Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/HTH_IclR(antitoxin) |
| Location | 3098700..3100395 | Replicon | chromosome |
| Accession | NZ_CP089068 | ||
| Organism | Pseudomonas aeruginosa strain UNC_PaerCF13 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | Q9HYA0 |
| Locus tag | LSP21_RS14300 | Protein ID | WP_003112901.1 |
| Coordinates | 3098700..3099569 (+) | Length | 290 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | A0A1C7C9F9 |
| Locus tag | LSP21_RS14305 | Protein ID | WP_017001846.1 |
| Coordinates | 3099562..3100395 (+) | Length | 278 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LSP21_RS14275 (LSP21_14280) | 3094708..3095559 | + | 852 | WP_003130104.1 | ABC transporter ATP-binding protein | - |
| LSP21_RS14280 (LSP21_14285) | 3095600..3096607 | + | 1008 | WP_003162724.1 | ABC transporter substrate-binding protein | - |
| LSP21_RS14285 (LSP21_14290) | 3096604..3097380 | + | 777 | WP_003112898.1 | ABC transporter permease | - |
| LSP21_RS14290 (LSP21_14295) | 3097386..3098147 | + | 762 | WP_017001847.1 | SDR family oxidoreductase | - |
| LSP21_RS14295 (LSP21_14300) | 3098161..3098691 | + | 531 | WP_003112900.1 | cupin domain-containing protein | - |
| LSP21_RS14300 (LSP21_14305) | 3098700..3099569 | + | 870 | WP_003112901.1 | alpha/beta hydrolase | Toxin |
| LSP21_RS14305 (LSP21_14310) | 3099562..3100395 | + | 834 | WP_017001846.1 | IclR family transcriptional regulator | Antitoxin |
| LSP21_RS14310 (LSP21_14315) | 3100382..3101179 | + | 798 | WP_017001845.1 | SDR family oxidoreductase | - |
| LSP21_RS14315 (LSP21_14320) | 3101172..3102854 | + | 1683 | WP_017001844.1 | thiamine pyrophosphate-binding protein | - |
| LSP21_RS14320 (LSP21_14325) | 3102865..3103668 | + | 804 | WP_003453564.1 | aspartate dehydrogenase | - |
| LSP21_RS14325 (LSP21_14330) | 3103680..3105164 | + | 1485 | WP_231800173.1 | aldehyde dehydrogenase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 290 a.a. Molecular weight: 30403.60 Da Isoelectric Point: 6.5894
>T227613 WP_003112901.1 NZ_CP089068:3098700-3099569 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG
Download Length: 870 bp
>T227613 NZ_CP123004:c199082-198807 [Sinorhizobium meliloti]
ATGAAGCTTGAGTGGACGAGTAAGGCAGTCGCCGATCTTGGGCGCCTCTATGATTTCCTGGCATCGGTAAATCGGCAAGC
TGCGGCTCGTACTGTGCAATCGTTGACGAGCGCTCCAGCACGCCTGCTCGAACAACCGCGTATCGGCGAACGGCTGGAGG
AATTCGACCCTCGAGAGGTTCGGCGAATTCTCATTGGCCATTACGAAATACGGTATGAGATCCGGCAGTCGACGATCTAC
GTGCTGCGGCTTTGGCATACGCGTGAAGAGCGGTAG
ATGAAGCTTGAGTGGACGAGTAAGGCAGTCGCCGATCTTGGGCGCCTCTATGATTTCCTGGCATCGGTAAATCGGCAAGC
TGCGGCTCGTACTGTGCAATCGTTGACGAGCGCTCCAGCACGCCTGCTCGAACAACCGCGTATCGGCGAACGGCTGGAGG
AATTCGACCCTCGAGAGGTTCGGCGAATTCTCATTGGCCATTACGAAATACGGTATGAGATCCGGCAGTCGACGATCTAC
GTGCTGCGGCTTTGGCATACGCGTGAAGAGCGGTAG
Antitoxin
Download Length: 278 a.a. Molecular weight: 30867.22 Da Isoelectric Point: 5.7725
>AT227613 WP_017001846.1 NZ_CP089068:3099562-3100395 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRSHETV
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRSHETV
Download Length: 834 bp
>AT227613 NZ_CP123004:c199342-199082 [Sinorhizobium meliloti]
ATGGAAACCAAGGTGCTGACCGCGCACGTGCCACTGCCGCTCGCCGAGAAAGTCGATCAGATCGCGGCCCGGCTTGAGCG
CTCGCGCGGGTGGATCGTCAAGCAGGCGCTGACCGCCTGGGTCGATCAGGAAGAGGAGCGCCGACGCTTGACGCTGGAAG
CGCTTGCCGACGTCGACGCTGGCCGCGTTATCGATCACCAGGCCGTCCAGGCCTGGGCCGACAGTCTTGATAGTGACAAG
CCGCTATCCTTGCCGCTGTGA
ATGGAAACCAAGGTGCTGACCGCGCACGTGCCACTGCCGCTCGCCGAGAAAGTCGATCAGATCGCGGCCCGGCTTGAGCG
CTCGCGCGGGTGGATCGTCAAGCAGGCGCTGACCGCCTGGGTCGATCAGGAAGAGGAGCGCCGACGCTTGACGCTGGAAG
CGCTTGCCGACGTCGACGCTGGCCGCGTTATCGATCACCAGGCCGTCCAGGCCTGGGCCGACAGTCTTGATAGTGACAAG
CCGCTATCCTTGCCGCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | Q9HYA0 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1C7C9F9 |