Detailed information of TA system TA227584

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4211908..4213165
• Replicon: chromosome
• Accession: NZ_CP089063
• Organism: Pseudomonas aeruginosa strain UNC_PaerCF37

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LSP18_RS19545
• Protein ID: WP_003449003.1
• Coordinates: 4211908..4212663 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: LSP18_RS19550
• Protein ID: WP_003086329.1
• Coordinates: 4212797..4213165 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LSP18_RS19535 (LSP18_19710)	4207081..4209624	+	2544	WP_003140632.1	acyl-homoserine-lactone acylase QuiP	-
LSP18_RS19540 (LSP18_19715)	4209779..4211140	-	1362	WP_003081943.1	DNA recombination protein RmuC	-
LSP18_RS19545 (LSP18_19720)	4211908..4212663	-	756	WP_003449003.1	RES family NAD+ phosphorylase	Toxin
LSP18_RS19550 (LSP18_19725)	4212797..4213165	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
LSP18_RS19555 (LSP18_19730)	4213238..4214524	-	1287	WP_003112529.1	FAD-binding oxidoreductase	-
LSP18_RS19560 (LSP18_19735)	4214580..4216073	-	1494	WP_003086325.1	aldehyde dehydrogenase family protein	-
LSP18_RS19565 (LSP18_19740)	4216248..4216724	+	477	WP_003112531.1	hypothetical protein	-
LSP18_RS19570 (LSP18_19745)	4216727..4217002	-	276	WP_010792073.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28292.45 Da
• Isoelectric Point: 7.7294

>T227584 WP_003449003.1 NZ_CP089063:c4212663-4211908 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T227584 NZ_CP122997:78281-78652 [Mycolicibacterium aubagnense]
ATGGCCTCGACTGAACCGCGCCGTGGCGAACTCTGGCTCGCCGCACTTGGCGCCGGCCGGGCGGGCGAGCCCGCCAAACA
CCGGCCAGCAGTCGTCGTTTCCGCCGATGACCTGCTCACCGGAGAACCCACCGAACTCGTTGTCGTCGTACCGGTTTCGA
GTTCGCGGACATCGACACCGCTGCGGCCGACAATCAGGCCCAACGAGGGCGTCGAAACCGACAGCGTGGCTGTCTGCCGC
GCTATTCGAGGCATGGCCCGAGCCCGCCTTGTGCGCCATCTTGGAACACTCGACACTCACACGATGGATGCGATCGAGAA
ATCGTTGGCGCTCATTCTCGACATCGAACAGCCCGGTCGTCGCGATAAGTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT227584 WP_003086329.1 NZ_CP089063:c4213165-4212797 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT227584 NZ_CP122997:78697-78924 [Mycolicibacterium aubagnense]
ATGGCCAACCGCGACATCAACAGGCGAGTCGCCGACCACCGCACCCGCCTGCGCGAACAAGGACTGCGCCCACTCCAAAT
ATGGGTACCCGACACTCGCGCACCAGGATTCGCAGAGGAAGCTCACCGCCAGTCAGCCCTCGTAGCCGCCTCCAGCAGCG
CAGCCGAGGACCAGGCCTTCGTGGACAATATCTCGCAGTTCAATGATGAGGACTTCGACGCCGAGTGA

Structures

Antitoxin

• AlphaFold DB: V6AJU7