052076.1
Coordinates 1360072..1360260 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag LTK15_RS06960 Protein ID WP_001059690.1
Coordinates 1359783..1360043 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTK15_RS06925 (1355176) 1355176..1355892 - 717 WP_000150033.1 type I 3-dehydroquinate dehydratase -
LTK15_RS06930 (1356040) 1356040..1356462 + 423 WP_000974451.1 organic hydroperoxide resistance protein -
LTK15_RS06935 (1356861) 1356861..1357355 + 495 WP_000569884.1 GNAT family N-acetyltransferase -
LTK15_RS06940 (1357511) 1357511..1358128 + 618 WP_000255550.1 LysE/ArgO family amino acid transporter -
LTK15_RS06945 (1358201) 1358201..1358782 - 582 WP_001140696.1 histidine phosphatase family protein -
LTK15_RS06950 (1359006) 1359006..1359242 + 237 WP_000368687.1 hypothetical protein -
LTK15_RS06955 (1359239) 1359239..1359442 - 204 WP_000145160.1 sterile alpha motif-like domain-containing protein -
LTK15_RS06960 (1359783) 1359783..1360043 + 261 WP_001059690.1 hypothetical protein Antitoxin
LTK15_RS06965 (1360072) 1360072..1360260 + 189 WP_000052076.1 hypothetical protein Toxin
LTK15_RS06970 (1360448) 1360448..1361017 + 570 WP_001106662.1 lipoprotein N-acylation protein LnsA -
LTK15_RS06975 (1361105) 1361105..1361377 + 273 WP_001004400.1 hypothetical protein -
LTK15_RS06980 (1361450) 1361450..1361668 + 219 WP_000005875.1 hypothetical protein -
LTK15_RS06985 (1362165) 1362165..1362365 - 201 WP_001059082.1 cold-shock protein -
LTK15_RS06990 (1362722) 1362722..1363408 - 687 WP_001622483.1 thermonuclease family protein -
LTK15_RS06995 (1363749) 1363749..1364270 - 522 WP_000824479.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(4-44)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T227711 WP_000052076.1 NZ_CP089154:1360072-1360260 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

>T227711 NZ_CP123019:c44219-44085 [Escherichia coli]
ATGACGAAATATACCCTTATCGGGTTGCTTGCCGTGTGCGCCACGGTGTTGTGTTTTTCACTGATATTCAGGGAACAGTT
ATGTGAACTGAATATTCACAGGGGAAATACAGTGGTGCAGGTAACTCTGGCCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT227711 WP_001059690.1 NZ_CP089154:1359783-1360043 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp

>AT227711 NZ_CP123019:44264-44324 [Escherichia coli]
TAAAGTGCATCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References