Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | vapBC/VapC-VapB |
Location | 1982351..1982916 | Replicon | chromosome |
Accession | NC_010515 | ||
Organism | Burkholderia cenocepacia MC0-3 |
Toxin (Protein)
Gene name | vapC | Uniprot ID | B1K5P4 |
Locus tag | BCENMC03_RS24835 | Protein ID | WP_012339368.1 |
Coordinates | 1982351..1982722 (-) | Length | 124 a.a. |
Antitoxin (Protein)
Gene name | vapB | Uniprot ID | B1FGI9 |
Locus tag | BCENMC03_RS24840 | Protein ID | WP_006752328.1 |
Coordinates | 1982719..1982916 (-) | Length | 66 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
BCENMC03_RS24820 | 1978212..1978937 | + | 726 | WP_012339365.1 | site-2 protease family protein | - |
BCENMC03_RS24825 | 1979004..1980398 | - | 1395 | WP_041492169.1 | MFS transporter | - |
BCENMC03_RS24830 | 1980646..1982223 | + | 1578 | WP_012339367.1 | aldehyde dehydrogenase (NADP(+)) | - |
BCENMC03_RS24835 | 1982351..1982722 | - | 372 | WP_012339368.1 | PIN domain-containing protein | Toxin |
BCENMC03_RS24840 | 1982719..1982916 | - | 198 | WP_006752328.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
BCENMC03_RS24845 | 1983102..1983656 | + | 555 | WP_006480480.1 | hypothetical protein | - |
BCENMC03_RS24850 | 1983771..1984685 | - | 915 | WP_011546881.1 | 5-dehydro-4-deoxyglucarate dehydratase | - |
BCENMC03_RS24855 | 1984915..1986468 | + | 1554 | WP_012339369.1 | galactarate dehydratase | - |
BCENMC03_RS24860 | 1986554..1987036 | - | 483 | WP_011546883.1 | Lrp/AsnC family transcriptional regulator | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 124 a.a. Molecular weight: 13522.61 Da Isoelectric Point: 5.9735
>T22762 WP_012339368.1 NC_010515:c1982722-1982351 [Burkholderia cenocepacia MC0-3]
MILVDTSVWIDHLRGGDATLTALLEAERVLIHPFIVGELALGSMRNRETVLDALRDLPAATLATDDEVQRMIDAVPLHGL
GIGYVDAHLLASARLTSDSRLWTRDRRLLAAAERLQLVARPAH
MILVDTSVWIDHLRGGDATLTALLEAERVLIHPFIVGELALGSMRNRETVLDALRDLPAATLATDDEVQRMIDAVPLHGL
GIGYVDAHLLASARLTSDSRLWTRDRRLLAAAERLQLVARPAH
Download Length: 372 bp
>T22762 NC_010515:c1982722-1982351 [Burkholderia cenocepacia MC0-3]
ATGATCCTTGTCGACACGTCCGTCTGGATCGATCACTTGCGAGGCGGCGACGCCACGCTCACCGCCTTGCTGGAAGCGGA
GCGCGTATTGATCCATCCGTTCATCGTCGGCGAGCTTGCGCTCGGCAGCATGCGCAATCGCGAGACCGTGCTGGATGCGC
TGCGCGACCTTCCAGCTGCAACCCTTGCCACCGACGACGAAGTCCAGCGCATGATCGATGCCGTACCGCTTCACGGGCTG
GGCATCGGCTACGTCGATGCCCACCTGCTTGCGTCGGCCAGACTGACCAGCGACAGCAGGCTATGGACGCGCGACCGGCG
CCTGCTGGCGGCAGCGGAGCGCCTGCAACTCGTCGCCCGCCCCGCTCACTGA
ATGATCCTTGTCGACACGTCCGTCTGGATCGATCACTTGCGAGGCGGCGACGCCACGCTCACCGCCTTGCTGGAAGCGGA
GCGCGTATTGATCCATCCGTTCATCGTCGGCGAGCTTGCGCTCGGCAGCATGCGCAATCGCGAGACCGTGCTGGATGCGC
TGCGCGACCTTCCAGCTGCAACCCTTGCCACCGACGACGAAGTCCAGCGCATGATCGATGCCGTACCGCTTCACGGGCTG
GGCATCGGCTACGTCGATGCCCACCTGCTTGCGTCGGCCAGACTGACCAGCGACAGCAGGCTATGGACGCGCGACCGGCG
CCTGCTGGCGGCAGCGGAGCGCCTGCAACTCGTCGCCCGCCCCGCTCACTGA
Antitoxin
Download Length: 66 a.a. Molecular weight: 7054.10 Da Isoelectric Point: 10.6826
>AT22762 WP_006752328.1 NC_010515:c1982916-1982719 [Burkholderia cenocepacia MC0-3]
MRTTLSLDDALLAKAQQLTGVTEKSALVREALRALIARESARRLARLGGTEPDLESVPRRPSEPA
MRTTLSLDDALLAKAQQLTGVTEKSALVREALRALIARESARRLARLGGTEPDLESVPRRPSEPA
Download Length: 198 bp
>AT22762 NC_010515:c1982916-1982719 [Burkholderia cenocepacia MC0-3]
ATGCGCACCACCTTGTCCCTCGACGACGCACTGCTCGCCAAAGCGCAGCAATTGACCGGCGTCACCGAAAAATCGGCGCT
CGTGAGGGAAGCGCTGCGCGCATTGATCGCCCGCGAAAGTGCGCGACGACTCGCCCGCCTCGGCGGCACCGAGCCCGACC
TCGAATCGGTTCCACGTCGCCCGTCGGAGCCCGCATGA
ATGCGCACCACCTTGTCCCTCGACGACGCACTGCTCGCCAAAGCGCAGCAATTGACCGGCGTCACCGAAAAATCGGCGCT
CGTGAGGGAAGCGCTGCGCGCATTGATCGCCCGCGAAAGTGCGCGACGACTCGCCCGCCTCGGCGGCACCGAGCCCGACC
TCGAATCGGTTCCACGTCGCCCGTCGGAGCCCGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | B1K5P4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2S9KMB8 |