Detailed information of TA system TA022769

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 1022474..1023095
• Replicon: chromosome
• Accession: NC_010519
• Organism: Haemophilus somnus 2336

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: -
• Locus tag: HSM_RS04610
• Protein ID: WP_011609549.1
• Coordinates: 1022910..1023095 (-)
• Length: 62 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: B0USX2
• Locus tag: HSM_RS04605
• Protein ID: WP_012341699.1
• Coordinates: 1022474..1022887 (-)
• Length: 138 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
HSM_RS04570	1018118..1018345	+	228	WP_012341693.1	hypothetical protein	-
HSM_RS04575	1018498..1018737	+	240	WP_012341694.1	helix-turn-helix domain-containing protein	-
HSM_RS04580	1018727..1019551	+	825	WP_012341695.1	hypothetical protein	-
HSM_RS04585	1019548..1020240	+	693	WP_011609555.1	replication protein P	-
HSM_RS04590	1020255..1020788	+	534	WP_012341696.1	phage N-6-adenine-methyltransferase	-
HSM_RS04595	1020801..1021253	+	453	WP_012341697.1	DUF1367 family protein	-
HSM_RS04600	1021305..1021919	-	615	WP_012341698.1	hypothetical protein	-
HSM_RS04605	1022474..1022887	-	414	WP_012341699.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
HSM_RS04610	1022910..1023095	-	186	WP_011609549.1	type II toxin-antitoxin system HicA family toxin	Toxin
HSM_RS04615	1023286..1023864	+	579	WP_012341702.1	recombination protein NinG	-
HSM_RS04620	1023854..1024258	+	405	WP_041605056.1	hypothetical protein	-
HSM_RS04625	1024492..1024872	-	381	WP_041605264.1	type II toxin-antitoxin system PemK/MazF family toxin	-
HSM_RS04630	1025178..1025414	+	237	WP_012341704.1	hypothetical protein	-
HSM_RS04635	1025407..1025943	+	537	WP_011609542.1	lysozyme	-
HSM_RS04640	1025916..1026245	+	330	WP_012341706.1	DUF2570 family protein	-
HSM_RS04645	1026199..1026417	+	219	WP_041605057.1	hypothetical protein	-
HSM_RS04650	1026442..1027137	+	696	WP_012341707.1	terminase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	999788..1054251	54463

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (5-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-130)

Sequences

Toxin

Protein

• Length: 62 a.a.
• Molecular weight: 6871.87 Da
• Isoelectric Point: 10.7967

>T22769 WP_011609549.1 NC_010519:c1023095-1022910 [Histophilus somni 2336]
VSSSKQIIKRIEADGWKFHHATGSHHHFTHPTKKGIVTVQHPEKDLKKGTEHSILKQAGLK

Nucleotide

• Length: 186 bp

>T22769 NC_010519:c1023095-1022910 [Histophilus somni 2336]
GTGAGTAGTAGCAAACAAATTATTAAACGGATTGAAGCGGACGGCTGGAAATTCCACCACGCAACAGGAAGCCACCACCA
CTTCACTCATCCAACCAAAAAAGGGATTGTTACCGTCCAACATCCTGAAAAGGATTTAAAAAAAGGAACGGAACATTCAA
TACTTAAACAAGCGGGGCTGAAATAG

Antitoxin

Protein

• Length: 138 a.a.
• Molecular weight: 15188.31 Da
• Isoelectric Point: 4.5591

>AT22769 WP_012341699.1 NC_010519:c1022887-1022474 [Histophilus somni 2336]
MLYPIAIEPGDETHAFGVIVPDIPGCHSAGDTLEEAYANAKEAIKGHLELLVEMGEEVPLPTSINNHRQNPDFTEYDMFF
GFVDVDITHLLGKAEKINITMPAYLIKRIDEFVATHKEYKSRSGFLAQIAADKILSA

Nucleotide

• Length: 414 bp

>AT22769 NC_010519:c1022887-1022474 [Histophilus somni 2336]
ATGTTATATCCAATCGCAATCGAACCGGGCGATGAAACTCACGCATTCGGCGTTATCGTCCCTGATATTCCGGGGTGCCA
TTCTGCCGGTGATACTTTGGAAGAAGCCTATGCTAACGCCAAAGAAGCCATCAAAGGGCATTTGGAATTATTGGTTGAAA
TGGGCGAAGAAGTTCCATTACCAACCTCAATCAATAACCACCGCCAAAATCCCGACTTTACCGAGTACGATATGTTCTTC
GGTTTCGTTGATGTTGATATTACTCACCTCTTAGGCAAAGCCGAAAAAATCAACATCACAATGCCTGCTTATCTCATCAA
GCGTATTGATGAATTTGTGGCAACGCATAAAGAGTACAAAAGCCGTAGCGGTTTCTTGGCTCAAATCGCCGCTGACAAGA
TTTTATCGGCTTAA

Structures

Antitoxin

• AlphaFold DB: B0USX2