Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 5222801..5223426 Replicon chromosome
Accession NZ_CP089097
Organism Klebsiella pneumoniae strain EH13

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag LSG42_RS25530 Protein ID WP_002882817.1
Coordinates 5222801..5223184 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag LSG42_RS25535 Protein ID WP_004150355.1
Coordinates 5223184..5223426 (-) Length 81 a.a.

Genomic Context


LSG42_RS25515LSG42_RS25520LSG42_RS25525LSG42_RS25540LSG42_RS25530LSG42_RS25535LSG42_RS25545LSG42_RS25550LSG42_RS25555LSG42_RS25560
Location: 5220167..5221069 (903 bp)
Type: Others
Protein ID: WP_002882822.1
Location: 5221066..5221701 (636 bp)
Type: Others
Protein ID: WP_002882818.1
Location: 5221698..5222627 (930 bp)
Type: Others
Protein ID: WP_004146237.1
Location: 5223631..5224548 (918 bp)
Type: Others
Protein ID: WP_032437446.1
Location: 5222801..5223184 (384 bp)
Type: Toxin
Protein ID: WP_002882817.1
Location: 5223184..5223426 (243 bp)
Type: Antitoxin
Protein ID: WP_004150355.1
Location: 5224562..5225503 (942 bp)
Type: Others
Protein ID: WP_012543287.1
Location: 5225548..5225985 (438 bp)
Type: Others
Protein ID: WP_002882809.1
Location: 5225982..5226842 (861 bp)
Type: Others
Protein ID: WP_004146232.1
Location: 5226836..5227435 (600 bp)
Type: Others
Protein ID: WP_004151865.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LSG42_RS25515 (LSG42_25515)5220167..5221069+903WP_002882822.1formate dehydrogenase subunit beta-
LSG42_RS25520 (LSG42_25520)5221066..5221701+636WP_002882818.1formate dehydrogenase cytochrome b556 subunit-
LSG42_RS25525 (LSG42_25525)5221698..5222627+930WP_004146237.1formate dehydrogenase accessory protein FdhE-
LSG42_RS25530 (LSG42_25530)5222801..5223184-384WP_002882817.1type II toxin-antitoxin system VapC family toxinToxin
LSG42_RS25535 (LSG42_25535)5223184..5223426-243WP_004150355.1CopG family transcriptional regulatorAntitoxin
LSG42_RS25540 (LSG42_25540)5223631..5224548+918WP_032437446.1alpha/beta hydrolase-
LSG42_RS25545 (LSG42_25545)5224562..5225503-942WP_012543287.1fatty acid biosynthesis protein FabY-
LSG42_RS25550 (LSG42_25550)5225548..5225985-438WP_002882809.1D-aminoacyl-tRNA deacylase-
LSG42_RS25555 (LSG42_25555)5225982..5226842-861WP_004146232.1virulence factor BrkB family protein-
LSG42_RS25560 (LSG42_25560)5226836..5227435-600WP_004151865.1glucose-1-phosphatase-

Associated MGEs


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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(7-112)

Antitoxin

(16-47)


Sequences


Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T227647 WP_002882817.1 NZ_CP089097:c5223184-5222801 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

>T227647 NZ_CP123009:c476004-475750 [Escherichia coli O155]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT227647 WP_004150355.1 NZ_CP089097:c5223426-5223184 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT227647 NZ_CP123009:c476252-476001 [Escherichia coli O155]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Similar Proteins


Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures


Toxin

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Source
ID
Structure
AlphaFold DBA0A0H3GPK8


Antitoxin

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Source
ID
Structure
AlphaFold DBA0A0H3GGU9

References