Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3736466..3737687 Replicon chromosome
Accession NZ_CP089065
Organism Pseudomonas aeruginosa strain UNC_PaerCF34

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LSP20_RS17620 Protein ID WP_023518577.1
Coordinates 3736466..3737044 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LSP20_RS17625 Protein ID WP_003088112.1
Coordinates 3737133..3737687 (-) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSP20_RS17605 (LSP20_17610) 3731742..3733019 + 1278 WP_003122808.1 TolC family protein -
LSP20_RS17610 (LSP20_17615) 3733009..3735180 + 2172 WP_009876279.1 type I secretion system permease/ATPase -
LSP20_RS17615 (LSP20_17620) 3735170..3736357 + 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
LSP20_RS17620 (LSP20_17625) 3736466..3737044 - 579 WP_023518577.1 HD domain-containing protein Toxin
LSP20_RS17625 (LSP20_17630) 3737133..3737687 - 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
LSP20_RS17630 (LSP20_17635) 3737845..3740040 - 2196 WP_023518578.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
LSP20_RS17635 (LSP20_17640) 3740045..3740506 - 462 WP_003102736.1 (2Fe-2S)-binding protein -
LSP20_RS17640 (LSP20_17645) 3740837..3741160 + 324 WP_023875494.1 multidrug efflux SMR transporter -
LSP20_RS17645 (LSP20_17650) 3741173..3741571 + 399 WP_023082958.1 NADH-quinone oxidoreductase subunit A -
LSP20_RS17650 (LSP20_17655) 3741568..3742119 - 552 WP_003102727.1 XRE family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21815.66 Da        Isoelectric Point: 5.3577

>T227597 WP_023518577.1 NZ_CP089065:c3737044-3736466 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLNY
GRRYTDRAPLFKTLRELLDARTRQCLAARRDA

Download         Length: 579 bp

>T227597 NZ_CP123000:c2998117-2997716 [Neorhizobium petrolearium]
ATGCTGAAGTACATGTTGGACACCAACATCTGCCTTTTTACGATCAAGAATCGGCCGCAGCACGTGCGCGAGGCGTTCAA
CCGTCATCATGGTCAGTTGTGCATCAGCTCGGTTAGCTTGATGGAGTTGATTTACAGGGCGGAAAAGTCAGCCAGTCCGG
AAAAAAATCTGCCCGTTGTAGAGGGCTTCGCCGCGCGCCTCGAGGTGCTACCCTACGACGCAATGGCAGCCAGCCATACA
GGTCAATTACGCGCCGAGCTGGCGCGCAGTGGAACTCCGATCGGACCCTATGATCAGCTGATCGCGGGACACGCTCGCTC
GCGAGGGCTGATTATGGTCACGAATAATCGTCGTGAATTTGATCGGGTGCCCGGTTTACGGGTCGCAGACTGTACCGCTT
AG

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT227597 WP_003088112.1 NZ_CP089065:c3737687-3737133 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT227597 NZ_CP123000:c2998347-2998117 [Neorhizobium petrolearium]
ATGGAGCAGGGTGCAGTATTCCAGAGCAATCGAAGCCAAGCTGTGCGTCTGCCGAAGGCCGTCGCTTTGCCTGCTGATGT
GAAGCGCGTCGATATTGTCGCCGTCGGACGCACTCGCATTATCGCACCTGCTGGCGAGGTCTGGGACAGCTGGTTTGAAG
GAGCGACGGTGACATCGGACTTTATGAATGAGCGTGATCAGCCCGCTTCGCAGGAGCGCGAGGCATTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References