Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 1400584..1402092 Replicon chromosome
Accession NZ_CP089063
Organism Pseudomonas aeruginosa strain UNC_PaerCF37

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag LSP18_RS06490 Protein ID WP_079382890.1
Coordinates 1400584..1401171 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag LSP18_RS06495 Protein ID WP_012613852.1
Coordinates 1401238..1402092 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSP18_RS06485 (LSP18_06510) 1396839..1400318 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
LSP18_RS06490 (LSP18_06515) 1400584..1401171 + 588 WP_079382890.1 GNAT family protein Toxin
LSP18_RS06495 (LSP18_06520) 1401238..1402092 + 855 WP_012613852.1 AraC family transcriptional regulator Antitoxin
LSP18_RS06500 (LSP18_06525) 1402189..1404354 + 2166 WP_003091606.1 TonB-dependent receptor family protein -
LSP18_RS06505 (LSP18_06530) 1404529..1406403 + 1875 WP_003091605.1 MFS transporter -
LSP18_RS06510 (LSP18_06535) 1406464..1406673 - 210 WP_003091604.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21818.16 Da        Isoelectric Point: 9.5531

>T227581 WP_079382890.1 NZ_CP089063:1400584-1401171 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGCTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAALEASFTG

Download         Length: 588 bp

>T227581 NZ_CP122989:16348-16623 [Aeromonas salmonicida]
ATGGAACTGAAATGGACCAGCAAGGCGCTCTCTGATTTGGCGCGCCTGTATGAATTTCTGGCGCTGGCGAACAAGCCCGC
AGCGGCTCGGGCGGTGCAGGCACTGACACAAGCCCCGACCATTCTGCTAACCAACCCACGGATTGGAGAGCAACTATTTC
AGTTTGAGCCCCGCGAGGTGAGGCGGATTTTAGTTGGGGAGTACGAGGTTCGTTACGAGATCCTAGATTCAATCATCTAC
GTCCTACGGCTATGGCATACGCGAGAAAATCGTTGA

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31959.27 Da        Isoelectric Point: 7.3276

>AT227581 WP_012613852.1 NZ_CP089063:1401238-1402092 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHADSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLPVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp

>AT227581 NZ_CP122989:16067-16348 [Aeromonas salmonicida]
ATGAAGGGCAACATGACACAAGCAACAACCAAGGTGCTGACGGCACACGTACCACTACCGATGGCCGACAAAGTTGACCA
GATGGCTGCCCGCCTTGAACGCTCGCGCGGCTGGATCATGAAACAGGCTCTTTCCGCATGGCTCGCCCAGGAAGAAGATC
GTGATCGCCTGACCCAAGAGGCGCTGGCAGACGTGGATGCGGGTCGAGTTATCGATCACCTGGCGGTGCAGGCTTGGGCT
GACAGTCTCAACACAGACCAGCCGCTGTCGGTGCCGCGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References