Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1982351..1982916 Replicon chromosome
Accession NC_010515
Organism Burkholderia cenocepacia MC0-3

Toxin (Protein)


Gene name vapC Uniprot ID B1K5P4
Locus tag BCENMC03_RS24835 Protein ID WP_012339368.1
Coordinates 1982351..1982722 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID B1FGI9
Locus tag BCENMC03_RS24840 Protein ID WP_006752328.1
Coordinates 1982719..1982916 (-) Length 66 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BCENMC03_RS24820 1978212..1978937 + 726 WP_012339365.1 site-2 protease family protein -
BCENMC03_RS24825 1979004..1980398 - 1395 WP_041492169.1 MFS transporter -
BCENMC03_RS24830 1980646..1982223 + 1578 WP_012339367.1 aldehyde dehydrogenase (NADP(+)) -
BCENMC03_RS24835 1982351..1982722 - 372 WP_012339368.1 PIN domain-containing protein Toxin
BCENMC03_RS24840 1982719..1982916 - 198 WP_006752328.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
BCENMC03_RS24845 1983102..1983656 + 555 WP_006480480.1 hypothetical protein -
BCENMC03_RS24850 1983771..1984685 - 915 WP_011546881.1 5-dehydro-4-deoxyglucarate dehydratase -
BCENMC03_RS24855 1984915..1986468 + 1554 WP_012339369.1 galactarate dehydratase -
BCENMC03_RS24860 1986554..1987036 - 483 WP_011546883.1 Lrp/AsnC family transcriptional regulator -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-112)

Antitoxin

(1-46)


Sequences


Toxin        


Download         Length: 124 a.a.        Molecular weight: 13522.61 Da        Isoelectric Point: 5.9735

>T22762 WP_012339368.1 NC_010515:c1982722-1982351 [Burkholderia cenocepacia MC0-3]
MILVDTSVWIDHLRGGDATLTALLEAERVLIHPFIVGELALGSMRNRETVLDALRDLPAATLATDDEVQRMIDAVPLHGL
GIGYVDAHLLASARLTSDSRLWTRDRRLLAAAERLQLVARPAH

Download         Length: 372 bp

>T22762 NC_010515:c1982722-1982351 [Burkholderia cenocepacia MC0-3]
ATGATCCTTGTCGACACGTCCGTCTGGATCGATCACTTGCGAGGCGGCGACGCCACGCTCACCGCCTTGCTGGAAGCGGA
GCGCGTATTGATCCATCCGTTCATCGTCGGCGAGCTTGCGCTCGGCAGCATGCGCAATCGCGAGACCGTGCTGGATGCGC
TGCGCGACCTTCCAGCTGCAACCCTTGCCACCGACGACGAAGTCCAGCGCATGATCGATGCCGTACCGCTTCACGGGCTG
GGCATCGGCTACGTCGATGCCCACCTGCTTGCGTCGGCCAGACTGACCAGCGACAGCAGGCTATGGACGCGCGACCGGCG
CCTGCTGGCGGCAGCGGAGCGCCTGCAACTCGTCGCCCGCCCCGCTCACTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7054.10 Da        Isoelectric Point: 10.6826

>AT22762 WP_006752328.1 NC_010515:c1982916-1982719 [Burkholderia cenocepacia MC0-3]
MRTTLSLDDALLAKAQQLTGVTEKSALVREALRALIARESARRLARLGGTEPDLESVPRRPSEPA

Download         Length: 198 bp

>AT22762 NC_010515:c1982916-1982719 [Burkholderia cenocepacia MC0-3]
ATGCGCACCACCTTGTCCCTCGACGACGCACTGCTCGCCAAAGCGCAGCAATTGACCGGCGTCACCGAAAAATCGGCGCT
CGTGAGGGAAGCGCTGCGCGCATTGATCGCCCGCGAAAGTGCGCGACGACTCGCCCGCCTCGGCGGCACCGAGCCCGACC
TCGAATCGGTTCCACGTCGCCCGTCGGAGCCCGCATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB B1K5P4


Antitoxin

Source ID Structure
AlphaFold DB A0A2S9KMB8

References