227608

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 5203254..5203770 Replicon chromosome
Accession NZ_CP089067
Organism Pseudomonas aeruginosa strain UNC_PaerCF19

Toxin (Protein)


Gene name relE Uniprot ID A0A3R8UIH5
Locus tag LSP16_RS24390 Protein ID WP_025297453.1
Coordinates 5203254..5203535 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3R8UIM7
Locus tag LSP16_RS24395 Protein ID WP_025297454.1
Coordinates 5203525..5203770 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSP16_RS24370 (LSP16_24260) 5198997..5199644 - 648 WP_033976844.1 peptidase M15 -
LSP16_RS24375 (LSP16_24265) 5199668..5201248 - 1581 WP_070147860.1 DNA recombination protein RmuC -
LSP16_RS24380 (LSP16_24270) 5201378..5202253 + 876 WP_033976847.1 WYL domain-containing protein -
LSP16_RS24385 (LSP16_24275) 5202267..5202848 + 582 WP_033976848.1 plasmid pRiA4b ORF-3 family protein -
LSP16_RS24390 (LSP16_24280) 5203254..5203535 - 282 WP_025297453.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LSP16_RS24395 (LSP16_24285) 5203525..5203770 - 246 WP_025297454.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LSP16_RS24400 (LSP16_24290) 5204205..5204459 + 255 WP_153574174.1 hypothetical protein -
LSP16_RS24405 (LSP16_24295) 5204617..5205693 + 1077 WP_052156709.1 WYL domain-containing protein -
LSP16_RS24410 (LSP16_24300) 5205791..5207992 + 2202 WP_033976850.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 5172085..5224768 52683


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(10-71)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10824.61 Da        Isoelectric Point: 10.6249

>T227608 WP_025297453.1 NZ_CP089067:c5203535-5203254 [Pseudomonas aeruginosa]
MTYELEFLPSALKEWQKLGHTVREQIKKKLRERLDNPKVQADALRDMPGHYKIKLRASGYRLVYRVEDERVVVVVVAVGK
RERGAAYQSAKGR

Download         Length: 282 bp

>T227608 NZ_CP123003:2299205-2299393 [Sinorhizobium meliloti]
ATGAAGAGCGGCGACATTATTGCAGCATTGCAGAAGGACGGATGGTACGAGGTTGCGACCAAGGGCAGCCACGTTCAATT
CAAACATCCGAAAAAGCACGGCCGGGTTACCGTTCCTCACCCGAAGAGGGATCTACCAATCGGTACCCTCAGGAGCATTG
AAAAGCAGTCCGGTTTGAAATTGAGGTAA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8797.21 Da        Isoelectric Point: 4.2550

>AT227608 WP_025297454.1 NZ_CP089067:c5203770-5203525 [Pseudomonas aeruginosa]
MQSILADVAVSVSELKKNPSGILAGAGGMPVAVLNHNRVMGYMVPAELYEQMMERLDDLELVEIVKARSGEESVPVRLDD
L

Download         Length: 246 bp

>AT227608 NZ_CP123003:2299398-2299859 [Sinorhizobium meliloti]
ATGCGCAACTATATCGGATTGATCCACAAGGACGCCGAGAGCGATTACGGCGTTTCCTTTCCTGATTTTTCCGGCGTCGT
GACCGCCGGTGCCGACCTCGACGACGCGCGCGCTATGGCAGAGGAAGCCTTGGCCTTGCATATTGAAGGGCTGGTAGAGG
ACGGCGAGGCCATCCCGGAGCCCTCCTCCCTTGAGGTTGTCATGTCCGACGCCGAGAACAGGGATTGCGTCGCTATTCTC
GTCGCGGTGAAAACCGAGGCAAAAAGAGCCATTCGAGTGAACGTTACGCTTCCCGAAGGTGTCCTGAAGCAGATAGATGC
CTTCGCCGAAGCCCACGGCCTTACGCGGTCTGGATTTCTTGCTCGTGCTGCAACGCACGAGATCGAACGGGCAAATGACG
GCCACGACGCCTATGCGGAATCCCGCTTGTCGGCTTTGGGCACTTCCAGCAAAAATGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3R8UIH5

Antitoxin

Source ID Structure
AlphaFold DB A0A3R8UIM7

References