Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_XRE(antitoxin) |
| Location | 270108..270905 | Replicon | chromosome |
| Accession | NZ_CP089154 | ||
| Organism | Staphylococcus aureus strain UNC_SaCF36 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | - |
| Locus tag | LTK15_RS01465 | Protein ID | WP_000525008.1 |
| Coordinates | 270108..270569 (-) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0C2LD36 |
| Locus tag | LTK15_RS01470 | Protein ID | WP_001260487.1 |
| Coordinates | 270582..270905 (-) | Length | 108 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LTK15_RS01440 (265841) | 265841..266371 | + | 531 | WP_000184383.1 | acyl-CoA thioesterase | - |
| LTK15_RS01445 (266634) | 266634..267779 | - | 1146 | WP_033858404.1 | radical SAM/CxCxxxxC motif protein YfkAB | - |
| LTK15_RS01450 (267824) | 267824..268870 | - | 1047 | WP_001145732.1 | tyrosine-type recombinase/integrase | - |
| LTK15_RS01455 (268940) | 268940..269410 | - | 471 | WP_000183249.1 | hypothetical protein | - |
| LTK15_RS01460 (269403) | 269403..269924 | - | 522 | WP_001102444.1 | hypothetical protein | - |
| LTK15_RS01465 (270108) | 270108..270569 | - | 462 | WP_000525008.1 | hypothetical protein | Toxin |
| LTK15_RS01470 (270582) | 270582..270905 | - | 324 | WP_001260487.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| LTK15_RS01475 (271069) | 271069..271317 | + | 249 | WP_000272859.1 | helix-turn-helix transcriptional regulator | - |
| LTK15_RS01480 (271330) | 271330..271773 | + | 444 | WP_000435356.1 | hypothetical protein | - |
| LTK15_RS01485 (271788) | 271788..271967 | + | 180 | WP_000393082.1 | hypothetical protein | - |
| LTK15_RS01490 (271957) | 271957..272196 | - | 240 | WP_000438628.1 | hypothetical protein | - |
| LTK15_RS01495 (272253) | 272253..273044 | + | 792 | WP_001157019.1 | phage antirepressor KilAC domain-containing protein | - |
| LTK15_RS01500 (273045) | 273045..273269 | + | 225 | WP_000187184.1 | hypothetical protein | - |
| LTK15_RS01505 (273309) | 273309..273758 | + | 450 | WP_000993183.1 | hypothetical protein | - |
| LTK15_RS01510 (273772) | 273772..273987 | + | 216 | WP_025175692.1 | hypothetical protein | - |
| LTK15_RS01515 (273980) | 273980..274141 | + | 162 | WP_000048124.1 | DUF1270 family protein | - |
| LTK15_RS01520 (274234) | 274234..274536 | + | 303 | WP_000163430.1 | DUF2482 family protein | - |
| LTK15_RS01525 (274541) | 274541..274801 | + | 261 | WP_000291481.1 | DUF1108 family protein | - |
| LTK15_RS01530 (274811) | 274811..275062 | + | 252 | WP_000683290.1 | hypothetical protein | - |
| LTK15_RS01535 (275055) | 275055..275588 | + | 534 | WP_001004326.1 | host-nuclease inhibitor Gam family protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 267824..311928 | 44104 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18034.35 Da Isoelectric Point: 4.6899
>T227709 WP_000525008.1 NZ_CP089154:c270569-270108 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T227709 NZ_CP123017:3605171-3605389 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTTTGGAAATTTATTCGCTAA
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTTTGGAAATTTATTCGCTAA
Antitoxin
Download Length: 108 a.a. Molecular weight: 12431.09 Da Isoelectric Point: 9.3811
>AT227709 WP_001260487.1 NZ_CP089154:c270905-270582 [Staphylococcus aureus]
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
MRTSAEIGKLIKQLRKENNVNLTDFATKIGVNKSTLSRYENGSRKIPMEDIAEIANALKVTPEYLLLKNRQTENEVQHRA
AHLEGELTDDEWQRVLDYADYIRSKRK
Download Length: 324 bp
>AT227709 NZ_CP123017:3604771-3605145 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|