Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/LOTUS_5_Limkain_b1(toxin) |
Location | 5222801..5223426 | Replicon | chromosome |
Accession | NZ_CP089097 | ||
Organism | Klebsiella pneumoniae strain EH13 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | R4Y4A3 |
Locus tag | LSG42_RS25530 | Protein ID | WP_002882817.1 |
Coordinates | 5222801..5223184 (-) | Length | 128 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | J2DFR0 |
Locus tag | LSG42_RS25535 | Protein ID | WP_004150355.1 |
Coordinates | 5223184..5223426 (-) | Length | 81 a.a. |
Genomic Context
Location: 5220167..5221069 (903 bp)
Type: Others
Protein ID: WP_002882822.1
Type: Others
Protein ID: WP_002882822.1
Location: 5221066..5221701 (636 bp)
Type: Others
Protein ID: WP_002882818.1
Type: Others
Protein ID: WP_002882818.1
Location: 5221698..5222627 (930 bp)
Type: Others
Protein ID: WP_004146237.1
Type: Others
Protein ID: WP_004146237.1
Location: 5223631..5224548 (918 bp)
Type: Others
Protein ID: WP_032437446.1
Type: Others
Protein ID: WP_032437446.1
Location: 5222801..5223184 (384 bp)
Type: Toxin
Protein ID: WP_002882817.1
Type: Toxin
Protein ID: WP_002882817.1
Location: 5223184..5223426 (243 bp)
Type: Antitoxin
Protein ID: WP_004150355.1
Type: Antitoxin
Protein ID: WP_004150355.1
Location: 5224562..5225503 (942 bp)
Type: Others
Protein ID: WP_012543287.1
Type: Others
Protein ID: WP_012543287.1
Location: 5225548..5225985 (438 bp)
Type: Others
Protein ID: WP_002882809.1
Type: Others
Protein ID: WP_002882809.1
Location: 5225982..5226842 (861 bp)
Type: Others
Protein ID: WP_004146232.1
Type: Others
Protein ID: WP_004146232.1
Location: 5226836..5227435 (600 bp)
Type: Others
Protein ID: WP_004151865.1
Type: Others
Protein ID: WP_004151865.1
Loading, please wait
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
LSG42_RS25515 (LSG42_25515) | 5220167..5221069 | + | 903 | WP_002882822.1 | formate dehydrogenase subunit beta | - |
LSG42_RS25520 (LSG42_25520) | 5221066..5221701 | + | 636 | WP_002882818.1 | formate dehydrogenase cytochrome b556 subunit | - |
LSG42_RS25525 (LSG42_25525) | 5221698..5222627 | + | 930 | WP_004146237.1 | formate dehydrogenase accessory protein FdhE | - |
LSG42_RS25530 (LSG42_25530) | 5222801..5223184 | - | 384 | WP_002882817.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
LSG42_RS25535 (LSG42_25535) | 5223184..5223426 | - | 243 | WP_004150355.1 | CopG family transcriptional regulator | Antitoxin |
LSG42_RS25540 (LSG42_25540) | 5223631..5224548 | + | 918 | WP_032437446.1 | alpha/beta hydrolase | - |
LSG42_RS25545 (LSG42_25545) | 5224562..5225503 | - | 942 | WP_012543287.1 | fatty acid biosynthesis protein FabY | - |
LSG42_RS25550 (LSG42_25550) | 5225548..5225985 | - | 438 | WP_002882809.1 | D-aminoacyl-tRNA deacylase | - |
LSG42_RS25555 (LSG42_25555) | 5225982..5226842 | - | 861 | WP_004146232.1 | virulence factor BrkB family protein | - |
LSG42_RS25560 (LSG42_25560) | 5226836..5227435 | - | 600 | WP_004151865.1 | glucose-1-phosphatase | - |
Associated MGEs
Loading, please wait
MGE detail | Similar MGEs | Relative position | MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
No matching records found |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 128 a.a. Molecular weight: 14377.62 Da Isoelectric Point: 7.3178
>T227647 WP_002882817.1 NZ_CP089097:c5223184-5222801 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE
Download Length: 384 bp
>T227647 NZ_CP123009:c476004-475750 [Escherichia coli O155]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9567.83 Da Isoelectric Point: 4.3509
>AT227647 WP_004150355.1 NZ_CP089097:c5223426-5223184 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW
Download Length: 243 bp
>AT227647 NZ_CP123009:c476252-476001 [Escherichia coli O155]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA
Structures
Toxin
Loading, please wait
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GPK8 |
Antitoxin
Loading, please wait
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GGU9 |