Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 27335..28556 Replicon chromosome
Accession NZ_CP089061
Organism Pseudomonas aeruginosa strain UNC_PaerCF41

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag LSP19_RS00140 Protein ID WP_012614272.1
Coordinates 27978..28556 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag LSP19_RS00135 Protein ID WP_019396179.1
Coordinates 27335..27889 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSP19_RS00110 (LSP19_00110) 22903..23454 + 552 WP_016253541.1 helix-turn-helix domain-containing protein -
LSP19_RS00115 (LSP19_00115) 23451..23849 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
LSP19_RS00120 (LSP19_00120) 23862..24185 - 324 WP_003102734.1 multidrug efflux SMR transporter -
LSP19_RS00125 (LSP19_00125) 24516..24977 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
LSP19_RS00130 (LSP19_00130) 24982..27177 + 2196 WP_014603034.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
LSP19_RS00135 (LSP19_00135) 27335..27889 + 555 WP_019396179.1 helix-turn-helix transcriptional regulator Antitoxin
LSP19_RS00140 (LSP19_00140) 27978..28556 + 579 WP_012614272.1 HD domain-containing protein Toxin
LSP19_RS00145 (LSP19_00145) 28665..29852 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
LSP19_RS00150 (LSP19_00150) 29842..32013 - 2172 WP_009876279.1 type I secretion system permease/ATPase -
LSP19_RS00155 (LSP19_00155) 32003..33280 - 1278 WP_003122808.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21899.72 Da        Isoelectric Point: 5.3655

>T227568 WP_012614272.1 NZ_CP089061:27978-28556 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLASLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

>T227568 NZ_CP122956:587752-588018 [Helicobacter pylori]
GTGTTGAAACTCAACCTTAAAAAATCTTTCCAAAAAGATTTTGATAAATTACTTTTGAATGGGTTTGATGATAGCGTTTT
GAATGAAGTCATTCTAACCTTAAGAAAAAAAGAACCATTAGACCCACAATTTCAAGATCATGCTTTAAAGGGAAAGTGGA
AACCTTTTAGGGAATGCCACATCAAAGCTGATATTTTGCTTGTGTATCTAGTGAAAGATGATGAGCTTGTTTTGTTAAGA
CTAGGCAGTCATAGCGAGCTGTTTTAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20482.68 Da        Isoelectric Point: 8.1590

>AT227568 WP_019396179.1 NZ_CP089061:27335-27889 [Pseudomonas aeruginosa]
MTEPIPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPVRAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT227568 NZ_CP122956:587394-587771 [Helicobacter pylori]
ATGCCTAATTCTCCTACCAAAAAAGACTACACACAATACAGCGAAAAACAGCTTTTTAACTTAATCAATCAATTAGAGCA
AAAGATCAAAAAGATGCAAAATGATAGAGCTTCTTTTAAAGAAAAAATGGCTAAAGAATTGGAAAAAAGGGATCAAAACT
TTAAGGATAAAATAGACGCATTAAATGAACTCTTGCAAAAAATCAGCCAAGCTTTTGATGATAAAAGAGATTGTTGTTTG
GGGCGCAAGATCCCAAACCTTGAAACGCAACAAGCCATGAGAGATGCGCTCAACAAAGAGACAGATTTGATTGTTGAGGA
TTTTTCTAGTTACAGCGATGAAAGAAAAAGGGCTTTGGGTGTTGAAACTCAACCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References