Detailed information of TA system TA022771

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1846733..1847332
• Replicon: chromosome
• Accession: NC_010519
• Organism: Haemophilus somnus 2336

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B0UV74
• Locus tag: HSM_RS08220
• Protein ID: WP_012340732.1
• Coordinates: 1846733..1847038 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B0UV75
• Locus tag: HSM_RS08225
• Protein ID: WP_012340733.1
• Coordinates: 1847042..1847332 (-)
• Length: 97 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HSM_RS08205	1842083..1842943	+	861	WP_011609333.1	RNase adapter RapZ	-
HSM_RS08210	1842979..1845030	-	2052	WP_012340730.1	methionine--tRNA ligase	-
HSM_RS08215	1845171..1846292	+	1122	WP_012340731.1	iron-sulfur cluster carrier protein ApbC	-
HSM_RS10655	1846276..1846512	-	237	WP_080514392.1	recombinase family protein	-
HSM_RS08220	1846733..1847038	-	306	WP_012340732.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
HSM_RS08225	1847042..1847332	-	291	WP_012340733.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
HSM_RS08230	1847504..1848067	-	564	WP_178384292.1	molecular chaperone	-
HSM_RS08235	1848064..1848684	-	621	WP_011608731.1	NAD(P)H-dependent oxidoreductase	-
HSM_RS08240	1848694..1849137	-	444	WP_012340735.1	NfeD family protein	-
HSM_RS08245	1849184..1850104	-	921	WP_011608729.1	SPFH/Band 7/PHB domain protein	-
HSM_RS08250	1850387..1850839	+	453	WP_011608728.1	type II 3-dehydroquinate dehydratase	-
HSM_RS08255	1851028..1851489	+	462	WP_012340736.1	acetyl-CoA carboxylase biotin carboxyl carrier protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (5-97)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (4-84)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11745.47 Da
• Isoelectric Point: 8.9207

>T22771 WP_012340732.1 NC_010519:c1847038-1846733 [Histophilus somni 2336]
MSGKQLKVSYSKQFARDLTDLAKRYPNVLVGTKYITAMHCLLNRLPLPESYQDHTLVGEWKGYRDCHIQGDLVLIYQYVI
HDEFDALKFSRLNTYSQTASK

Nucleotide

• Length: 306 bp

>T22771 NC_010519:c1847038-1846733 [Histophilus somni 2336]
ATGTCTGGTAAACAATTAAAGGTCAGTTACTCTAAACAATTTGCTAGAGATTTGACTGATTTGGCAAAACGTTACCCAAA
TGTGCTAGTAGGAACGAAATATATTACAGCAATGCACTGCTTGTTAAACCGCTTGCCATTGCCTGAAAGCTATCAAGATC
ACACATTAGTTGGAGAATGGAAAGGTTATCGAGATTGCCATATTCAAGGGGATTTGGTGCTGATTTACCAATACGTTATA
CACGATGAATTTGATGCGTTGAAATTTTCTCGTTTAAATACCTACTCGCAAACAGCTTCAAAATAG

Antitoxin

Protein

• Length: 97 a.a.
• Molecular weight: 10804.13 Da
• Isoelectric Point: 4.2845

>AT22771 WP_012340733.1 NC_010519:c1847332-1847042 [Histophilus somni 2336]
MALTNASISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPVDLNYLRPNKETLAAMDELDSGNAESFFIEA
GENYSVEEFTKRILNG

Nucleotide

• Length: 291 bp

>AT22771 NC_010519:c1847332-1847042 [Histophilus somni 2336]
ATGGCACTTACAAATGCGTCTATCAGCTTTAGAACAGTTGAGCAAACTAAATCCGAAGCCTATCAGGTCATTGAACAATA
TGGTCTTACACCATCACAAGTATTTAATATGTTTTTGGCTCAAATTGCCAAGACTCGCTCTATCCCTGTTGATTTGAATT
ATCTTCGCCCAAATAAAGAAACCTTAGCAGCTATGGACGAATTAGATAGCGGTAATGCAGAGAGCTTTTTTATTGAAGCT
GGAGAAAATTATTCTGTCGAAGAGTTTACAAAACGCATTCTTAACGGGTAA

Structures

Toxin

• AlphaFold DB: B0UV74

Antitoxin

• AlphaFold DB: B0UV75