Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-RelB
Location 2532996..2533519 Replicon chromosome
Accession NC_010515
Organism Burkholderia cenocepacia MC0-3

Toxin (Protein)


Gene name relE Uniprot ID B1K8I5
Locus tag BCENMC03_RS27095 Protein ID WP_012339674.1
Coordinates 2532996..2533262 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1K8I6
Locus tag BCENMC03_RS27100 Protein ID WP_011547275.1
Coordinates 2533259..2533519 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCENMC03_RS27070 2528297..2529535 - 1239 WP_012339670.1 diaminopimelate decarboxylase -
BCENMC03_RS27075 2529644..2530558 + 915 WP_011547270.1 LysR family transcriptional regulator -
BCENMC03_RS27080 2530619..2531218 + 600 WP_012339671.1 GNAT family N-acetyltransferase -
BCENMC03_RS27085 2531339..2531917 - 579 WP_012339672.1 DUF4142 domain-containing protein -
BCENMC03_RS27090 2532323..2532946 - 624 WP_006480833.1 HAD hydrolase-like protein -
BCENMC03_RS27095 2532996..2533262 - 267 WP_012339674.1 Txe/YoeB family addiction module toxin Toxin
BCENMC03_RS27100 2533259..2533519 - 261 WP_011547275.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
BCENMC03_RS27105 2533724..2534167 + 444 WP_012339675.1 GNAT family N-acetyltransferase -
BCENMC03_RS27110 2534225..2534443 + 219 WP_006480837.1 DUF1653 domain-containing protein -
BCENMC03_RS27115 2534466..2534924 - 459 WP_012339676.1 ATP synthase F1 subunit epsilon -
BCENMC03_RS27120 2534935..2535810 - 876 WP_012339677.1 ATP synthase F1 subunit gamma -
BCENMC03_RS27125 2535958..2536929 + 972 WP_006480840.1 phosphate acetyltransferase -
BCENMC03_RS27130 2536940..2538148 + 1209 WP_012339678.1 acetate/propionate family kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-72)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10530.85 Da        Isoelectric Point: 8.0229

>T22764 WP_012339674.1 NC_010515:c2533262-2532996 [Burkholderia cenocepacia MC0-3]
MSVRRVLFTSDAWDDHVYWQGQDRKTLKRINQLIRETQRTPFEGIGKPEPLKANLSGFWSRRIDDTNRLVYEADDLQLSI
VSCRYHYE

Download         Length: 267 bp

>T22764 NC_010515:c2533262-2532996 [Burkholderia cenocepacia MC0-3]
ATGAGCGTACGTCGCGTGCTCTTTACTTCCGACGCATGGGATGACCATGTCTACTGGCAAGGACAGGATCGCAAGACGCT
CAAGCGCATCAACCAGCTCATTCGCGAAACCCAGCGCACGCCGTTCGAAGGCATCGGCAAGCCGGAGCCGTTGAAAGCCA
ATCTCTCCGGCTTCTGGTCGCGCCGTATCGACGATACGAACCGCCTGGTCTACGAGGCTGACGACCTTCAACTCAGCATC
GTGTCCTGCCGCTACCATTACGAGTAG

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9745.00 Da        Isoelectric Point: 6.0717

>AT22764 WP_011547275.1 NC_010515:c2533519-2533259 [Burkholderia cenocepacia MC0-3]
MRTIHFSDARGNLKTVIDQVVDDADVTLITRRDAPNAVIMSQDYYDSLMETVHLLRSPANVAHLERSIAQLRKGKAKEHK
LAEDDE

Download         Length: 261 bp

>AT22764 NC_010515:c2533519-2533259 [Burkholderia cenocepacia MC0-3]
ATGCGCACGATTCATTTTTCGGATGCCCGCGGCAATCTGAAGACCGTCATCGACCAGGTCGTCGACGATGCGGACGTGAC
GCTCATTACGCGCCGCGATGCACCGAACGCCGTCATCATGTCGCAGGACTATTACGACAGCCTGATGGAGACGGTTCACC
TGCTGCGCTCGCCAGCCAACGTCGCTCATCTCGAACGTTCGATCGCGCAACTGCGCAAGGGCAAGGCGAAAGAACACAAG
CTCGCCGAGGATGATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B1K8I5

Antitoxin

Source ID Structure
AlphaFold DB A0A1J9NJ62

References