Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3989641..3990862 Replicon chromosome
Accession NZ_CP089067
Organism Pseudomonas aeruginosa strain UNC_PaerCF19

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LSP16_RS19040 Protein ID WP_003114949.1
Coordinates 3989641..3990219 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LSP16_RS19045 Protein ID WP_003088112.1
Coordinates 3990308..3990862 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSP16_RS19025 (LSP16_19040) 3984917..3986194 + 1278 WP_003102743.1 TolC family protein -
LSP16_RS19030 (LSP16_19045) 3986184..3988355 + 2172 WP_003114950.1 type I secretion system permease/ATPase -
LSP16_RS19035 (LSP16_19050) 3988345..3989532 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
LSP16_RS19040 (LSP16_19055) 3989641..3990219 - 579 WP_003114949.1 HD domain-containing protein Toxin
LSP16_RS19045 (LSP16_19060) 3990308..3990862 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
LSP16_RS19050 (LSP16_19065) 3991020..3993215 - 2196 WP_219832416.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
LSP16_RS19055 (LSP16_19070) 3993220..3993681 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
LSP16_RS19060 (LSP16_19075) 3994012..3994335 + 324 WP_003102734.1 multidrug efflux SMR transporter -
LSP16_RS19065 (LSP16_19080) 3994348..3994746 + 399 WP_003117664.1 NADH-quinone oxidoreductase subunit A -
LSP16_RS19070 (LSP16_19085) 3994743..3995294 - 552 WP_003102727.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T227607 WP_003114949.1 NZ_CP089067:c3990219-3989641 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T227607 NZ_CP123003:c1437490-1437125 [Sinorhizobium meliloti]
ATGGTAGGCGCACTGTTCGATACCAATATCCTTATCGATCATCTGAATGCGGTGCCTCAGGCGCACAAGGAACTTGACCG
TTTCGAAAACCGGGCCATCAGCATCATCACCTGGATGGAGGTGATGGTTGGAGCGGACGCCGAACTGGTTGAGCCGACCC
GGCGCTTCCTCGACGGTTTCGAAACGATCGCCTTGAACGATGAGATCGCCAACCGTGCGGTGACATTGCGCAGGGCGCAC
CGCATCAAGCTACCCGACGCGGTGATCTGGGCAACGGCGCAGACTGCCGGTCGTCTGCTCGTGACGCGCAATACCAAGGA
CTTTCCAGCCGACGACCCGGGGATACGCGAACCCTACGCCGTGTAG

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT227607 WP_003088112.1 NZ_CP089067:c3990862-3990308 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT227607 NZ_CP123003:c1437699-1437484 [Sinorhizobium meliloti]
ATGCGAGCCTTGATCGATATGAACGATACCCAGGTCGAAGCCCTAGATACCCTCGCCAAGCGGGTGCGCCGGTCCCGTGC
GGCTCTGATCCGCGAAGCGATCGACGACTATCTCAACCGTCATCATCGCGAGCAGATCGAAGATGGCTTCGGTTTGTGGG
GCAAGCGCAAAGTTGACGGTCTGGCTTATCAGGAGAAGGTGCGCGGCGAATGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References