Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 2777017..2778275 Replicon chromosome
Accession NZ_CP089065
Organism Pseudomonas aeruginosa strain UNC_PaerCF34

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag LSP20_RS13050 Protein ID WP_003123189.1
Coordinates 2777520..2778275 (+) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag LSP20_RS13045 Protein ID WP_003086329.1
Coordinates 2777017..2777385 (+) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSP20_RS13025 (LSP20_13030) 2773180..2773455 + 276 WP_010792073.1 zinc ribbon domain-containing protein -
LSP20_RS13030 (LSP20_13035) 2773458..2773934 - 477 WP_003112531.1 hypothetical protein -
LSP20_RS13035 (LSP20_13040) 2774109..2775602 + 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
LSP20_RS13040 (LSP20_13045) 2775658..2776944 + 1287 WP_003123190.1 FAD-binding oxidoreductase -
LSP20_RS13045 (LSP20_13050) 2777017..2777385 + 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
LSP20_RS13050 (LSP20_13055) 2777520..2778275 + 756 WP_003123189.1 RES family NAD+ phosphorylase Toxin
LSP20_RS13055 (LSP20_13060) 2779043..2780404 + 1362 WP_003081943.1 DNA recombination protein RmuC -
LSP20_RS13060 (LSP20_13065) 2780559..2783102 - 2544 WP_003123188.1 acyl-homoserine-lactone acylase QuiP -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(63-207)

Antitoxin

(23-47)


Sequences


Toxin        


Download         Length: 252 a.a.        Molecular weight: 28267.46 Da        Isoelectric Point: 8.3428

>T227596 WP_003123189.1 NZ_CP089065:2777520-2778275 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGMRLQAPPFSDHEAALTDIA
DYRAPQKLGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

>T227596 NZ_CP123000:c2992112-2991759 [Neorhizobium petrolearium]
ATGAGGCGGGGGGATATCTGGACGGTCGCGGGCGGCAAGGATTACGCGGGCAAACCGCGTCCGGTCGTGATCATGCAGGA
CGACAGTTTCGACGGGACGGATTCGATCACCGTCTGCGCCTTCACATCGGATGATACGGAAGCGCCGTTGTTTCGGCTTC
CCGTTGCCCCGGACGAGCGCAATGGCCTGCGGCTGTCTTCCCGCCTGATGGTGGACAAGATCACCACCGTCCCGAAATCG
AAGATCGGCGAGAAAGTCGGACGGCTGGACGACGAAGATATAGTGCGACTCAATCAGGCGATGCTGGTTTTTCTCGGGCT
TGCCGTGTCGCCAAGGGTAAGGGGAGAGGCTTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT227596 WP_003086329.1 NZ_CP089065:2777017-2777385 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp

>AT227596 NZ_CP123000:c2992333-2992109 [Neorhizobium petrolearium]
ATGGTTTCCGCATCAAAGCCGAAGCCTACGCGCGTAAAGGTGGGCGAACATCGCGCCCGGCTGCGTGCTCAAGGTCTGCG
TCCGATCCAAATTTGGGTGCCGGACGTGCGTGCGCCCTCATTCAAGGTCGAGGCTCACCGCCAGTCGCTTGCGGTCGCGG
CAAGCGCACAGGCGGCGGACGATCAGGCGTTTATCGATGCCGTCTCCGATTGGGGCGATGAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References