Detailed information of TA system TA022756

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): FicTA/Fic(toxin)
• Location: 1238688..1239484
• Replicon: chromosome
• Accession: NC_010513
• Organism: Xylella fastidiosa M12

Toxin (Protein)

• Gene name: VbhT
• Uniprot ID: -
• Locus tag: XFASM12_RS05435
• Protein ID: WP_004087040.1
• Coordinates: 1238688..1239299 (-)
• Length: 204 a.a.

Antitoxin (Protein)

• Gene name: VbhA
• Uniprot ID: A0A060HF63
• Locus tag: XFASM12_RS05440
• Protein ID: WP_004087046.1
• Coordinates: 1239296..1239484 (-)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
XFASM12_RS05410	1235983..1236564	-	582	WP_012337852.1	Bro-N domain-containing protein	-
XFASM12_RS05415	1236824..1237207	-	384	WP_012337854.1	hypothetical protein	-
XFASM12_RS05420	1237295..1237624	-	330	WP_021358651.1	hypothetical protein	-
XFASM12_RS05425	1237614..1237859	-	246	WP_012337855.1	hypothetical protein	-
XFASM12_RS05430	1237858..1238637	+	780	WP_021358652.1	helix-turn-helix transcriptional regulator	-
XFASM12_RS05435	1238688..1239299	-	612	WP_004087040.1	Fic/DOC family protein	Toxin
XFASM12_RS05440	1239296..1239484	-	189	WP_004087046.1	antitoxin VbhA family protein	Antitoxin
XFASM12_RS05445	1239865..1240269	+	405	WP_012337857.1	hypothetical protein	-
XFASM12_RS05450	1240266..1240727	+	462	WP_012337858.1	DUF1566 domain-containing protein	-
XFASM12_RS05455	1240724..1241131	+	408	WP_012337859.1	hypothetical protein	-
XFASM12_RS05460	1241128..1241319	+	192	WP_004086069.1	hypothetical protein	-
XFASM12_RS05465	1241351..1241920	-	570	WP_012337860.1	DEAD/DEAH box helicase	-
XFASM12_RS05470	1242005..1242409	+	405	WP_004085029.1	hypothetical protein	-
XFASM12_RS05475	1242411..1242689	-	279	WP_012337663.1	VRR-NUC domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1210795..1261740	50945

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (55-152)

Antitoxin

• Antitoxin VbhA (10-56)

Sequences

Toxin

Protein

• Length: 204 a.a.
• Molecular weight: 22961.76 Da
• Isoelectric Point: 5.1271

>T22756 WP_004087040.1 NC_010513:c1239299-1238688 [Xylella fastidiosa M12]
MKYAGDRGDPYLDSETGVLRNLLGIRDQGWLDKIESTLSFLRTSELRERPVKGKFDLAHLQEIHNRLFQDVYDWAGQIRQ
VEISKGNTMFAQQIAIQSAAQQIFGQLAKERFLCGLDAEEFSKRAGDYLGEINVLHPFREGNGRTQREFIAQLAQRAGYR
IDWGVVSQADMIKASIDAYNGDSSGLASIIREGISDQLFKDNE

Nucleotide

• Length: 612 bp

>T22756 NC_010513:c1239299-1238688 [Xylella fastidiosa M12]
ATGAAATACGCAGGGGATCGTGGTGATCCTTACCTGGACAGCGAAACAGGTGTTCTTCGTAATCTCCTTGGAATCAGGGA
TCAGGGGTGGCTCGATAAAATAGAGTCCACCCTTTCTTTTTTGCGAACCAGCGAATTGCGTGAGCGACCCGTAAAAGGCA
AATTTGATCTAGCGCATTTACAGGAAATCCATAATCGTCTTTTCCAGGATGTGTACGACTGGGCGGGTCAAATCCGTCAA
GTTGAAATCTCGAAAGGCAACACGATGTTTGCCCAGCAGATTGCGATTCAGAGTGCGGCGCAGCAGATCTTTGGGCAGCT
TGCTAAAGAGCGATTTTTGTGTGGCCTTGATGCTGAAGAATTCAGCAAACGGGCAGGTGATTATCTTGGTGAAATTAATG
TGCTCCACCCATTCCGCGAGGGAAATGGCAGGACGCAACGGGAATTCATTGCGCAATTGGCTCAGCGTGCAGGTTACCGG
ATCGACTGGGGCGTGGTCAGCCAGGCGGATATGATTAAAGCGTCAATCGACGCTTACAACGGGGATTCAAGTGGATTGGC
TAGTATCATCCGCGAAGGAATATCTGATCAGCTTTTTAAAGATAATGAGTAA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 6855.80 Da
• Isoelectric Point: 4.9859

>AT22756 WP_004087046.1 NC_010513:c1239484-1239296 [Xylella fastidiosa M12]
MLTDHEKAERRAVVQSALASQRIEGLEPDAQAVVDAECWARGEMTIAAAVDQYKARVRLQMA

Nucleotide

• Length: 189 bp

>AT22756 NC_010513:c1239484-1239296 [Xylella fastidiosa M12]
ATGCTGACAGATCATGAGAAAGCTGAACGCCGTGCTGTGGTGCAAAGCGCACTCGCAAGCCAACGCATTGAGGGGTTAGA
GCCGGATGCGCAAGCCGTTGTTGATGCTGAATGCTGGGCGCGTGGTGAAATGACTATCGCTGCCGCCGTGGACCAGTACA
AAGCGCGTGTTCGGCTCCAGATGGCATGA

Structures

Antitoxin

• AlphaFold DB: A0A060HF63