Detailed information of TA system TA227583

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 3218707..3219928
• Replicon: chromosome
• Accession: NZ_CP089063
• Organism: Pseudomonas aeruginosa strain UNC_PaerCF37

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: LSP18_RS14880
• Protein ID: WP_034011388.1
• Coordinates: 3219350..3219928 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: LSP18_RS14875
• Protein ID: WP_003117666.1
• Coordinates: 3218707..3219261 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LSP18_RS14850 (LSP18_14975)	3214275..3214826	+	552	WP_003102727.1	XRE family transcriptional regulator	-
LSP18_RS14855 (LSP18_14980)	3214823..3215221	-	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
LSP18_RS14860 (LSP18_14985)	3215234..3215557	-	324	WP_023119961.1	multidrug efflux SMR transporter	-
LSP18_RS14865 (LSP18_14990)	3215888..3216349	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
LSP18_RS14870 (LSP18_14995)	3216354..3218549	+	2196	WP_004349295.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
LSP18_RS14875 (LSP18_15000)	3218707..3219261	+	555	WP_003117666.1	helix-turn-helix transcriptional regulator	Antitoxin
LSP18_RS14880 (LSP18_15005)	3219350..3219928	+	579	WP_034011388.1	HD domain-containing protein	Toxin
LSP18_RS14885 (LSP18_15010)	3220037..3221224	-	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
LSP18_RS14890 (LSP18_15015)	3221214..3223385	-	2172	WP_003114950.1	type I secretion system permease/ATPase	-
LSP18_RS14895 (LSP18_15020)	3223375..3224652	-	1278	WP_003102743.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	phzG1 / phzF1 / phzE1 / phzD1 / phzC1 / phzB1 / phzA1 / lasA / tse1	3171115..3321710	150595

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (7-188)

Antitoxin

• Cro/C1-type helix-turn-helix domain (11-66)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21882.74 Da
• Isoelectric Point: 5.6214

>T227583 WP_034011388.1 NZ_CP089063:3219350-3219928 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKNVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRERLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T227583 NZ_CP122997:78281-78652 [Mycolicibacterium aubagnense]
ATGGCCTCGACTGAACCGCGCCGTGGCGAACTCTGGCTCGCCGCACTTGGCGCCGGCCGGGCGGGCGAGCCCGCCAAACA
CCGGCCAGCAGTCGTCGTTTCCGCCGATGACCTGCTCACCGGAGAACCCACCGAACTCGTTGTCGTCGTACCGGTTTCGA
GTTCGCGGACATCGACACCGCTGCGGCCGACAATCAGGCCCAACGAGGGCGTCGAAACCGACAGCGTGGCTGTCTGCCGC
GCTATTCGAGGCATGGCCCGAGCCCGCCTTGTGCGCCATCTTGGAACACTCGACACTCACACGATGGATGCGATCGAGAA
ATCGTTGGCGCTCATTCTCGACATCGAACAGCCCGGTCGTCGCGATAAGTGA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.67 Da
• Isoelectric Point: 8.5356

>AT227583 WP_003117666.1 NZ_CP089063:3218707-3219261 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADKALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT227583 NZ_CP122997:78058-78294 [Mycolicibacterium aubagnense]
GTGTCTACACCTACGACCACAATTCGCGTACCGGTCACCACCCGTGACCGCTTGAACGCGCAGGCCCGCGACCGCGGCAT
CTCCGTCGTAGCACTCCTGGACGAGTGGTCCAACCGGGCCGAGCGGGACGCAGCATTCGCGGCCGAACGCGCTGCCACCC
TGGCTGAAGCCACCAACCAGGCCATCCTGGAAGAAGACCGCGACTGGGAGCAGACGGAAACCGATGGCCTCGACTGA