Detailed information of TA system TA227579

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 5689072..5690330
• Replicon: chromosome
• Accession: NZ_CP089062
• Organism: Pseudomonas aeruginosa strain UNC_PaerCF38

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: LSP17_RS26185
• Protein ID: WP_034047924.1
• Coordinates: 5689072..5689827 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: LSP17_RS26190
• Protein ID: WP_003086329.1
• Coordinates: 5689962..5690330 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LSP17_RS26175 (LSP17_26180)	5684244..5686787	+	2544	WP_034047923.1	acyl-homoserine-lactone acylase QuiP	-
LSP17_RS26180 (LSP17_26185)	5686942..5688303	-	1362	WP_003081943.1	DNA recombination protein RmuC	-
LSP17_RS26185 (LSP17_26190)	5689072..5689827	-	756	WP_034047924.1	RES family NAD+ phosphorylase	Toxin
LSP17_RS26190 (LSP17_26195)	5689962..5690330	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
LSP17_RS26195 (LSP17_26200)	5690403..5691689	-	1287	WP_003163134.1	FAD-binding oxidoreductase	-
LSP17_RS26200 (LSP17_26205)	5691745..5693238	-	1494	WP_003086325.1	aldehyde dehydrogenase family protein	-
LSP17_RS26205 (LSP17_26210)	5693413..5693889	+	477	WP_003140638.1	hypothetical protein	-
LSP17_RS26210 (LSP17_26215)	5693892..5694167	-	276	WP_170870716.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28304.46 Da
• Isoelectric Point: 7.7080

>T227579 WP_034047924.1 NZ_CP089062:c5689827-5689072 [Pseudomonas aeruginosa]
VSEIWRQCKGERYIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T227579 NZ_CP122987:3363806-3364126 [Aeromonas salmonicida]
ATGAAAGACCATGAGCAGACCGTCACATTCAGTCGTTATGATGCGGCTGACTACCTCAAGACCGATGAAGACATGCTCCA
CTATTTGGAGGCCGTCATGGAAGAGGGCGATCCCGCCTTGATTGCAGCCGCCCTCGGTGACATCGCCCGCGCTCGCAACC
TGAGCCAGCTGGCCCGTGATGTTGGGATGAGCAGAGAGGGGCTATACAAAGCCTTATCCGGAGAAGGCAACCCGACCTTT
GCCACCATAACCAAAGTGGCGGGCGCACTGGGGCTGCGCTTTGGTGTCCACCTTGCCAATCCGCCAGCAACCCACGCGTG
A

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT227579 WP_003086329.1 NZ_CP089062:c5690330-5689962 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT227579 NZ_CP122987:3363507-3363803 [Aeromonas salmonicida]
ATGAGAGAGATAATCAAAACAAACGTGTTCGACCGCTGGTTTGACTCCCTGCGAGATGCTCGCGCACAGGCAAAGGTGAC
AGCCAGGATCCGGCGCTTGGGTCTTGGCAATCCTGGGGACGTTAAACCTATCGGGGAGGGTCTATCGGAAATGCGGATAG
ACTACGGCCCCGGGTACAGAGTGTATTTTATGACAAAAGGCCCGATCATCATCGTGCTGCTGTGCGGTGGGGATAAGGGC
ACCCAAGCCCGTGATATCGAACAGGCAAAAACCATTGCCGCGCAATGGAAGGATTAA

Structures

Antitoxin

• AlphaFold DB: V6AJU7