Detailed information of TA system TA022757

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 1629482..1630004
• Replicon: chromosome
• Accession: NC_010513
• Organism: Xylella fastidiosa M12

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: XFASM12_RS07320
• Protein ID: WP_004085905.1
• Coordinates: 1629717..1630004 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A060HDF9
• Locus tag: XFASM12_RS07315
• Protein ID: WP_004085758.1
• Coordinates: 1629482..1629724 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XFASM12_RS07280	1624892..1625074	+	183	WP_027700467.1	hypothetical protein	-
XFASM12_RS07285	1625358..1626284	-	927	WP_004085766.1	Grx4 family monothiol glutaredoxin	-
XFASM12_RS07290	1626350..1627126	+	777	WP_027700469.1	polysaccharide deacetylase family protein	-
XFASM12_RS07300	1627770..1627961	-	192	WP_021358405.1	hypothetical protein	-
XFASM12_RS07305	1628379..1628798	-	420	WP_004085763.1	putative toxin-antitoxin system toxin component, PIN family	-
XFASM12_RS07310	1628798..1629037	-	240	WP_004085761.1	ribbon-helix-helix domain-containing protein	-
XFASM12_RS07315	1629482..1629724	+	243	WP_004085758.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
XFASM12_RS07320	1629717..1630004	+	288	WP_004085905.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
XFASM12_RS07325	1630092..1630658	+	567	WP_004085755.1	recombinase family protein	-
XFASM12_RS07330	1630711..1631907	-	1197	WP_012337730.1	transposase	-
XFASM12_RS07335	1631901..1632527	-	627	WP_038230952.1	IS607 family transposase	-
XFASM12_RS07340	1632757..1634031	-	1275	WP_012337985.1	pyridoxal phosphate-dependent aminotransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1627976..1649273	21297
	-	flank	IS/Tn	-	-	1630092..1630658	566

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-90)

Antitoxin

• Antitoxin ParD (1-78)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11159.64 Da
• Isoelectric Point: 5.9570

>T22757 WP_004085905.1 NC_010513:1629717-1630004 [Xylella fastidiosa M12]
MAKSYRLTPLAEADLEEIWFYTFRHWSIEQADSYHRSLVAVFEGLAAGTKQGCPSVLPDFNKYLCGSHVVYFMDYADHLD
IIRILHQRQDTERYL

Nucleotide

• Length: 288 bp

>T22757 NC_010513:1629717-1630004 [Xylella fastidiosa M12]
ATGGCTAAGTCCTATCGACTGACACCGCTGGCCGAGGCCGATCTTGAAGAAATCTGGTTCTACACATTCAGGCACTGGTC
GATAGAGCAGGCCGACAGCTACCACCGCAGCCTAGTTGCAGTTTTCGAGGGGCTGGCAGCAGGTACAAAGCAAGGCTGCC
CTTCTGTTTTGCCGGACTTCAATAAATACCTATGTGGTTCGCATGTAGTGTATTTCATGGATTACGCCGATCACTTGGAT
ATTATCCGCATCCTGCATCAGCGGCAGGATACCGAGCGGTACCTATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8774.77 Da
• Isoelectric Point: 6.9881

>AT22757 WP_004085758.1 NC_010513:1629482-1629724 [Xylella fastidiosa M12]
MSRNTSVALGPHFTSFIDAQVQGGRYGTASDVVRAGLRLLEEHETKVKALQDALNVGHQSGEPRPFDSEVFLSRMHTQHG

Nucleotide

• Length: 243 bp

>AT22757 NC_010513:1629482-1629724 [Xylella fastidiosa M12]
ATGAGTCGAAACACATCCGTTGCCCTCGGGCCGCACTTCACCAGCTTTATTGATGCCCAAGTCCAGGGCGGTCGCTACGG
TACCGCCAGCGATGTTGTCAGGGCCGGTCTGCGGCTACTTGAGGAACACGAAACAAAGGTGAAGGCACTGCAAGATGCGC
TGAATGTTGGCCACCAATCCGGCGAGCCGCGCCCGTTCGACAGCGAGGTGTTTTTGAGCCGGATGCACACGCAGCATGGC
TAA

Structures

Antitoxin

• AlphaFold DB: A0A060HDF9