Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 3016772..3017411 Replicon chromosome
Accession NC_010515
Organism Burkholderia cenocepacia MC0-3

Toxin (Protein)


Gene name vapC Uniprot ID A0A3N9F707
Locus tag BCENMC03_RS29210 Protein ID WP_011547639.1
Coordinates 3017001..3017411 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B1K469
Locus tag BCENMC03_RS29205 Protein ID WP_011547638.1
Coordinates 3016772..3017008 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCENMC03_RS38830 3012089..3012409 + 321 WP_175813786.1 hypothetical protein -
BCENMC03_RS37395 3012519..3013208 - 690 WP_171984323.1 hypothetical protein -
BCENMC03_RS38420 3013778..3013999 - 222 WP_027811879.1 hypothetical protein -
BCENMC03_RS29195 3014358..3015035 + 678 WP_012339913.1 hypothetical protein -
BCENMC03_RS29200 3015055..3016281 - 1227 WP_012339914.1 acyltransferase -
BCENMC03_RS29205 3016772..3017008 + 237 WP_011547638.1 DNA-binding protein Antitoxin
BCENMC03_RS29210 3017001..3017411 + 411 WP_011547639.1 type II toxin-antitoxin system VapC family toxin Toxin
BCENMC03_RS29215 3017825..3018028 + 204 WP_006483056.1 cold-shock protein -
BCENMC03_RS29220 3018495..3018758 + 264 WP_006483034.1 translation initiation factor IF-1 -
BCENMC03_RS29225 3019328..3020575 + 1248 WP_012339915.1 alkaline phosphatase family protein -
BCENMC03_RS29230 3020572..3020820 + 249 WP_011547641.1 hypothetical protein -
BCENMC03_RS29235 3020861..3022231 - 1371 WP_012339916.1 MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15202.37 Da        Isoelectric Point: 6.8816

>T22766 WP_011547639.1 NC_010515:3017001-3017411 [Burkholderia cenocepacia MC0-3]
MIDTNVISEIRKGRRTNRGVRAFFRQAEADASPLYLSVVTVAELRRGVDLIRHRGDHSQASALEAWIAMILSGYAPNILP
VDIETSQMWGHLRVPDPTHELDKLIAATALINDLTVVTRNVDDFARTGVRLLNPFD

Download         Length: 411 bp

>T22766 NC_010515:3017001-3017411 [Burkholderia cenocepacia MC0-3]
TTGATTGATACGAACGTCATCAGCGAAATCAGGAAGGGCAGGCGAACCAATCGCGGCGTGCGGGCGTTCTTCAGGCAGGC
CGAAGCCGACGCGAGCCCGCTTTACCTGTCCGTCGTGACGGTGGCCGAGTTGCGGCGCGGCGTCGACCTGATCCGTCATC
GCGGCGATCATAGCCAGGCGTCGGCGCTCGAGGCCTGGATCGCGATGATCCTGTCGGGCTATGCGCCGAACATCCTGCCG
GTCGATATCGAGACCAGCCAGATGTGGGGGCATTTGCGGGTGCCCGATCCGACGCACGAACTCGACAAGCTGATCGCGGC
CACCGCGCTGATCAACGATCTGACGGTCGTCACGCGCAACGTCGACGATTTCGCTCGCACTGGCGTCCGGTTGCTGAATC
CGTTCGACTAG

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8692.75 Da        Isoelectric Point: 5.0916

>AT22766 WP_011547638.1 NC_010515:3016772-3017008 [Burkholderia cenocepacia MC0-3]
MANLLVRNVDDTIVQSLREQAAANGRSAEAEHRAILAEALGRPKRRTFAQVLLSMPEVGEDADFQRVQDSGEVRRVFD

Download         Length: 237 bp

>AT22766 NC_010515:3016772-3017008 [Burkholderia cenocepacia MC0-3]
ATGGCAAATCTTCTGGTGCGTAACGTGGATGACACTATCGTTCAAAGCCTGCGTGAGCAGGCGGCGGCCAATGGCAGGAG
CGCCGAGGCCGAACATCGAGCCATTCTGGCCGAAGCGCTCGGCCGGCCGAAGCGGCGGACATTTGCTCAAGTGCTGCTGA
GCATGCCGGAGGTGGGCGAGGACGCGGATTTCCAACGTGTTCAGGATTCAGGCGAGGTCAGGCGTGTTTTTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3N9F707

Antitoxin

Source ID Structure
AlphaFold DB B1K469

References