227593

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 4689667..4691175 Replicon chromosome
Accession NZ_CP089064
Organism Pseudomonas aeruginosa strain UNC_PaerCF35

Toxin (Protein)


Gene name - Uniprot ID Q9HYX1
Locus tag LSP22_RS21845 Protein ID WP_003119682.1
Coordinates 4689667..4690254 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A7M2ZM82
Locus tag LSP22_RS21850 Protein ID WP_023087137.1
Coordinates 4690321..4691175 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSP22_RS21840 (LSP22_21840) 4685922..4689401 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
LSP22_RS21845 (LSP22_21845) 4689667..4690254 + 588 WP_003119682.1 GNAT family protein Toxin
LSP22_RS21850 (LSP22_21850) 4690321..4691175 + 855 WP_023087137.1 AraC family transcriptional regulator Antitoxin
LSP22_RS21855 (LSP22_21855) 4691272..4693437 + 2166 WP_009876821.1 TonB-dependent receptor family protein -
LSP22_RS21860 (LSP22_21860) 4693612..4695486 + 1875 WP_231821972.1 MFS transporter -
LSP22_RS21865 (LSP22_21865) 4695547..4695756 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21901.23 Da        Isoelectric Point: 9.8676

>T227593 WP_003119682.1 NZ_CP089064:4689667-4690254 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T227593 NZ_CP123000:2615113-2615301 [Neorhizobium petrolearium]
ATGAGAAGCGCTGAGGTAATTGCGCTGCTGCGCAAGGATGGCTGGATCGAGCTGGCCCAGAAAGGCAGCCATGTTCAGTT
CAAGCATCCGGAAAAGCCGGGACGCGTCACCGTTCCTCATCCGAAGCGCGACATCCCGCTCGGCACGCTCCGCAGCATCG
AGAAACAGGCGGGACTGAAACTGAGGTAA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31925.22 Da        Isoelectric Point: 7.5295

>AT227593 WP_023087137.1 NZ_CP089064:4690321-4691175 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHSGVPRFADSVIHDQPLARAFVHLHRLLAEHAGSLETQTRWRETMLALFRRH
ARLPEAPKAGQEPLAVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTTYE

Download         Length: 855 bp

>AT227593 NZ_CP123000:2615304-2615708 [Neorhizobium petrolearium]
ATGAGCAACTATATCGGCCTCATCCGCAAGGAAGCAGGAAGTGACTATGGTGTCTCCTTCCCGGACTTCCCGGGCGTCGT
AACCGCAGGCTCGACCTTGGACGAGGCCCGTCAGATGGCCGAAGAAGCGCTTGCATTCCACGTGGAGGGCATGGCTGAGG
ATGGCGAGGCGGTCCCTGAACCATCGAGCCTGGAGGGCGTGATGAGCGATCCAGCCAATCGGGACGGGGTAGCGATTCTC
GTGAGCTTGAAGACGCAGGCAGCCAAAGCCGTACGTATCAATGTCACGCTGCCGGAAGACGTGCTTCAGCGGATCGACAC
CTTCGCGGAGGCGAGCGGCCTCTCGCGCTCTGGTTTTCTCGCAAGGGCAGCGCGACACGAGATGGAGCGCAACACAGCGG
TTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 1YRE
PDB 8GXJ

Antitoxin

Source ID Structure
AlphaFold DB A0A7M2ZM82

References