Detailed information of TA system TA227575

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1361194..1361699
• Replicon: chromosome
• Accession: NZ_CP089062
• Organism: Pseudomonas aeruginosa strain UNC_PaerCF38

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: LSP17_RS06290
• Protein ID: WP_003083773.1
• Coordinates: 1361194..1361475 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: LSP17_RS06295
• Protein ID: WP_003083775.1
• Coordinates: 1361472..1361699 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LSP17_RS06265 (LSP17_06265)	1356445..1357794	+	1350	WP_003142411.1	C4-dicarboxylate transporter DctA	-
LSP17_RS06270 (LSP17_06270)	1357843..1358529	+	687	WP_003083762.1	FadR/GntR family transcriptional regulator	-
LSP17_RS06275 (LSP17_06275)	1358630..1359364	+	735	WP_003083764.1	GntR family transcriptional regulator	-
LSP17_RS06280 (LSP17_06280)	1359544..1359954	+	411	WP_003110659.1	aegerolysin family protein	-
LSP17_RS06285 (LSP17_06285)	1359986..1360894	-	909	WP_003083769.1	LysR family transcriptional regulator	-
LSP17_RS06290 (LSP17_06290)	1361194..1361475	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
LSP17_RS06295 (LSP17_06295)	1361472..1361699	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
LSP17_RS06300 (LSP17_06300)	1361875..1362495	-	621	WP_003101226.1	hypothetical protein	-
LSP17_RS06305 (LSP17_06305)	1362596..1363096	+	501	WP_003101228.1	LEA type 2 family protein	-
LSP17_RS06310 (LSP17_06310)	1363169..1363510	+	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
LSP17_RS06315 (LSP17_06315)	1363592..1365019	-	1428	WP_003083784.1	GABA permease	-
LSP17_RS06320 (LSP17_06320)	1365188..1366681	-	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T227575 WP_003083773.1 NZ_CP089062:c1361475-1361194 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T227575 NZ_CP122962:735206-735604 [Agrobacterium tumefaciens]
ATGCTTACATATATGCTCGATACCAATATATGTATCTATGTGATGAAGACTTATCCTCCCGAGTTGCGGGAGAAGTTCAA
CGATCTGGCAGATCAACTGTGTATTTCGAGCATCACACTCGGCGAGCTTTATTATGGTGCTGAAAAATCCGTCCGGCGCC
AGGAAAACATCAGCGCCATTGAAAATTTTACCGCGCGTTTGGAGGTTCTGCCTTTCGCCGACAAAGGCGCCGCACATTAC
GGCCAGATCAGGGCCGAACTTACCAAGGTTGGAACGCCGTGCGGCGTTCATGATATGCAGATTGGTGGTCACGCCCGTAG
TGAGGGGCTGATCGTCGTAACCAATAATATGCGCGAATTCATTCGTATGCCGGGCTTGCGAGCCGAAAACTGGGTATAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT227575 WP_003083775.1 NZ_CP089062:c1361699-1361472 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT227575 NZ_CP122962:734973-735206 [Agrobacterium tumefaciens]
ATGGCAACGTCAACGGTTTTTATAAGCAATCGCAGTCAAGCTGTAAGGCTACCGAAGGCCGTGGCTTTTCCTGATGACGT
GCATAAGGTCGATGTTCTGAAGATTGGTCTCGCGCGTGTTATAGTGCCGCAGGGAAAGCGCTGGGACGACCTCTTTCTGA
CCGGCCCACGTGCGACGGATGATTTTCTTTCCGTTCGGGAAGAGCCTGCATTGGATGAGCGTGAGCCCTTCTGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9