227615

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 5034328..5035549 Replicon chromosome
Accession NZ_CP089068
Organism Pseudomonas aeruginosa strain UNC_PaerCF13

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LSP21_RS22975 Protein ID WP_003160088.1
Coordinates 5034971..5035549 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LSP21_RS22970 Protein ID WP_003088112.1
Coordinates 5034328..5034882 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSP21_RS22945 (LSP21_22955) 5029896..5030447 + 552 WP_003132721.1 XRE family transcriptional regulator -
LSP21_RS22950 (LSP21_22960) 5030444..5030842 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
LSP21_RS22955 (LSP21_22965) 5030855..5031178 - 324 WP_003102734.1 multidrug efflux SMR transporter -
LSP21_RS22960 (LSP21_22970) 5031509..5031970 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
LSP21_RS22965 (LSP21_22975) 5031975..5034170 + 2196 WP_004349295.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
LSP21_RS22970 (LSP21_22980) 5034328..5034882 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
LSP21_RS22975 (LSP21_22985) 5034971..5035549 + 579 WP_003160088.1 HD domain-containing protein Toxin
LSP21_RS22980 (LSP21_22990) 5035658..5036845 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
LSP21_RS22985 (LSP21_22995) 5036835..5039006 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
LSP21_RS22990 (LSP21_23000) 5038996..5040273 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21816.65 Da        Isoelectric Point: 5.1625

>T227615 WP_003160088.1 NZ_CP089068:5034971-5035549 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA

Download         Length: 579 bp

>T227615 NZ_CP123005:c1021320-1021147 [Sinorhizobium meliloti]
ATGAAGCTCGTCTGGGCGCGATATGCGCTTGACGATCGCGACGCCATCTTCAGCTACATCGAACGAGAGAATCCGAGGGC
GGCGGTCCACGTTGACGAGGAGGTCGTCAGCGCTGGTCGTCCGCTGGACTTTCCCGAAAGCCGCCGCCCTGGCCGGATTG
CCGGAACTCCATGA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT227615 WP_003088112.1 NZ_CP089068:5034328-5034882 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT227615 NZ_CP123005:c1021646-1021317 [Sinorhizobium meliloti]
GTGAGCGAGCGCCTTCTGCTCATCGCCCTCCTGGCCCTCGGTCCGTTCCGAGCCAGCCAGCGGCATACCGGTCGTCCTGC
TCTGCTACGGCGTGGCCCCCAAACGGCCGCCGGCGCGGTCGAGGAGCACTTCATCCAACTCCGCGCTCCGCTGTGGCTGA
TCACGCTCGGCGGTTTCAGCCACAGAGAGGCTCACGACGCTTGGTTCCGCGCCAAAGTTTTGCGGGCACTCGAGGACACT
CGACCCGATGCGGACGACGCCGACGCCGATGCGCACTTTCAAGAGCGCCGCGCCGCAGCTTTGCGCAAGGCTGCGGCGGG
TGATCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References