Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 2261604..2262646 | Replicon | chromosome |
| Accession | NZ_CP089063 | ||
| Organism | Pseudomonas aeruginosa strain UNC_PaerCF37 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | LSP18_RS10680 | Protein ID | WP_003109777.1 |
| Coordinates | 2262071..2262646 (+) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | I3TV68 |
| Locus tag | LSP18_RS10675 | Protein ID | WP_003050245.1 |
| Coordinates | 2261604..2262074 (+) | Length | 157 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LSP18_RS10640 (LSP18_10705) | 2256996..2258414 | - | 1419 | WP_020924934.1 | TIGR03752 family integrating conjugative element protein | - |
| LSP18_RS10645 (LSP18_10710) | 2258404..2259315 | - | 912 | WP_003105643.1 | TIGR03749 family integrating conjugative element protein | - |
| LSP18_RS10650 (LSP18_10715) | 2259312..2260004 | - | 693 | WP_003105641.1 | TIGR03746 family integrating conjugative element protein | - |
| LSP18_RS10655 (LSP18_10720) | 2260001..2260399 | - | 399 | WP_003105639.1 | TIGR03750 family conjugal transfer protein | - |
| LSP18_RS10660 (LSP18_10725) | 2260411..2260770 | - | 360 | WP_003090173.1 | TIGR03745 family integrating conjugative element membrane protein | - |
| LSP18_RS10665 (LSP18_10730) | 2260787..2261020 | - | 234 | WP_003050225.1 | TIGR03758 family integrating conjugative element protein | - |
| LSP18_RS10670 (LSP18_10735) | 2261017..2261400 | - | 384 | WP_003120001.1 | RAQPRD family integrative conjugative element protein | - |
| LSP18_RS10675 (LSP18_10740) | 2261604..2262074 | + | 471 | WP_003050245.1 | helix-turn-helix domain-containing protein | Antitoxin |
| LSP18_RS10680 (LSP18_10745) | 2262071..2262646 | + | 576 | WP_003109777.1 | PIN domain-containing protein | Toxin |
| LSP18_RS10685 (LSP18_10750) | 2262664..2263578 | + | 915 | WP_003105629.1 | AAA family ATPase | - |
| LSP18_RS10690 (LSP18_10755) | 2263575..2264045 | + | 471 | WP_057390687.1 | type III CBASS phage resistance system CD-NTase-associated protein Cap8 | - |
| LSP18_RS10695 (LSP18_10760) | 2264042..2264542 | + | 501 | WP_003090159.1 | type III CBASS phage resistance system CD-NTase-associated protein Cap7 | - |
| LSP18_RS10700 (LSP18_10765) | 2264542..2265444 | + | 903 | WP_003105624.1 | CBASS oligonucleotide cyclase | - |
| LSP18_RS10705 (LSP18_10770) | 2265483..2266208 | + | 726 | WP_003050273.1 | CBASS effector endonuclease NucC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 2190499..2312177 | 121678 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21644.79 Da Isoelectric Point: 5.6172
>T227582 WP_003109777.1 NZ_CP089063:2262071-2262646 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPDDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIEVDRYLEILLRQGLVQTTKVLATYRTIL
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPDDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIEVDRYLEILLRQGLVQTTKVLATYRTIL
Download Length: 576 bp
>T227582 NZ_CP122994:c5018553-5018116 [Mycolicibacterium aubagnense]
ATGGCAAAGCTCGCAAGTTCTATCGAAGTGCCCCTGTCCCCTGAAAAGGCATGGGAGGCAGCGTCGGACCTCTCCCGGTA
CGACGACTGGCTGTCCATCCACCGGATGTGGCGGAGCACGTTGCCCGAGACCTTGGGGAAGGGCACCCAGATCTCGTCCG
TCGTCGAGGTCAAGGGCATGCTGAACCGGGTCGACTGGACCATCGTGCACTACAACCCGCCGGGATCGTTGACCCTCAAC
GGTGTCGGCAAGGGCGGCGTCCGGGTCAAGTTGATGGCCAAGATCACGCCGGCCGAAGCCGGTTCGAACGTGGCGTTCGA
CGTCCACCTGGGTGGTCCGGCCCTGTTCGGCCCCATCGGCATGGTGGTGGCGGCCGCGCTGCGGTCCGACATCCACCACT
CGCTGGAGAAATTCAAGGCGCTGTTCGCGTCGGTGTAG
ATGGCAAAGCTCGCAAGTTCTATCGAAGTGCCCCTGTCCCCTGAAAAGGCATGGGAGGCAGCGTCGGACCTCTCCCGGTA
CGACGACTGGCTGTCCATCCACCGGATGTGGCGGAGCACGTTGCCCGAGACCTTGGGGAAGGGCACCCAGATCTCGTCCG
TCGTCGAGGTCAAGGGCATGCTGAACCGGGTCGACTGGACCATCGTGCACTACAACCCGCCGGGATCGTTGACCCTCAAC
GGTGTCGGCAAGGGCGGCGTCCGGGTCAAGTTGATGGCCAAGATCACGCCGGCCGAAGCCGGTTCGAACGTGGCGTTCGA
CGTCCACCTGGGTGGTCCGGCCCTGTTCGGCCCCATCGGCATGGTGGTGGCGGCCGCGCTGCGGTCCGACATCCACCACT
CGCTGGAGAAATTCAAGGCGCTGTTCGCGTCGGTGTAG
Antitoxin
Download Length: 157 a.a. Molecular weight: 17245.62 Da Isoelectric Point: 6.3803
>AT227582 WP_003050245.1 NZ_CP089063:2261604-2262074 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
Download Length: 471 bp
>AT227582 NZ_CP122994:c5018774-5018556 [Mycolicibacterium aubagnense]
ATGGGATTTCTGGACAAGGTGAAGGACCTGGCGGCGCAGAACGCCGACAAGGTCGAGGCCGCTATCGAGAAGGTCGGCGA
CATCGTCGACGAGAAGACCGACGGCAAGTTCAAGAGCGTCGTCGACAGCGCGCAGGAAGCCGCCAAGAAGGCTGTGGCCG
GCGAGCAGCCTGCTGAGGCTCCCGCGCCGCCGGCCGAGGGGACGCAAGAACAACAGTAG
ATGGGATTTCTGGACAAGGTGAAGGACCTGGCGGCGCAGAACGCCGACAAGGTCGAGGCCGCTATCGAGAAGGTCGGCGA
CATCGTCGACGAGAAGACCGACGGCAAGTTCAAGAGCGTCGTCGACAGCGCGCAGGAAGCCGCCAAGAAGGCTGTGGCCG
GCGAGCAGCCTGCTGAGGCTCCCGCGCCGCCGGCCGAGGGGACGCAAGAACAACAGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|