Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vapBC/- |
| Location | 2452793..2454019 | Replicon | chromosome |
| Accession | NC_010515 | ||
| Organism | Burkholderia cenocepacia MC0-3 | ||
Toxin (Protein)
| Gene name | vapC | Uniprot ID | B1K807 |
| Locus tag | BCENMC03_RS26725 | Protein ID | WP_011547213.1 |
| Coordinates | 2452793..2453374 (-) | Length | 194 a.a. |
Antitoxin (Protein)
| Gene name | vapB | Uniprot ID | - |
| Locus tag | BCENMC03_RS26730 | Protein ID | WP_012339628.1 |
| Coordinates | 2453453..2454019 (-) | Length | 189 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BCENMC03_RS26715 | 2449143..2451188 | - | 2046 | WP_012339627.1 | MacB family efflux pump subunit | - |
| BCENMC03_RS26720 | 2451191..2452384 | - | 1194 | WP_011547212.1 | efflux RND transporter periplasmic adaptor subunit | - |
| BCENMC03_RS26725 | 2452793..2453374 | - | 582 | WP_011547213.1 | HD domain-containing protein | Toxin |
| BCENMC03_RS26730 | 2453453..2454019 | - | 567 | WP_012339628.1 | helix-turn-helix domain-containing protein | Antitoxin |
| BCENMC03_RS26735 | 2454468..2455871 | + | 1404 | WP_012339629.1 | hypothetical protein | - |
| BCENMC03_RS26740 | 2455972..2456550 | + | 579 | WP_012339630.1 | hypothetical protein | - |
| BCENMC03_RS26745 | 2456678..2457409 | + | 732 | WP_006498851.1 | ribonuclease T2 | - |
| BCENMC03_RS26750 | 2457435..2458088 | - | 654 | WP_011547217.1 | cysteine hydrolase | - |
| BCENMC03_RS26755 | 2458334..2458954 | + | 621 | WP_041492170.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 194 a.a. Molecular weight: 21317.94 Da Isoelectric Point: 5.1207
>T22763 WP_011547213.1 NC_010515:c2453374-2452793 [Burkholderia cenocepacia MC0-3]
MNPDTIHARLAFLREAERLKDVLRSSHTSAGRPESTAEHSWRLCLMALVFTDALPGVDALKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERDDLLTLTASLDRAVRDEIVALWDEYEAAASPEARAAKALDKLETIVQHNQGSNPPDFDYAFNLGY
GRRYTDAAPLFRAIREIVDADTQRKIDAGGERA
MNPDTIHARLAFLREAERLKDVLRSSHTSAGRPESTAEHSWRLCLMALVFTDALPGVDALKLLKLCVVHDLGEALHGDIP
AIEQAAHPDKSAHERDDLLTLTASLDRAVRDEIVALWDEYEAAASPEARAAKALDKLETIVQHNQGSNPPDFDYAFNLGY
GRRYTDAAPLFRAIREIVDADTQRKIDAGGERA
Download Length: 582 bp
>T22763 NC_010515:c2453374-2452793 [Burkholderia cenocepacia MC0-3]
ATGAACCCCGATACGATCCACGCGCGACTCGCGTTCCTGCGCGAAGCCGAACGCCTGAAGGACGTGCTGCGCAGCAGCCA
CACGTCGGCCGGCCGCCCGGAAAGCACGGCCGAGCACAGCTGGCGGCTGTGCCTGATGGCGCTCGTGTTCACCGACGCAC
TGCCCGGCGTCGACGCGCTGAAGCTGCTGAAACTGTGCGTCGTCCACGACCTCGGCGAGGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGCATCCCGACAAGAGCGCACATGAACGCGACGACCTGCTGACGCTGACCGCGTCGCTAGACCG
CGCGGTGCGCGACGAGATCGTCGCGCTGTGGGACGAATACGAGGCGGCCGCCTCACCCGAAGCCCGCGCGGCGAAGGCGC
TCGACAAGCTCGAAACGATCGTGCAGCACAACCAGGGCAGCAATCCGCCCGATTTCGACTATGCGTTCAATCTCGGCTAC
GGCCGGCGCTATACCGATGCTGCGCCGCTGTTCCGCGCGATCCGCGAAATCGTCGACGCCGATACGCAGCGCAAGATCGA
CGCGGGTGGGGAGCGCGCATAG
ATGAACCCCGATACGATCCACGCGCGACTCGCGTTCCTGCGCGAAGCCGAACGCCTGAAGGACGTGCTGCGCAGCAGCCA
CACGTCGGCCGGCCGCCCGGAAAGCACGGCCGAGCACAGCTGGCGGCTGTGCCTGATGGCGCTCGTGTTCACCGACGCAC
TGCCCGGCGTCGACGCGCTGAAGCTGCTGAAACTGTGCGTCGTCCACGACCTCGGCGAGGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGCATCCCGACAAGAGCGCACATGAACGCGACGACCTGCTGACGCTGACCGCGTCGCTAGACCG
CGCGGTGCGCGACGAGATCGTCGCGCTGTGGGACGAATACGAGGCGGCCGCCTCACCCGAAGCCCGCGCGGCGAAGGCGC
TCGACAAGCTCGAAACGATCGTGCAGCACAACCAGGGCAGCAATCCGCCCGATTTCGACTATGCGTTCAATCTCGGCTAC
GGCCGGCGCTATACCGATGCTGCGCCGCTGTTCCGCGCGATCCGCGAAATCGTCGACGCCGATACGCAGCGCAAGATCGA
CGCGGGTGGGGAGCGCGCATAG
Antitoxin
Download Length: 189 a.a. Molecular weight: 20537.40 Da Isoelectric Point: 10.7076
>AT22763 WP_012339628.1 NC_010515:c2454019-2453453 [Burkholderia cenocepacia MC0-3]
MPHPPLHPSSLGPQLKRWRALHRVKQSHAAELFGVAQSTISRWEAGLQQMSPAERATAERLLAARLDSAGDHALARLIAG
SAGRMHLVCDLTHRLLASSPARAAEFSQPLSTLLGTSLWRYATPEIVRMEAALDPFGWHDRAGPPSVEFDTGANASRVAP
IRGSRCRWTRMTLSDSSAVRLVETLDAH
MPHPPLHPSSLGPQLKRWRALHRVKQSHAAELFGVAQSTISRWEAGLQQMSPAERATAERLLAARLDSAGDHALARLIAG
SAGRMHLVCDLTHRLLASSPARAAEFSQPLSTLLGTSLWRYATPEIVRMEAALDPFGWHDRAGPPSVEFDTGANASRVAP
IRGSRCRWTRMTLSDSSAVRLVETLDAH
Download Length: 567 bp
>AT22763 NC_010515:c2454019-2453453 [Burkholderia cenocepacia MC0-3]
ATGCCCCATCCGCCGCTTCATCCATCCTCGCTCGGCCCGCAACTCAAGCGCTGGCGCGCGCTGCACCGCGTGAAGCAAAG
CCATGCAGCCGAACTGTTCGGCGTCGCGCAATCGACGATCTCGCGCTGGGAAGCCGGCCTCCAGCAGATGTCGCCCGCCG
AGCGCGCGACGGCCGAACGGCTGCTCGCGGCGCGCCTCGACTCGGCGGGCGACCACGCACTCGCGCGGCTGATCGCCGGC
AGCGCGGGCCGCATGCATCTCGTGTGCGACCTCACGCACCGCCTGCTGGCCAGTTCCCCAGCACGCGCGGCCGAGTTCTC
GCAACCGCTTTCGACGTTGCTCGGCACGTCGCTGTGGCGCTACGCGACACCGGAGATCGTCCGCATGGAAGCCGCGCTCG
ACCCGTTCGGCTGGCACGACCGCGCGGGGCCGCCGAGCGTCGAGTTCGACACCGGCGCGAATGCGTCGCGCGTCGCGCCG
ATTCGCGGCAGCCGATGCCGGTGGACACGGATGACACTGTCGGACAGCTCGGCCGTGCGGCTCGTGGAGACGCTCGACGC
ACACTGA
ATGCCCCATCCGCCGCTTCATCCATCCTCGCTCGGCCCGCAACTCAAGCGCTGGCGCGCGCTGCACCGCGTGAAGCAAAG
CCATGCAGCCGAACTGTTCGGCGTCGCGCAATCGACGATCTCGCGCTGGGAAGCCGGCCTCCAGCAGATGTCGCCCGCCG
AGCGCGCGACGGCCGAACGGCTGCTCGCGGCGCGCCTCGACTCGGCGGGCGACCACGCACTCGCGCGGCTGATCGCCGGC
AGCGCGGGCCGCATGCATCTCGTGTGCGACCTCACGCACCGCCTGCTGGCCAGTTCCCCAGCACGCGCGGCCGAGTTCTC
GCAACCGCTTTCGACGTTGCTCGGCACGTCGCTGTGGCGCTACGCGACACCGGAGATCGTCCGCATGGAAGCCGCGCTCG
ACCCGTTCGGCTGGCACGACCGCGCGGGGCCGCCGAGCGTCGAGTTCGACACCGGCGCGAATGCGTCGCGCGTCGCGCCG
ATTCGCGGCAGCCGATGCCGGTGGACACGGATGACACTGTCGGACAGCTCGGCCGTGCGGCTCGTGGAGACGCTCGACGC
ACACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|