Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YoeB-RelB
Location 30731..31241 Replicon plasmid pRIVM_C010761_4
Accession NZ_CP089048
Organism Acinetobacter ursingii strain RIVM_C010761

Toxin (Protein)


Gene name relE Uniprot ID A0A3D2SPX3
Locus tag LSO58_RS18950 Protein ID WP_034617162.1
Coordinates 30731..30991 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3D2SPQ8
Locus tag LSO58_RS18955 Protein ID WP_034617158.1
Coordinates 30975..31241 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LSO58_RS18935 (LSO58_18900) 28224..29156 + 933 Protein_31 IS5 family transposase -
LSO58_RS18940 (LSO58_18905) 29319..30070 - 752 Protein_32 IS5 family transposase -
LSO58_RS18945 (LSO58_18910) 30282..30689 + 408 WP_034617165.1 hypothetical protein -
LSO58_RS18950 (LSO58_18915) 30731..30991 - 261 WP_034617162.1 Txe/YoeB family addiction module toxin Toxin
LSO58_RS18955 (LSO58_18920) 30975..31241 - 267 WP_034617158.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LSO58_RS18960 (LSO58_18925) 31543..31776 + 234 WP_227567096.1 hypothetical protein -
LSO58_RS18965 (LSO58_18930) 32142..32915 - 774 WP_001053379.1 IS21-like element ISAba8 family helper ATPase IstB -
LSO58_RS18970 (LSO58_18935) 32915..33934 - 1020 WP_034617155.1 IS21-like element ISAba8 family transposase -
LSO58_RS18975 (LSO58_18940) 34209..34367 - 159 WP_155768699.1 hypothetical protein -
LSO58_RS18980 (LSO58_18945) 34638..34880 - 243 WP_224469590.1 hypothetical protein -
LSO58_RS18985 (LSO58_18950) 35150..35425 + 276 WP_034617152.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
LSO58_RS18990 (LSO58_18955) 35388..35654 + 267 WP_034617149.1 type II toxin-antitoxin system RelE/ParE family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..90792 90792
- inside IScluster/Tn - - 24877..45441 20564


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10422.89 Da        Isoelectric Point: 8.4866

>T227560 WP_034617162.1 NZ_CP089048:c30991-30731 [Acinetobacter ursingii]
MNRTIEFTDNAWDDYIYWQTQDKKVLKRINALIKECLRTPFEGTGKPEPLKANLSGFWSRRIDEKHRLVYEVTDERISIV
QCRFHY

Download         Length: 261 bp

>T227560 NZ_CP122948:1197433-1197744 [Helicobacter pylori]
ATGCTGAAAATTAGGCATCATATCTTTTTTAAAAAAGATTTTAAAAAACTTGTTAAAAACGGGTTTGATGATAGCGTTTT
GAAAGAAGTTATTCTAACCTTGAGAAAGAAAGAACCGCTACCCCCACAATTCAAAGATTACGCTTTAAAGGGAGTTTGGA
AGCCTTATAGAGAATGCCATATCAAAGCTGATGTTTTGCTTGTGTATTTAGTGAAAGATAATGAGCTTATTTTGTTAAGG
TTAGGCAGTCATAGCGAGTTGTTTTATAAACTACCCATAACGCTTAAAAAAAACGCAACAATCGCATGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9900.96 Da        Isoelectric Point: 4.3516

>AT227560 WP_034617158.1 NZ_CP089048:c31241-30975 [Acinetobacter ursingii]
MQVFTYTDARNNLKSVLDKVIDDADVAVITRKEGSHAVVMGQEHYDSLMETLYLLSSPNNAARLNESIAQLRASRTTERD
LIEDESDN

Download         Length: 267 bp

>AT227560 NZ_CP122948:1197087-1197446 [Helicobacter pylori]
ATGCCAAACACCACCAACAAAGATTACACAAAATACAGCCAAAGACAGCTTTTTAATCTCATGAATAAGAAAGAACAAGA
AATTGAAAAGCTAAAAAGAGATAGGGTATATCTTGAAAAGAAAATGGTTAAAGAGCTGGAAAAAAAAGATAAAGGTTTCA
CTATCAAGTTAGAAGAATTGAATAAGATCTTACAAGAGATCAACAAAAGAGCTAATGATTGTTGTTTTGGGCATGAGATC
CCAAACATTCAAACGCAACAAGCCATGAGAGAAGCGGATAATGGTGAAAACTTAGAAACTATTGAAGACTTTTCTGCATG
GGCAAATGAAATCAAAAAGGAAGTGAATGCTGAAAATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3D2SPX3

Antitoxin

Source ID Structure
AlphaFold DB A0A3D2SPQ8

References