Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 2839216..2839873 Replicon chromosome
Accession NZ_CP089067
Organism Pseudomonas aeruginosa strain UNC_PaerCF19

Toxin (Protein)


Gene name hicA Uniprot ID A0A8G3IXE4
Locus tag LSP16_RS13535 Protein ID WP_003098540.1
Coordinates 2839691..2839873 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag LSP16_RS13530 Protein ID WP_004351284.1
Coordinates 2839216..2839644 (-) Length 143 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSP16_RS13500 (LSP16_13490) 2834416..2834772 + 357 WP_019486509.1 hypothetical protein -
LSP16_RS32355 2834776..2834910 + 135 WP_019486508.1 hypothetical protein -
LSP16_RS13505 (LSP16_13495) 2834907..2835221 + 315 WP_033939392.1 hypothetical protein -
LSP16_RS13510 (LSP16_13500) 2835221..2836279 + 1059 WP_175597968.1 hypothetical protein -
LSP16_RS13515 (LSP16_13505) 2836273..2838084 + 1812 WP_052169003.1 DnaB-like helicase C-terminal domain-containing protein -
LSP16_RS13520 (LSP16_13510) 2838081..2838344 + 264 Protein_2663 hypothetical protein -
LSP16_RS13525 (LSP16_13515) 2838360..2838917 + 558 WP_015980945.1 hypothetical protein -
LSP16_RS13530 (LSP16_13520) 2839216..2839644 - 429 WP_004351284.1 hypothetical protein Antitoxin
LSP16_RS13535 (LSP16_13525) 2839691..2839873 - 183 WP_003098540.1 type II toxin-antitoxin system HicA family toxin Toxin
LSP16_RS13540 (LSP16_13530) 2840074..2840388 + 315 WP_015649339.1 phage holin, lambda family -
LSP16_RS13545 (LSP16_13535) 2840388..2841005 + 618 WP_012613700.1 glycoside hydrolase family 19 protein -
LSP16_RS13550 (LSP16_13540) 2841026..2841478 + 453 WP_238162345.1 lysis system i-spanin subunit Rz -
LSP16_RS13555 (LSP16_13545) 2841478..2841807 + 330 WP_033939384.1 HNH endonuclease signature motif containing protein -
LSP16_RS13560 (LSP16_13550) 2841924..2842415 + 492 WP_049305509.1 terminase small subunit -
LSP16_RS13565 (LSP16_13555) 2842419..2844098 + 1680 WP_108116117.1 terminase large subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2796803..2863216 66413


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(7-78)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6746.86 Da        Isoelectric Point: 11.0775

>T227605 WP_003098540.1 NZ_CP089067:c2839873-2839691 [Pseudomonas aeruginosa]
MKFSEFRRWLKAQGVTFEAGKGSHFKITAPNGKQTTFADHGAKEMPEPTRKAIIKQLGLK

Download         Length: 183 bp

>T227605 NZ_CP123003:c871411-871025 [Sinorhizobium meliloti]
ATGGTCATCGACACATCCGCCATTGCCGCGATTGCCTTCAATGAACAGGAGGCCGGAAGTTTCCGCGAAAAAATCGCGGA
CGACCCGGTTCGGCTCATCTCCGCGGCAACCGCTCTGGAAGCGGCCATGGTAATCGAAACCCGGTTAGGCGAAGCTGCCG
GAGCGGAACTTGATCTTTGGCTTTACAAGGCAAACGTGGAGATTGTTGCGGTAACCGCCGAGCATATGGACCAGGCCCGC
CGTGCCTGGCGCCGTTTCGGCAAAGGCCGTCATCCGGCCGGTTTGAATTTCGGTGATTGTTTTTCCTATGCCCTGGCCTT
TCTGACAAATGAACCGCTTCTCTTCAAGGGAAGCGATTTCTCGCAAACCGATATCCCGGCGGCATAA

Antitoxin


Download         Length: 143 a.a.        Molecular weight: 15756.94 Da        Isoelectric Point: 4.6562

>AT227605 WP_004351284.1 NZ_CP089067:c2839644-2839216 [Pseudomonas aeruginosa]
MYDYAIRFEQDDSAPGVAVFCRDLPELNSYGDDKVHAIGEAVDAIESTLSLYVDQRREIPAASQAQPGERVIHLPAVTVA
KIALWNEMVRRDMRKADLCRLLGIAQTQGDRLVDFLHNTKMEAMENALSALGLRLSVNIEAA

Download         Length: 429 bp

>AT227605 NZ_CP123003:c871665-871411 [Sinorhizobium meliloti]
ATGGCGCTGAGCATCAAGGACACTGAAACCGAGCAGCTTGCCCGCACACTTGCCCGGCGGACAGGGGAATCCATCACGCT
TGCCACCAAGCGTGCCCTCGAAGAACGATTGCGCCGAACCGACACCGCTGCCCGGCGCGCGGCTCTTCTGGAGGATCTGG
AAGCCATTCAACGCCGCTGGAATGCCATGCCCGTCCTCGACAGTCGCAGCTCCGATGACATTATCGGTTATGACGAGGAT
GGACTCCCCTCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References