Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 84359..84873 Replicon chromosome
Accession NZ_CP089154
Organism Staphylococcus aureus strain UNC_SaCF36

Toxin (Protein)


Gene name TsdT Uniprot ID A0A0U1MQX5
Locus tag LTK15_RS00415 Protein ID WP_000581795.1
Coordinates 84664..84873 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0U1MQV0
Locus tag LTK15_RS00410 Protein ID WP_000138930.1
Coordinates 84359..84652 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LTK15_RS00390 (79885) 79885..80526 + 642 WP_000483162.1 thiamine phosphate synthase -
LTK15_RS00395 (80612) 80612..81484 + 873 WP_000725802.1 membrane protein insertase YidC -
LTK15_RS00400 (82034) 82034..82681 - 648 WP_001187625.1 HD domain-containing protein -
LTK15_RS00405 (82709) 82709..84193 - 1485 WP_000571562.1 cardiolipin synthase -
LTK15_RS00410 (84359) 84359..84652 + 294 WP_000138930.1 copper-sensing transcriptional repressor CsoR Antitoxin
LTK15_RS00415 (84664) 84664..84873 + 210 WP_000581795.1 heavy metal-associated domain-containing protein Toxin
LTK15_RS00420 (85001) 85001..85138 + 138 WP_000828354.1 Lmo0850 family protein -
LTK15_RS00425 (85402) 85402..86604 - 1203 WP_001109939.1 FtsW/RodA/SpoVE family cell cycle protein -
LTK15_RS00430 (86922) 86922..87992 + 1071 WP_000159641.1 D-alanine--D-alanine ligase -
LTK15_RS00435 (88007) 88007..89365 + 1359 WP_000611479.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-92)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7842.83 Da        Isoelectric Point: 4.3869

>T227703 WP_000581795.1 NZ_CP089154:84664-84873 [Staphylococcus aureus]
MIHQNTIYTAGIETKEQVSQLTERISNMIGVHQVNINIIDGQVTVSYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

>T227703 NZ_CP123017:2109075-2109178 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11169.81 Da        Isoelectric Point: 6.2242

>AT227703 WP_000138930.1 NZ_CP089154:84359-84652 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVKAINRMIEEDVYCDDVLTQIRATRSALNSVAIKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp

>AT227703 NZ_CP123017:c2109216-2108945 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0U1MQX5

Antitoxin

Source ID Structure
AlphaFold DB A0A0U1MQV0

References