Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 4498658..4500353 Replicon chromosome
Accession NZ_CP089061
Organism Pseudomonas aeruginosa strain UNC_PaerCF41

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag LSP19_RS20775 Protein ID WP_048910032.1
Coordinates 4498658..4499527 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q9HYA1
Locus tag LSP19_RS20780 Protein ID WP_003112902.1
Coordinates 4499520..4500353 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSP19_RS20750 (LSP19_20750) 4494666..4495517 + 852 WP_003130104.1 ABC transporter ATP-binding protein -
LSP19_RS20755 (LSP19_20755) 4495558..4496565 + 1008 WP_003162724.1 ABC transporter substrate-binding protein -
LSP19_RS20760 (LSP19_20760) 4496562..4497338 + 777 WP_003112898.1 ABC transporter permease -
LSP19_RS20765 (LSP19_20765) 4497344..4498105 + 762 WP_079274766.1 SDR family oxidoreductase -
LSP19_RS20770 (LSP19_20770) 4498119..4498649 + 531 WP_003162721.1 cupin domain-containing protein -
LSP19_RS20775 (LSP19_20775) 4498658..4499527 + 870 WP_048910032.1 alpha/beta hydrolase Toxin
LSP19_RS20780 (LSP19_20780) 4499520..4500353 + 834 WP_003112902.1 IclR family transcriptional regulator Antitoxin
LSP19_RS20785 (LSP19_20785) 4500340..4501137 + 798 WP_003112903.1 SDR family oxidoreductase -
LSP19_RS20790 (LSP19_20790) 4501130..4502812 + 1683 WP_003112904.1 thiamine pyrophosphate-binding protein -
LSP19_RS20795 (LSP19_20795) 4502823..4503626 + 804 WP_003112905.1 aspartate dehydrogenase -
LSP19_RS20800 (LSP19_20800) 4503638..4505122 + 1485 WP_003163202.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30336.60 Da        Isoelectric Point: 6.5894

>T227572 WP_048910032.1 NZ_CP089061:4498658-4499527 [Pseudomonas aeruginosa]
MNMAQTHIPAPSLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERLGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSPIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

>T227572 NZ_CP122961:c2835530-2835012 [Halomonas alkaliantarctica]
ATGATATTGCTGCCAGAGCTGAAAACTCAGGCATACCGGGTACATGTTCCACGCTGGGCGTTTTCTCCTACGAGTGGGGC
CGGTGCGAGAGAGTATGGCGGGCGGCTGAACCGGGTTGGTGTAGATGCGTTATATCTTTCACTTGAGGAGCAAACAGCGT
TAGCTGAGTACAAGCAGCTTTCTGCATTGATGCCGCCTGGGCTGATTGTCAGCTATACGGTCAGCGTAACTAATATTGTC
GATTTTCGATCAGGCTATCACTCAAAATGGGACAGCCTGTGGCAAGAGCTCAGCTGTGACTGGCGTAAGTATTGGTTTAA
TCAACGTATTGAGCCGCCGAGCTGGCTATTAGGCGATATGGCGTTGGAGCAAGGTGCTAAGGGGATACTTTTTCCTTCGT
TGGCATGCGGCTTAGGCATAAACCTTGTGCTCTATACCGAAACGCTAACAGAAAGCGATACATTAGAGGTCTATGATCCC
CAGGGCGATTTGCCGCGTGATGGGCGCTCCTGGCAGTAA

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30877.26 Da        Isoelectric Point: 5.7725

>AT227572 WP_003112902.1 NZ_CP089061:4499520-4500353 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp

>AT227572 NZ_CP122961:c2835958-2835527 [Halomonas alkaliantarctica]
ATGGCAATGGGCAATGTAAAAGAATCACTTAATGAGCCTTCCGGTTATCTGGTGCCTGATTCGTTCGAGCGGTTTTTGGC
TGACTTGAAGGCCGTTGCTCGAGAAGAGCGCCACCCATTAATTAACCCGAAGTTGTTTGCCAGTGCATTGAGCATCGATA
TTCAAACGCTTGCTAGTCAAGCGCACGTTCATCGTACGACGATCTCACGTGCCCAGGGGGCAGAAAAACTCCAACGTTAT
CTGCGTGATGCACTCCGTGTGCTCGGCGCCGCGGCGGATATTAATGGTGACTTCCATGACGCCCTGTTTTGGTTTCGCAA
TGAGCCGCTGAGTGCGTTTGACTATAAAACACCCGAGCAACTCGTGAGTGAAGGGCGCTCAAATGACCTTCTGCGCTATG
TTCAGTCGCTGCAAGCAGGTGTGGCGGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB Q9HYA1

References