Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/RHH(antitoxin) |
| Location | 818233..818738 | Replicon | chromosome |
| Accession | NZ_CP089067 | ||
| Organism | Pseudomonas aeruginosa strain UNC_PaerCF19 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | V6A7K8 |
| Locus tag | LSP16_RS03985 | Protein ID | WP_003083773.1 |
| Coordinates | 818457..818738 (+) | Length | 94 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | Q9I707 |
| Locus tag | LSP16_RS03980 | Protein ID | WP_003112628.1 |
| Coordinates | 818233..818460 (+) | Length | 76 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LSP16_RS03955 (LSP16_03910) | 813251..814744 | + | 1494 | WP_003101230.1 | CoA-acylating methylmalonate-semialdehyde dehydrogenase | - |
| LSP16_RS03960 (LSP16_03915) | 814913..816340 | + | 1428 | WP_003083784.1 | GABA permease | - |
| LSP16_RS03965 (LSP16_03920) | 816422..816763 | - | 342 | WP_003101229.1 | zinc ribbon domain-containing protein YjdM | - |
| LSP16_RS03970 (LSP16_03925) | 816836..817336 | - | 501 | WP_003112629.1 | LEA type 2 family protein | - |
| LSP16_RS03975 (LSP16_03930) | 817437..818057 | + | 621 | WP_003101226.1 | hypothetical protein | - |
| LSP16_RS03980 (LSP16_03935) | 818233..818460 | + | 228 | WP_003112628.1 | CopG family ribbon-helix-helix protein | Antitoxin |
| LSP16_RS03985 (LSP16_03940) | 818457..818738 | + | 282 | WP_003083773.1 | type II toxin-antitoxin system toxin ParE | Toxin |
| LSP16_RS03990 (LSP16_03945) | 819038..819946 | + | 909 | WP_003083769.1 | LysR family transcriptional regulator | - |
| LSP16_RS03995 (LSP16_03950) | 819978..820388 | - | 411 | WP_003101225.1 | aegerolysin family protein | - |
| LSP16_RS04000 (LSP16_03955) | 820568..821302 | - | 735 | WP_003117208.1 | GntR family transcriptional regulator | - |
| LSP16_RS04005 (LSP16_03960) | 821403..822089 | - | 687 | WP_003083762.1 | FadR/GntR family transcriptional regulator | - |
| LSP16_RS04010 (LSP16_03965) | 822138..823487 | - | 1350 | WP_003142411.1 | C4-dicarboxylate transporter DctA | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 94 a.a. Molecular weight: 10462.19 Da Isoelectric Point: 10.0435
>T227601 WP_003083773.1 NZ_CP089067:818457-818738 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP
Download Length: 282 bp
>T227601 NZ_CP123001:596640-597155 [Neorhizobium petrolearium]
ATGCCTGAACCGGAAGAGGAGGCACTGTTCCTCTGGCGGGCTTATGTGCCGCGCTGGGCGCATGCGCCGCTTTCCGGCGA
TGGTGCAGCACGCTTCGGCGGGCGCTGGAACCCGGTCGGGTCGCCGACCATCTATGCCGCCCGCGAGCTTTCCACCGCCT
GGGCCGAATACAATCAGGGCTTCGTGCAGCATCCGGCCCTGATCGCGCAGCTTCGGCTCACAGGAGCACGGCTGGCGAAC
CTCATCGATCCGGCCGCGCTTGCGGACCACGGCGTCAATGAAGCCATCCATCACTGTGAATGGCGGGCGGACCTTGATGC
CGGGCGGTTGCCGGCGACCCATGCCTTGAGAGAGAGGCTCGTCGACCAAGGCTTTGACGGCGTCGTCTACCCGTCCTTCA
TGTCACCCGGTGGCACATGCGTGGCGCTCTGGCGCTGGAATGGGCAGGGGGAACCGAGCCTGATCGTCATCGATCCGGAC
GGGCGGCTGCCGAGGAATGCCGCATCCTGGCTATGA
ATGCCTGAACCGGAAGAGGAGGCACTGTTCCTCTGGCGGGCTTATGTGCCGCGCTGGGCGCATGCGCCGCTTTCCGGCGA
TGGTGCAGCACGCTTCGGCGGGCGCTGGAACCCGGTCGGGTCGCCGACCATCTATGCCGCCCGCGAGCTTTCCACCGCCT
GGGCCGAATACAATCAGGGCTTCGTGCAGCATCCGGCCCTGATCGCGCAGCTTCGGCTCACAGGAGCACGGCTGGCGAAC
CTCATCGATCCGGCCGCGCTTGCGGACCACGGCGTCAATGAAGCCATCCATCACTGTGAATGGCGGGCGGACCTTGATGC
CGGGCGGTTGCCGGCGACCCATGCCTTGAGAGAGAGGCTCGTCGACCAAGGCTTTGACGGCGTCGTCTACCCGTCCTTCA
TGTCACCCGGTGGCACATGCGTGGCGCTCTGGCGCTGGAATGGGCAGGGGGAACCGAGCCTGATCGTCATCGATCCGGAC
GGGCGGCTGCCGAGGAATGCCGCATCCTGGCTATGA
Antitoxin
Download Length: 76 a.a. Molecular weight: 8568.64 Da Isoelectric Point: 5.5740
>AT227601 WP_003112628.1 NZ_CP089067:818233-818460 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ
Download Length: 228 bp
>AT227601 NZ_CP123001:596276-596647 [Neorhizobium petrolearium]
ATGACTGCACATGCATTCGAAATGAGCGCTGCCTCCTTCAGTGAGGCGCACTCCTCTTTCCTCTCTGCGCGGCGTGTTTC
CGAATTGCTCGGCGTGACGCAGGTCGAGTTGGCAAAGCTGATCGGCGTCGCCCGCAACACGCTGACCGCCAAAAGCGGCG
CACGCAAGGTCGACCTCGCACTCTCTCCCGTCGTCCGCATTCTCGCCATGGCGAGCGAGATGGCCGGCGACGAGAACCGC
GCCGCAATCTGGTTCAAGCATCAGCCGATCCCCGGCTGGGCCGGCAAGACGGCTTATGACCTCGTCGGCGAGGGCAAGGC
TGACAAGGTGCTTGCCTATCTGGAGGCGGTGCGTTCCGGCGTCTATGCCTGA
ATGACTGCACATGCATTCGAAATGAGCGCTGCCTCCTTCAGTGAGGCGCACTCCTCTTTCCTCTCTGCGCGGCGTGTTTC
CGAATTGCTCGGCGTGACGCAGGTCGAGTTGGCAAAGCTGATCGGCGTCGCCCGCAACACGCTGACCGCCAAAAGCGGCG
CACGCAAGGTCGACCTCGCACTCTCTCCCGTCGTCCGCATTCTCGCCATGGCGAGCGAGATGGCCGGCGACGAGAACCGC
GCCGCAATCTGGTTCAAGCATCAGCCGATCCCCGGCTGGGCCGGCAAGACGGCTTATGACCTCGTCGGCGAGGGCAAGGC
TGACAAGGTGCTTGCCTATCTGGAGGCGGTGCGTTCCGGCGTCTATGCCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|