Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2326455..2327095 Replicon chromosome
Accession NZ_CP089067
Organism Pseudomonas aeruginosa strain UNC_PaerCF19

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LSP16_RS11040 Protein ID WP_033993319.1
Coordinates 2326685..2327095 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LSP16_RS11035 Protein ID WP_031634724.1
Coordinates 2326455..2326685 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSP16_RS11025 (LSP16_11015) 2323457..2324209 - 753 WP_121372664.1 hypothetical protein -
LSP16_RS11030 (LSP16_11020) 2324218..2326137 - 1920 WP_121372663.1 type I DNA topoisomerase -
LSP16_RS11035 (LSP16_11025) 2326455..2326685 + 231 WP_031634724.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
LSP16_RS11040 (LSP16_11030) 2326685..2327095 + 411 WP_033993319.1 tRNA(fMet)-specific endonuclease VapC Toxin
LSP16_RS11045 (LSP16_11035) 2327111..2327308 + 198 WP_003123325.1 hypothetical protein -
LSP16_RS11050 (LSP16_11040) 2327322..2327540 + 219 WP_121372662.1 hypothetical protein -
LSP16_RS11055 (LSP16_11045) 2327606..2327803 - 198 WP_071536305.1 CrpP family ICE-associated protein -
LSP16_RS11060 (LSP16_11050) 2328303..2328791 - 489 WP_121372661.1 single-stranded DNA-binding protein -
LSP16_RS11065 (LSP16_11055) 2328805..2329335 - 531 WP_121372660.1 DUF3158 family protein -
LSP16_RS11070 (LSP16_11060) 2329341..2330069 - 729 WP_009315862.1 TIGR03761 family integrating conjugative element protein -
LSP16_RS11075 (LSP16_11065) 2330226..2330396 - 171 WP_231786506.1 hypothetical protein -
LSP16_RS11080 (LSP16_11070) 2330736..2332061 - 1326 WP_121372659.1 STY4528 family pathogenicity island replication protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2321246..2344961 23715


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-124)

Antitoxin

SpoVT-AbrB domain

(7-33)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15422.76 Da        Isoelectric Point: 7.3233

>T227603 WP_033993319.1 NZ_CP089067:2326685-2327095 [Pseudomonas aeruginosa]
MLKFMLDTNICIFTIKNRPQEVREAFLRHHDQMCISTVTLMELIYGAEKSSNPSRNLADVEGFAARLEVLKYDQEAAAHT
GQLRAELARLGKQIGPYDQMIAGHARSQGLIVVTNNRREFDRVPGLRVEDWVAPIV

Download         Length: 411 bp

>T227603 NZ_CP123002:296234-296557 [Neorhizobium petrolearium]
ATGAAGGCAATTGAATGGCTTGGAAGCAGCCGCGCGGATGTTCGGTCGTTTCCCGACGATGCGCGTGTAGAGGCGGGCTG
GCAGCTCGAACTTGTCCAGCGCGGCGACGACCCCGATGACTGGAAACCTATGCAGGCCGTGGGGCCAGGCGTCAGAGAAA
TCAGGATTCGTGAGGCATCGGGAGCGTTCCGCGTCATCTATCTGGCAACAGTAGAGGATCGCGTTCTGGTACTGCATGCG
TTCCAGAAGAAGACGCAGGCCCCCTCAAAGAAAGACCTTGATTTGGCGGCCCAACGGCTGAAACGATGGAAGGCAGAACG
ATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8420.29 Da        Isoelectric Point: 4.2821

>AT227603 WP_031634724.1 NZ_CP089067:2326455-2326685 [Pseudomonas aeruginosa]
VEQGSVFQSNRSQAVRLPKAVALPDDVKRVDVVAVGRARIITPAGESWDSWFDGEGVTADFMAEREQPADQERETF

Download         Length: 231 bp

>AT227603 NZ_CP123002:296554-296835 [Neorhizobium petrolearium]
ATGAACGTAGAAATCTATGAAAACGTCTGGGATGCTCTGGCGGACACGGAACAGGAGGCCGCGAACCTGAAGGCGCGCTC
GGCGCTGCTCTACGAAATCCGTAAGGCAGTCCACCGCTGGGACGTTCCGCAGGAGGAGGCCGCCAAGCGGCTTGGTCTGA
CGCGCCCCCGCACCAATGATCTGCTGCGCGGCAAACTCGCCAAGTTCTCGCTTGACGCGCTGGTCAACATCGCTGCATCA
GCGCATCTGGATATTGAAATCCGAGTAAAAGAGGCAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References