Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Acetyltransf_4(toxin)
Location 4763989..4765497 Replicon chromosome
Accession NZ_CP089061
Organism Pseudomonas aeruginosa strain UNC_PaerCF41

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag LSP19_RS22015 Protein ID WP_012613851.1
Coordinates 4763989..4764576 (+) Length 196 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID -
Locus tag LSP19_RS22020 Protein ID WP_012613852.1
Coordinates 4764643..4765497 (+) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSP19_RS22010 (LSP19_22010) 4760244..4763723 - 3480 WP_003117605.1 PAS domain-containing hybrid sensor histidine kinase/response regulator -
LSP19_RS22015 (LSP19_22015) 4763989..4764576 + 588 WP_012613851.1 GNAT family protein Toxin
LSP19_RS22020 (LSP19_22020) 4764643..4765497 + 855 WP_012613852.1 AraC family transcriptional regulator Antitoxin
LSP19_RS22025 (LSP19_22025) 4765594..4767759 + 2166 WP_003115567.1 TonB-dependent receptor family protein -
LSP19_RS22030 (LSP19_22030) 4767934..4769808 + 1875 WP_003117607.1 MFS transporter -
LSP19_RS22035 (LSP19_22035) 4769869..4770078 - 210 WP_003115568.1 cold-shock protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(20-152)

Antitoxin

AraC-type arabinose-binding/dimerisation domain

(19-151)


Sequences

Toxin        


Download         Length: 196 a.a.        Molecular weight: 21929.29 Da        Isoelectric Point: 9.8676

>T227573 WP_012613851.1 NZ_CP089061:4763989-4764576 [Pseudomonas aeruginosa]
MSRRAPMFKPLPITLQRGALRLEPLVEADIPELVSLAEANREALQYMDGPTRPDWYRQSLAEQREGRALPLAVRLGVQLV
GTTRFAEFLPALPACEIGWTWLDQAQHGSGLNRMIKYLMLKHAFDNLRMVRVQLSTAASNLRAQGAIDKLGAQREGVLRN
HRRLAGGRLDDTFVYSITDHEWPQVKAVLEASFTG

Download         Length: 588 bp

>T227573 NZ_CP122962:c318805-318536 [Agrobacterium tumefaciens]
GTGATCTGGACAATTGAATATGACACGCTTGTCCAGAAAGAGATGCGCAAGATTCACCCGGAAGTGCGCCGACGCATCCG
GAGCTTTCTCCATGAGAGAATAGCGGCGCTAGATGATCCGCGTCAGACCGGCACCACTCTCCAAGGTTCCGAGCTTGGAA
ATTTCTGGCGTTACCGGGTGGGCGATTACCGCATCATCTGCGATATACAGGATCACAAGCTCGTCGTGCTGGTGGTCGAA
ATCGGCCATCGCCGTGAAATATACCGTTAG

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31959.27 Da        Isoelectric Point: 7.3276

>AT227573 WP_012613852.1 NZ_CP089061:4764643-4765497 [Pseudomonas aeruginosa]
VPDETSGEHTHFWRAAELGGVELLHARYVEQRFAPHVHSSFALVIIEQGAQRFRHRGGEHLAPLGSMVLINPDEVHTGSK
AHDAGWLYRGYYPEMEQIDGILDELEIHHGGVPRFADSVIHDQPLARAFVHLHRLLAEHADSLETQTRWRETVLALFRRH
ARLPEAPKAGQEPLPVARARELLAARLLDPPSLEELAAAVNLSPFHFARVFRRATGMPPHAWLRQRRLEQARALLKSGRA
PLEVALELGFADQSHLGRQFKQAYGVAPGEYRSACARSSLTIYE

Download         Length: 855 bp

>AT227573 NZ_CP122962:c319016-318789 [Agrobacterium tumefaciens]
ATGAGCAAACAGACGGCCATTCGCCTGCCGGATGAGACCTATGAGCGGCTGAAGGCGCTTTCCGAGCGCACCGGCCGTAC
ATCCGCCTATTACATCCGCGAGGCGATCGAGAAGCATATCGAGGATATGGAAGACCTCTATCTTGCGGAAGAGGCGATGC
GGCGCATCCAGCGCGGTGAATCAAAGGTGATAAGCGCCGAGGAGTTCTGGCGTGATCTGGACAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References