Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2736328..2738099 Replicon chromosome
Accession NC_010515
Organism Burkholderia cenocepacia MC0-3

Toxin (Protein)


Gene name doc Uniprot ID B1K293
Locus tag BCENMC03_RS28005 Protein ID WP_011547425.1
Coordinates 2736328..2737245 (+) Length 306 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID B1K294
Locus tag BCENMC03_RS28010 Protein ID WP_011547426.1
Coordinates 2737242..2738099 (+) Length 286 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCENMC03_RS27975 2731699..2732778 - 1080 WP_012339772.1 porin -
BCENMC03_RS27980 2733223..2733540 + 318 WP_006478721.1 non-heme iron oxygenase ferredoxin subunit -
BCENMC03_RS27985 2733542..2733853 + 312 WP_006478722.1 hypothetical protein -
BCENMC03_RS27990 2733914..2734984 + 1071 WP_012339773.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
BCENMC03_RS27995 2734977..2735747 + 771 WP_011547423.1 SDR family oxidoreductase -
BCENMC03_RS28000 2735782..2736309 + 528 WP_011547424.1 cupin domain-containing protein -
BCENMC03_RS28005 2736328..2737245 + 918 WP_011547425.1 alpha/beta hydrolase Toxin
BCENMC03_RS28010 2737242..2738099 + 858 WP_011547426.1 IclR family transcriptional regulator Antitoxin
BCENMC03_RS28015 2738096..2738893 + 798 WP_011547427.1 SDR family oxidoreductase -
BCENMC03_RS28020 2738886..2740553 + 1668 WP_012339774.1 thiamine pyrophosphate-binding protein -
BCENMC03_RS28025 2740546..2741373 + 828 WP_011547429.1 aspartate dehydrogenase -
BCENMC03_RS28030 2741446..2742936 + 1491 WP_012339775.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(58-286)

Antitoxin

Transcription regulator IclR, N-terminal

(24-72)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 31280.60 Da        Isoelectric Point: 7.7325

>T22765 WP_011547425.1 NC_010515:2736328-2737245 [Burkholderia cenocepacia MC0-3]
MSVIDKRERERDRTAAFAALLGQFPEQRCAAGAAGAIGYREAGAGEAGAQHAGRALPVVLLHGIGSGAASWVRQLDTLGA
SRRVLAWDAPGYGVSTPVHGASPAAADYAASLNAWLEALGIERCVLVGHSLGAIIAGGLVRVMPARIAGLLLISPAGGYG
SAPAETRESRRDARLAMLAELGPAGLAEQRSGNMLSGFANEEAKAWVRWNMARIVPAGYAQATHLLANADLAADLAGFRG
RTAVAVGANDAITPPAACERIAAAAHVGLQVIPQAGHAGYVEAPAVYSALIDTFCRQCDPQRGPA

Download         Length: 918 bp

>T22765 NC_010515:2736328-2737245 [Burkholderia cenocepacia MC0-3]
ATGAGTGTCATCGACAAACGCGAACGTGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAGTTTCCCGAGCA
GCGTTGCGCGGCCGGCGCGGCGGGCGCGATCGGCTACCGTGAGGCGGGTGCAGGCGAGGCCGGCGCGCAGCATGCGGGCC
GTGCGCTGCCCGTCGTGCTGCTGCACGGGATCGGCTCGGGCGCCGCATCGTGGGTCCGCCAGCTCGACACGCTGGGTGCA
TCGCGGCGCGTACTCGCGTGGGATGCGCCCGGTTACGGCGTGTCGACGCCCGTGCACGGCGCGTCGCCGGCCGCCGCCGA
TTACGCGGCATCGCTGAACGCGTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGTCATTCGCTCGGCGCGA
TCATCGCGGGCGGCCTCGTCCGCGTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGATTTCGCCCGCGGGCGGCTACGGC
AGCGCACCGGCCGAGACCCGCGAATCGCGCCGCGACGCGCGGCTCGCGATGCTCGCGGAACTCGGCCCGGCCGGGCTCGC
CGAGCAGCGCAGCGGCAACATGCTGTCCGGTTTCGCGAACGAGGAGGCAAAGGCATGGGTGCGCTGGAACATGGCGCGCA
TCGTGCCGGCCGGCTACGCGCAGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGGCCGATCTCGCCGGCTTTCGCGGC
CGCACGGCCGTGGCCGTCGGCGCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCCGCGGCCGCGCACGT
CGGGCTGCAGGTGATTCCGCAGGCGGGGCATGCCGGCTACGTGGAAGCGCCGGCCGTTTATTCCGCGCTGATCGACACGT
TCTGTCGTCAGTGCGACCCACAGCGGGGGCCGGCATGA

Antitoxin


Download         Length: 286 a.a.        Molecular weight: 31315.76 Da        Isoelectric Point: 6.5054

>AT22765 WP_011547426.1 NC_010515:2737242-2738099 [Burkholderia cenocepacia MC0-3]
MSEPLQQNESDNAKAEASYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYK
LGIAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTTHIVIRDGRDVVFVAKAQSQSPVFSSIRVNVGTRLPAHATTHGH
VLMGDLSLKELHALYPEGALNRMTSATPETVDALYDVIREDALRGYGVSNSSFERGISVVTAPVRNETQKIVACITVTVP
RPEIDAALIADGLIDKVQRAAAELSRRLNYRSDDEHTFLKALGLR

Download         Length: 858 bp

>AT22765 NC_010515:2737242-2738099 [Burkholderia cenocepacia MC0-3]
ATGAGCGAACCGCTGCAACAAAACGAATCCGACAACGCGAAGGCCGAAGCCAGCTACGTCGTGCCGGGCCTCGAACGCGG
GCTGCGGATTCTCGCCGAATTCTCGCCGCGCGAGCCCGTGCTCGGCGCGCCCGAACTGTCGAAACGGCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGTTTTCTCGAACGCGCGGACAAGGATCGCAACTACAAG
CTCGGCATCGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGCTGACCGATCTCGGCCTGCCGGTGATCGA
GAGCCTGCGCGACGCGACCGGCTTCACGACGCACATCGTGATTCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGAGCCAGTCGCCGGTGTTCAGCTCGATCCGCGTGAACGTCGGCACCCGGCTGCCCGCGCACGCGACGACGCACGGCCAC
GTGCTGATGGGCGACCTGTCGCTGAAGGAACTGCACGCGCTGTATCCGGAAGGCGCGCTGAACCGGATGACGAGCGCGAC
GCCGGAGACGGTTGACGCGCTGTACGACGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGGATCTCGGTCGTCACGGCGCCGGTGCGCAACGAGACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGTCCGGAGATCGACGCGGCGCTGATCGCGGACGGGCTGATCGACAAGGTGCAGCGCGCGGCGGCGGAATTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTCTCAAAGCTTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B1K293

Antitoxin

Source ID Structure
AlphaFold DB B1K294

References