Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type VII Classification (family/domain) HepT-MntA/HepT(toxin)
Location 859104..859963 Replicon chromosome
Accession NZ_CP089094
Organism Microcystis aeruginosa FACHB-905 = DIANCHI905

Toxin (Protein)


Gene name hepT Uniprot ID A0A1X9LDD0
Locus tag LRR78_RS04140 Protein ID WP_002742889.1
Coordinates 859565..859963 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name mntA Uniprot ID A0A1X9LBQ1
Locus tag LRR78_RS04135 Protein ID WP_002742890.1
Coordinates 859104..859523 (+) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LRR78_RS04115 (LRR78_04115) 854832..855695 - 864 WP_002742899.1 WYL domain-containing protein -
LRR78_RS04120 (LRR78_04120) 855794..857959 + 2166 WP_084990033.1 type I-D CRISPR-associated helicase Cas3' -
LRR78_RS04125 (LRR78_04125) 858006..858248 + 243 WP_002742893.1 hypothetical protein -
LRR78_RS04130 (LRR78_04130) 858594..858941 + 348 WP_002742891.1 hypothetical protein -
LRR78_RS04135 (LRR78_04135) 859104..859523 + 420 WP_002742890.1 nucleotidyltransferase domain-containing protein Antitoxin
LRR78_RS04140 (LRR78_04140) 859565..859963 + 399 WP_002742889.1 DUF86 domain-containing protein Toxin
LRR78_RS04145 (LRR78_04145) 859956..860414 + 459 WP_036400372.1 nucleotidyltransferase domain-containing protein -
LRR78_RS04150 (LRR78_04150) 860500..860643 + 144 WP_002742887.1 hypothetical protein -
LRR78_RS04155 (LRR78_04155) 860636..864082 + 3447 WP_002742886.1 type I-D CRISPR-associated protein Cas10d/Csc3 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease HepT-like

(1-117)

Antitoxin

Polymerase beta, nucleotidyltransferase

(6-101)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15324.59 Da        Isoelectric Point: 4.6345

>T227625 WP_002742889.1 NZ_CP089094:859565-859963 [Microcystis aeruginosa FACHB-905 = DIANCHI905]
MNQYLAELSEYGSITLEDYRTLRERQLAIERLIQLIIQTGIDINYQILKCLDIESPNNARDALFQIVELGILEEHLAVQL
AESIKLRNLLVHLYKKIDPDIVHSSIANILRDYPRYQRSIVQFLDSLEAENG

Download         Length: 399 bp

>T227625 NZ_CP123008:c476204-475953 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 16307.78 Da        Isoelectric Point: 5.1063

>AT227625 WP_002742890.1 NZ_CP089094:859104-859523 [Microcystis aeruginosa FACHB-905 = DIANCHI905]
MNRLVEKITAIVEKLPNLKLLILFGSRARREHRPDSDWDFAVLYEERSDQKDISSLLKIYTLLEQALEIPEDKIDVVDLK
ECSPILAHYVARDGQLLYERETGLFEGFKEKFLMNPEESKALYRQLRNNLEISLREKGV

Download         Length: 420 bp

>AT227625 NZ_CP123008:c475956-475702 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X9LDD0

Antitoxin

Source ID Structure
AlphaFold DB A0A1X9LBQ1

References